Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"retinal layers"”.
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Graph Theory and Dynamic Programming Framework for Automated Segmentation of Ophthalmic Imaging Biomarkers
… as an accurate technique for segmenting retinal layers on OCT images. The framework was then extended through the development of the quasi-polar transform to segment closed-contour structures including photoreceptors on AO scanning laser ophthalmoscopy images and retinal pigment …
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Understanding the genetics and function of complex human retinal phenotypes
… of the retina from which measures describing retinal morphology can be extracted. This thesis summarises my research into the genetic variation underlying retinal morphology. Firstly, I explored the morphology of the inner retina, whose thickness is used as a biomarker of glaucoma, using …
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X-LINKED RETINOSCHISIS ELECTROPHYSIOLOGY, MOLECULAR GENETICS AND TREATMENT
… (XLRS) is a congenital progressive inherited retinal disease that affects the entire retina and is one of the more common causes of vision loss from retinal degeneration affecting young men,. The progression is variable but seems to be relatively stationary in the ages 6 to 25 years. Patients …
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Relationships between subtle ocular changes and microvascular complications in people with type 2 diabetes
… develop analytical methods of quantifying retinal and choroidal biomarkers of structure and/or function, including novel biomarkers such as choroid thickness, choriocapillaris perfusion, and retinal capillary perfusion, to ensure collection of high-quality data for aims 1) and 2). Methods: …
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Investigation of novel biomarkers associated with renal disease
… a body of work examining associations between retinal biomarkers (retinal microvascular parameters [RVP] and retinal layer thickness measurements) and measures of renal function and damage (estimated glomerular filtration rate and urinary albumin to creatinine ratio). Retinal biomarkers have …
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Advanced functional and intraoperative ophthalmic optical coherence tomography imaging
… visualization of thickness changes in the outer retinal layers after flash stimulus and subsequent dark adaptation. This finding could be used as a marker for photoreceptor health in retinal diseases that influence dark adaptation such as age-related macular degeneration. In the operating room, …
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The Effect of Gonadotropin Releasing Hormone on Opsin Gene Expression and Spectral Sensitivity in Zebra Cichlid Fish (Metriaclima zebra).
… fibers and GnRH receptors throughout the retinal layers make it an excellent candidate for mediating changes in visual processes. Effects of exogenous GnRH administration on the visual system of zebra cichlids (Metriaclima zebra) via prolonged release cholesterol implants and intubation …
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Neuroprotective effects of PACAP, VIP and NAP against hyperglycaemic retinal damage
… process characterizes DR. The reason for the retinal degeneration resides in the metabolic changes caused by hyperglycemia and in the decreased capability of the retina to adapt to this environment. This situation leads to altered expression patterns of neuropeptides, growth and transcription …
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Optical coherence tomography: evaluation and clinical application
… outcomes. Direct cross-sectional imaging of retinal structure could be useful for early diagnosis and more sensitive monitoring of a variety of retinal conditions such as macular oedema and glaucoma. The view of the fundus given by ophthalmoscopy provides very limited depth information and …
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The role of Interleukin-33 in retinal degenerative diseases
… and they play an essential role in maintaining retinal homeostasis by supporting neuronal and vascular function. In disease settings, dysregulation of Müller cells leading to their prolonged activation is known to be critical for neurovascular pathology, especially in degenerative conditions …
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An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model.
… endothelial cells (HDMEC) and porcine retinal vasculature is presented with three mechanistic pathways of transcriptional factors regulating the redox (nuclear factor type-2 (Nrf2)), pro-inflammation (Nuclear Factor kappa B; (NFᴋB)), and oxygen signalling (hypoxia inducible factor type …