Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"retinal pigment epithelial cell"”.
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Identification of novel synthetic lethal interactions using multiplexed CRISPR-Cas9 screening
… loss of either of the pair is compatible with cellular viability, but simultaneous loss of both genes induces cell death. This approach can therefore exploit somatically acquired mutations to specifically kill tumour cells and to define new therapeutic targets. Abstract In order to do this, we …
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The maculoprotective effect of a thiol antioxidant in retinal degeneration models
… amide (NACA), a thiol antioxidant, would protect retinal pigment epithelium and impede the progression of retinal degeneration. The goal of this work was to evaluate the efficacy of NACA in preventing retinal pigment epithelial cell and photoreceptor death in AMD models. To achieve this, we used …
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Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
… expression of KDMs in a number of cancer and retinal pigment epithelial cell lines. The results provide an evidence-based scientific explanation for therapeutic benefits observed with honokiol and berberine. On comparing the anti-HIF effect of both these compounds honokiol was found to possess …
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Vascular breakdown in diabetic retinopathy: Role of connexin43 and possible interventions
… shown to contribute to geographic atrophy and retinal ganglion cell death. Therefore, alternative treatments that target upstream disease mechanisms are needed. Recent studies have shown that connexin43 hemichannels play a role in the pathogenesis of chronic inflammatory diseases and blocking …
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Mechanism of Action of Nicotinamide Phosphoribosyltransferase Mediated Signaling in Oxidative Stress
… stress. Neuroprotection and protection of cells supporting the function of neurons could provide novel therapeutic approaches to treating and preventing neurodegenerative diseases when therapies do not exist or existing therapies fail (3). Nicotinamide phosphoribosyltransferase (Nampt) is …