Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"retinal vasculature"”.
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Morphometric measurements of the retinal vasculature in ultra-wide scanning laser ophthalmoscopy as biomarkers for cardiovascular disease
Retinal imaging enables the visualization of a portion of the human microvasculature in-vivo and non-invasively. The scanning laser ophthalmoscope (SLO), provides images characterized by an ultra-wide field of view (UWFoV) covering approximately 180-200º in a single scan, minimizing the discomfort …
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The traditionally protective cystathionine gamma-lyase/hydrogen sulfide pathway contributes to pathological retinal neovascularization in oxygen-induced retinopathy
… beneficial in ischemic tissue. However, retinal ischemia can cause pathological vessel growth which disrupts the precise ocular architecture and leads to irreversible vision loss. Our goal was to determine the role of the CSE/H2S pathway in ischemia-induced pathological retinal …
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High A-scan rate optical coherence tomography angiography for blood flow speed quantification in the retina
… non-invasive and depth-resolved imaging of the retinal vasculature. While OCTA is widely used to study retinal disease, it traditionally provides limited information about blood flow speed. This thesis introduces a second-generation variable interscan time analysis (VISTA) OCTA, designed to …
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Quantitative Analysis of Retinal Vascular Morphology and Dynamics Using Optical Coherence Tomography
… for noninvasive examination of the body’s microvasculature and may reveal early signs of systemic and retinal diseases. Optical coherence tomography (OCT) provides depth-resolved, high-resolution imaging, making it suitable for detailed analysis of retinal vasculature. However, challenges remain …
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Premature vascular senescence during diabetic retinopathy
… to investigate the senescence profile of human retinal microvascular endothelial cells (HRMECs), to elucidate how this is affected by the diabetic milieu. <br/><br/>HRMECs undergo replicative senescence in vitro and they acquire gene and protein expression profiles that are characteristic of a …
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The manual analysis of human biometric identifiers in non-pathological retinal fundus images: An evaluation of presented methodologies and a survey of identifiers within open source databases
From the initial proposal of the use of retinal fundus images to enable human identification in 1935, identity biometrics based upon digital representations of the retinal fundus have been proposed as a highly effective modality applied for high level security applications. As complex internal …
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MELANOPSIN AND PACAP IN INTRINSICALLY PHOTOSENSITIVE RETINAL GANGLION CELLS REGULATE THE DEVELOPMENT OF RETINOFUGAL PROJECTIONS IN MICE
In the retina, a small subset of retinal ganglion cells are intrinsically photo-sensitive (ipRGCs) and express the photopigment melanopsin and the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP). These cells project to brain nuclei to mediate a variety of visual behaviors …
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Vascular changes in Alzheimer’s disease and other types of dementia in the retina of human and animal
… explore if an association exists between Aβ and retinal vasculature. Aβ accumulations were identified in flat-mount retina and cross-sections from AD and age-matched control eyes. Aβ labelling was found in clusters associated with retinal blood vessels, in spherical structures within drusen, …
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Experimental porcine models of retinal ischemia
Retinal ischaemia resulting from e.g. diabetes, vein thrombosis or arterial occlusion, is one of the major causes of visual impairment and blindness. Although new methods of treatment are being developed, there is still a need for more effective pharmacological forms of treatment. The aim of this …
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Mechanistic and therapeutic evaluation of a novel antiantiogenic small molecule
… selective antiangiogenic activity against human retinal endothelial cells. Intravitreal SH- 11037 dose-dependently suppressed angiogenesis in the laser-induced CNV (LCNV) mouse model. These effects were prominent as early as 7 days post-laser treatment as measured by a novel ellipsoid …
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Investigating the integrity of the vasculature and structural relationships of pericytes, astrocytes and the endothelial glycocalyx in an ex vivo hyperglycaemic rat retinal model
… is characterised by the degeneration of the retinal microvascular and neural components that form the blood retinal barrier (BRB), and is due to diabetic metabolic derangements such as hyperglycaemia. The cellular components of the BRB include endothelial cells, pericytes and the glial cells …
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Single cell transcriptomics of the retinal vascular endothelium in health and diabetes
The endothelial cells that line retinal blood vessels play vital roles in angiogenesis and microvascular barrier formation and are supported by retinal mural cells. When these cells become dysfunctional during diabetes, they can lead to sight threatening complications such as diabetic retinopathy …
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Relationships between subtle ocular changes and microvascular complications in people with type 2 diabetes
… develop analytical methods of quantifying retinal and choroidal biomarkers of structure and/or function, including novel biomarkers such as choroid thickness, choriocapillaris perfusion, and retinal capillary perfusion, to ensure collection of high-quality data for aims 1) and 2). Methods: …
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An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model.
… endothelial cells (HDMEC) and porcine retinal vasculature is presented with three mechanistic pathways of transcriptional factors regulating the redox (nuclear factor type-2 (Nrf2)), pro-inflammation (Nuclear Factor kappa B; (NFᴋB)), and oxygen signalling (hypoxia inducible factor type …
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Characterisation of endothelial cell metabolic plasticity and vascular remodelling in the retina
… severe vision loss. A key component cell of the retinal neurovascular unit is the vascular endothelium, which is significantly impacted by the diabetic milieu. It has now been established that the endothelium relies on glycolytic metabolism predominantly for ATP generation, however the degree of …