Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"retinal microvascular"”.
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Investigating Notch/Dll4 signalling in retinal microvascular cells in health and disease
… Dll4 on Notch1 activation in mature primary retinal microvascular endothelial cells (RMECs). We demonstrated using lentiviral-mediated shRNA knockdown that Dll4 has important roles in mediating cell-cell junction and that removal of Dll4 induces an enlarged senescent-like phenotype. These …
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RENAL AND RETINAL MICROVASCULAR RELATIONSHIPS AND INCIDENT CHRONIC KIDNEY DISEASE: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS
… the potential to alter clinical practice. The microvascular bed may
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The retinal microvasculature as an early indicator of chronic disease risk in older populations
… been suggested that the measurement of retinal blood vessel parameters could provide an increased understanding of chronic systemic diseases with a vascular component. This easy, non-invasive imaging modality provides an indication of microvascular health that may reflect ongoing changes …
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Investigation of novel biomarkers associated with renal disease
… a body of work examining associations between retinal biomarkers (retinal microvascular parameters [RVP] and retinal layer thickness measurements) and measures of renal function and damage (estimated glomerular filtration rate and urinary albumin to creatinine ratio). Retinal biomarkers have …
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Chemomechanical regulation of integrin activation and cellular processes in acidic extracellular pH
… behavior of [alpha]v[beta]3 CHO-B2 cells, bovine retinal microvascular endothelial cells, and NIH-3T3 fibroblasts in an extracellular pH gradient is investigated. Results demonstrate that NIH-3T3 fibroblasts do not exhibit directional preferences in the pHe gradient, but that [alpha]v[beta]3 …
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Premature vascular senescence during diabetic retinopathy
… to investigate the senescence profile of human retinal microvascular endothelial cells (HRMECs), to elucidate how this is affected by the diabetic milieu. <br/><br/>HRMECs undergo replicative senescence in vitro and they acquire gene and protein expression profiles that are characteristic of a …
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Characterisation of endothelial cell metabolic plasticity and vascular remodelling in the retina
… (DR) is the most frequently occurring microvascular complication of diabetes mellitus, where the later stages of the disease are often is chaemia driven which can result in severe vision loss. A key component cell of the retinal neurovascular unit is the vascular endothelium, which is …
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Benefits and accessibility of OCTA imaging for diabetic retinopathy and macular edema
… advantages to the current standard for assessing retinal microvascular changes in diabetic eye diseases. This study aims to evaluate the cost-effectiveness of different screening strategies incorporating OCTA for the detection and management of DR and DME. A decision tree model (Figure 2) was …
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Role of pericytes in the barrier task
… and controlling tissue homeostasis. The blood-retinal barrier (BRB) is a blood-ocular barrier system, made up of an inner and an outer barrier. BRB is located in the retinal microvasculature and include the microvascular endothelium. The role of the BRB is to control molecule trafficking: ion, …
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Diabetic macular oedema: the role of steroids and VEGF
… Initial pilot studies suggest it can decrease retinal thickening and increase visual acuity in the long-term. Vascular endothelial growth factor is thought to play a critical role during the pathogenesis of diabetic macular oedema. The mechanism of action of both steroids and vascular …
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Investigating the integrity of the vasculature and structural relationships of pericytes, astrocytes and the endothelial glycocalyx in an ex vivo hyperglycaemic rat retinal model
… is characterised by the degeneration of the retinal microvascular and neural components that form the blood retinal barrier (BRB), and is due to diabetic metabolic derangements such as hyperglycaemia. The cellular components of the BRB include endothelial cells, pericytes and the glial cells …
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Investigation of the role of Glil+ cells in retinal angiogenesis and fibrosis.
… lesion development. Cell survival assays of retinal pigment epithelial and microvascular endothelial cells in the presence of TGFβ2 together with/without Gli1 inhibitor GANT61 were utilised to interrogate the role of Gli1 in mesenchymal transition.<br/><br/>Results: Expression of Gli1-Tomato …