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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"retinal ganglion cells"”.
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Functional Dynamics of Primate Retinal Ganglion Cells
… and temporal contrast signals. The responses of retinal ganglion cells to such signals provide the means to explore such processing in the retina. Most primate retinal ganglion cells fall into two broad classes, M and P, which have many anatomical and physiological differences. The responses of M …
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Extracellular electrical stimulation of retinal ganglion cells
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1994.
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Fast reconstruction of motion from multielectrode records of retinal ganglion cells
… ist in den Aktionspotentialfolgen (Spike Trains) retinaler Ganglienzellpopulationen repräsentiert und wird über den optischen Nerv an das Gehirn übertragen. Die hohe Geschwindigkeit dieses Prozesses spiegelt die Herausforderung durch die Natur wider, welcher das visuelle System durch schnelle und …
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Motion Processing in Direction Selective Retinal Ganglion Cells through Dynamic Environments
<p>Direction selective ganglion cells (DSGCs) signal the presence and direction of motion from the retina to multiple brain areas. Reliably signaling motion is critical through dynamic environments, including contrasts and light levels. This dissertation examines how direction-selective responses …
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Deciphering the neural code for retinal ganglion cells through statistical inference
… encodes information in the firing patterns of retinal ganglion cells. We present a visual scene to a retina, obtain in-vitro recordings from a multi-electrode array, and attempt to identify or reconstruct the scene. Our approach uses the well-known linear-nonlinear Poisson model to characterize …
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Neuronal Diversification Within the Retina: Generation of Crossed and Uncrossed Retinal Ganglion Cells
… and their corresponding axon projections. Retinal axon divergence at the optic chiasm midline is key to the establishment of binocular vision in higher vertebrates. In the visual system of binocular animals, the ipsilaterally and contralaterally projecting retinal ganglion cells are …
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Computational Modelling of Functionally-Identified Retinal Ganglion Cells using a Multi-Objective Optimisation Approach
Retinal neuroprostheses aim to restore functional visual percepts to patients suffering from retinal degenerative diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD). In such patients, it is desirable to reconstruct a useful sense of artificial vision by …
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An Analysis of Spatial Summation in the Receptive Fields of Goldfish Retinal Ganglion Cells
<p>The axons of retinal ganglion cells convey the signals from which the brain constructs its visual percept of the world. The considerable processing done in the retina is implicit in these signals; it is therefore desirable to understand this processing in some detail. Only one aspect of retinal …
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The Maturation of Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells and Their Degeneration in Glaucoma
… brain is severed leading to the degeneration of retinal ganglion cells (RGCs) and eventual blindness. A need exists to better understand the maturation of human RGCs as well as their degeneration, with the goal of developing new therapeutics diseases like glaucoma. Human pluripotent stem cells …
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MELANOPSIN AND PACAP IN INTRINSICALLY PHOTOSENSITIVE RETINAL GANGLION CELLS REGULATE THE DEVELOPMENT OF RETINOFUGAL PROJECTIONS IN MICE
In the retina, a small subset of retinal ganglion cells are intrinsically photo-sensitive (ipRGCs) and express the photopigment melanopsin and the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP). These cells project to brain nuclei to mediate a variety of visual behaviors …
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Growth Differentiation Factor 11 Promotes Survival of Mouse Retinal Ganglion Cells in Vitro through Smad2/3 Activation
… developing retina, and GDF11 protein can signal retinal ganglion cells (RGCs) to grow dendrites in vitro. The developmental expression pattern of GDF11 in RGCs and the impact of GDF11 on mammalian RGCs remain unknown. The current study investigated 1) the developmental time course of GDF11 …
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Systemic AAV-Mediated Gene Therapy Using Epo-R76E to Protect Retinal Ganglion Cells from Optic Nerve Injury and Disease
… glaucoma.</p> <p>Optic nerve crush is a model of retinal ganglion cell (RGC) death. Crushing the optic nerve causes the axons to undergo Wallerian degeneration and apoptotic loss of retinal ganglion cells over time. This pattern of cell death is very similar to that observed in glaucoma. The …
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Retinal ensemble coding under dynamic conditions
Spike trains of retinal ganglion cells transfer visual information from the eye to the brain. Since natural scenes comprise several visual features, this study investigates how the activity of retinal ganglion cells encodes motion information under dynamic light intensity conditions. Multiple …
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From statistical mechanics to machine learning: effective models for neural activity
In the retina, the activity of ganglion cells, which feed information through the optic nerve to the rest of the brain, is all that our brain will ever know about the visual world. The interactions between many neurons are essential to processing visual information and a growing body of evidence …
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Advanced technologies for spatio-temporal control of neural circuits using optogenetics
… the neural activity of genetically targeted cells with techniques known as optogenetic stimulation. The combination of optogenetic stimulation methods with electrophysiological recordings and advanced optical imaging is leading to promising approaches aiming at obtaining information on …
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Preformulation Characterization And Formulation Development of Δ9-Tetrahydrocannabinol Prodrugs For Potential Treatment Of Glacuoma
… agents that can lower IOP as well as protect the retinal ganglion cells from apoptosis could yield a new class of anti-glaucoma molecules. Protection of retinal ganglion cells against apoptosis could yield a new class of antiglaucoma agents. Numerous investigations have demonstrated that THC also …
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Biomarkers of Optic Nerve Head Glial Cell Activation Following Biomechanical Insult
… by the slow and irreversible apoptotic death of retinal ganglion cells, a unique optic nerve neuropathy resulting in loss of vision. Increased intra-ocular pressure is known to be a leading risk-factor for glaucoma, and lowering IOP is currently the only evidence based method for the clinical …
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Expression of microbial rhodopsins in retinal neurons with subcellular targeting motifs: for the study of the structure/function of aii amacrine cells and for vision restoration
… to recreate center-surround antagonism in retinal ganglion cells (RGCs). Results of the study showed that a smaller center and a larger encompassing surround receptive field can be generated directly in a single RGC both morphologically and physiologically through the use of protein …
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Estimating light edge velocity based on retinal ganglion cell spike trains
… is moving on the photoreceptor layer of a rabbit retinal patch. We make these estimates based solely on the electrical response measured from the retinal ganglion cells (RGCs). We present various algorithms for doing so and present sensitivity analysis of such algorithms. We test the performance …
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