Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"retinal pigment epithelial (RPE) cells"”.
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Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders
… (TGF-β) plays a key role in transforming retinal pigment epithelial (RPE) cells into mesenchymal fibroblastic cells, which are implicated in fibrotic disorders of the retina. Herein, the effect of pirfenidone, a novel anti-fibrotic agent, on TGF-β1-mediated fibrogenesis in the human RPE …
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The Transformation of Human Retinal Pigment Epithelial Cells
… disease and the most common cause of fail ure of retinal reattachment surgery. Although the etiology of this disease is unknown, TGFβ has been implicated as a key factor contributing to PVR.</p> <p>The risk factors of PVR include a tear on the neural retina, breakdown of blood-retinal barrier, and …
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Reactive Oxygen Species (ROS) Triggered Delivery System for the Treatment of Diabetic Retinopathy
… growth factor (VEGF) and proliferation of basal epithelial cells. Celecoxib is reported to be useful in the treatment of DR due to its anti-VEGF activity and anti-proliferative effects on the retinal pigment epithelial (RPE) cells. Another drug memantine is reported to prevent the …
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Transcriptional and structural control of cell identity genes
… in DNA are selectively interpreted by cells to specify various cellular functions is a fundamental question in biology. This thesis work describes two genome-wide studies designed to study how transcriptional control of gene expression programs defines cell identity. Recent studies …
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Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases
… in cancer chemotherapy. Human adenocarcinoma cells (LS-180) were treated for 72 hours with vinblastine alone and in the presence of ritonavir. The expression of efflux transporters (MDR1 and MRP2), metabolizing enzyme (CYP3A4) and nuclear hormone receptor (PXR) was induced in response to …
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The cloning and characterisation of the chicken tyrosinase-related protein gene family
… the molecular and genetic mechanisms controlling pigmentation within the bird kingdom. The aim therefore, of this study was to contribute towards the understanding of the genetic regulation of avian pigmentation by the cloning and characterisation of the chicken Tyrosinase-related protein (TRP) …
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Biochemical Investigations of Macular Degeneration: The Significance of Protein Oxidation including Novel Methods for Its Study
<p>The retinal pigment epithelium (RPE) is a monolayer of cells located directly behind the photoreceptor cells in the retina. These cells are involved in a variety of functions that support the visual process in the eye, namely 1) they form a blood-retina barrier which separates the neural retina …
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Cell type-specific regulation of the chicken tyrosinase promoter
Melanin, the pigment found in the eyes and coats of vertebrates, is synthesised by two main cell types: melanocytes and retinal pigment epithelial (RPE) cells. These two cell populations. which arise from distinct embryological origins, differ with respect to the rate at which they produce melanin …
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Investigating Cellular and Molecular Mechanisms of Neuronal Layering in Self-Organising Aggregates of Zebrafish Retinal Cells
… neuronal types organised into distinct layers: Retinal Ganglion Cell (RGC), Amacrine Cell (AC), Bipolar Cell (BP), Horizontal Cell (HC) and Photoreceptor cell (PR) layers. This remarkable organisation is evolutionarily conserved in vertebrates, yet little is known about the mechanisms by which …