Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"retinal pigment epithelium"”.
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Localization of Cytoskeletal Elements in Teleost Retinal Pigment Epithelium
The G.3.5 antigen (Mr = 100,000) has been localized in brain, cerebellum, skeletal, cardiac, and smooth muscle tissues using the G.3.5 mAb, and has been described as an IFAP on the basis of its co-localization and co-isolation with desmin. Through biochemical analysis, the G.3.5 antigen was found …
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Transthyretin expression in cultured and native human retinal pigment epithelium
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Induction of the retinal pigment epithelium of the chicken embryonic eye
… optic cup gives rise to a double layered neuroepithelium, part of which differentiates into the retinal pigment epithelium (RPE). The molecular mechanisms which control differentiation of the RPE are not known. The present study was undertaken to determine 1) when induction of the RPE has …
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The Impact of Iron on Lysosomal Function in the Retinal Pigment Epithelium
… transport in the retina and how iron can cause retinal damage are fully understood. In this work, we first refine the understanding of iron transport in the retina by examining hephaestin, a ferroxidase, and demonstrating that it has a local role in regulating iron homeostasis in the neural …
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Monitoring intracellular cavitation during selective laser targeting of the retinal pigment epithelium
Thesis (Mech. E.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2002.
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Bioinformatic and molecular approaches for the analysis of the retinal pigment epithelium (RPE) transcriptome
… pathogenesis likely involves processes in the retinal pigment epithelium (RPE) (Liang and Godley, 2003). The goal of the current study was to identify and characterize genes specifically or abundantly expressed in the RPE in order to determine more comprehensively the transcriptome of the RPE. …
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
… extracellular deposits, termed drusen, below the retinal pigment epithelial (RPE) cell layer in the outer retina is a pathognomonic hallmark of AMD. The composition of drusen is complex, but identified elements include iron, complement components, and amyloid protein derivatives. This suggests …
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Systematic analysis of genes expressed in the retinal pigment epithelium (RPE) and identification of candidates for genetic susceptibility to age-related macular degeneration (AMD)
… in recent years a primary involvement of the retinal pigment epithelium (RPE) has become evident. The aim of the present study is to systematically analyse genes which are differentially expressed in the RPE, and to assess their possible association with mechanisms and pathways likely to be …
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Carbachol-Induced Pigment Granule Dispersion
The retinal pigment epithelium (RPE) is a monolayer of pigmented, simple cuboidal epithelium with long apical processes that interdigitate with photoreceptors. In teleosts, the RPE aids in light adaptation through pigment granule movements. In the bright light, pigment granules are dispersed into …
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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
… species (ROS) and pro-inflammatory cytokines in retinal pigment epithelium cells. The primary purpose of this study was the development of a clear, tacrolimus nanomicellar formulation (TAC-NMF) for AMD. The optimized formulation had a mean diameter of 15.41 nm, zeta potential of 0.5 mV and an …
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The maculoprotective effect of a thiol antioxidant in retinal degeneration models
… amide (NACA), a thiol antioxidant, would protect retinal pigment epithelium and impede the progression of retinal degeneration. The goal of this work was to evaluate the efficacy of NACA in preventing retinal pigment epithelial cell and photoreceptor death in AMD models. To achieve this, we used …
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Cellular uptake and actions of bilberry anthocyanins in retinal pigment epithelial cells
… age-related macular degeneration (AMD). In AMD, retinal pigment epithelium (RPE) cells are damaged by oxidative stress and die via the process of apoptosis. Anthocyanins from fruits and berries, such as bilberry (Vaccinium myrtillus), possess significant antioxidant activity in vitro and have …
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Regulating the bioactivity of placental growth factor in the aging outer retina as a new therapeutic approach to age-related macular degeneration
… However, it has been shown to propagate retinal pathology in animal models. Reports also suggest that PlGF can induce epithelial cell dysfunction and its inhibition has shown efficacy in a mouse model of GA. In this thesis, it was hypothesised that PlGF can induce dysfunction of retinal …
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Mutation analysis of important retinal candidate genes: progression from research to diagnostic service
… inherited disease includes defects of the eye. Retinal degenerative disorders (RDDs) are a group of diseases characterised by photoreceptor cell death in the retina and consequent vision loss. The Division of Human Genetics at the University of Cape Town (UCT) has samples archived in the RDD DNA …
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Deciphering Underlying Mechanisms Of Photoreceptor Outer Segment Degradation; Involvement Of Intracellular Trafficking
… by the degeneration of photoreceptors and retinal pigment epithelium (RPE) cells in the macula region of the retina. RPE maintain the health of the retina by providing support to the photoreceptor cells and the retina through various tasks. One major task RPE cells are involved in, is daily …
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Modulation of cell morphology and function using synthetic biodegradable polymers
… and tissue formation using cells derived from retinal pigment epithelium (RPE) as an in vitro model. RPE cells were shown to attach to and proliferate on PLGA films during a 7-day culture period. Both polymer composition and initial cell seeding density affected cell growth. PLGA films were …
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Microscale Tissue Engineering and Contributors of the Cellular Niche
… approaches were specifically validated in the retinal and islet systems, they were also designed to be easily implemented in other biological systems. One project showcases a novel scaffold-free, scalable and injectable retinal pigment epithelium (RPE) microtissue for minimally-invasive …
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Clinical and Experimental Approach to the Benefits and Risks of Laser Treatment for Diabetic Macular Edema
… the long-term effects of laser treatment, the retinal sensitivity in 29 consecutively recruited subjects with diabetic macular edema was assessed by visual fields before and after laser treatment every 6 months during a period of 2 years (Study II). To investigate the cellular and molecular …
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Understanding the genetics and function of complex human retinal phenotypes
… of the retina from which measures describing retinal morphology can be extracted. This thesis summarises my research into the genetic variation underlying retinal morphology. Firstly, I explored the morphology of the inner retina, whose thickness is used as a biomarker of glaucoma, using …
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