Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"retinal ganglion cell"”.
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MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
… “Modifying Chondroitin Sulfation Enhances Retinal Ganglion Cell Axon Regeneration,” I, Craig Pearson, seek to determine the time course and spatial distribution of CSPG accumulation in the glial scar following acute injury, and then to demonstrate that ARSB is effective in reducing the …
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Estimating light edge velocity based on retinal ganglion cell spike trains
… is moving on the photoreceptor layer of a rabbit retinal patch. We make these estimates based solely on the electrical response measured from the retinal ganglion cells (RGCs). We present various algorithms for doing so and present sensitivity analysis of such algorithms. We test the performance …
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Predicting Retinal Ganglion Cell Responses Based on Visual Features via Graph Filters
… approaches as well. We apply this model to a retinal coding problem where explainability is essential to gain conceptual insight about the retina.
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Development of Techniques for Analysis of the Human Retinal Ganglion Cell Transcriptome: Application to the Role of Calcium in RGC Death in Glaucoma
Purpose: Irreversible retinal ganglion cell (RGC) death is the reason for visual loss in glaucoma. However, the mechanisms of RGC death remain unclear. The aim of this research was to develop methods to study mRNA expression profiles in human RGCs, then to use the data to investigate the role of …
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Human Organotypic Retinal Cultures as a model of human retinal ganglion cell degeneration in glaucoma. Effects of epigenetic regulation and mesenchymal stem cell derived growth factors.
Purpose: Human Organotypic Retinal Cultures (HORCs) have been shown to be a useful experimental model to investigate retinal ganglion cell (RGC) fate in short term models of glaucomatous stress. The aim of the current work was to investigate the long-term fate of RGCs in HORCs and to develop …
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The mechanical regulation of Semaphorin3A signalling in the developing Xenopus laevis brain
… Specifically, I studied how the response of retinal ganglion cell axons to the classical repulsive chemical guidance cue Semaphorin3A is regulated by substrate stiffness. The strength of axonal turning responses to Semaphorin3A can be quantified using a turning assay, whereby axons change …
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Retinal ensemble coding under dynamic conditions
Spike trains of retinal ganglion cells transfer visual information from the eye to the brain. Since natural scenes comprise several visual features, this study investigates how the activity of retinal ganglion cells encodes motion information under dynamic light intensity conditions. Multiple …
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Axon guidance in the zebrafish visual system: Analysis of Esrom Mutant
… The gene function is required in the eye for retinal ganglion cell (RGC) targeting. Using positional cloning esrom was found to be an orthologue of PAM/Hiw/RPM-1. This large multidomain protein has an E3 ligase activity. Esrom is ubiquitously expressed in the embryo. RGCs require it for proper …
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The Intracellular Domain of EPHB1 Is Required for Axon Pathfinding at the Optic Chiasm and Corpus Callosum
… of the importance of EphB1 mediated signaling in retinal and callosal axons while attempting to reach their targets. EphB receptor tyrosine kinases direct axonal pathfinding through interactions with ephrin-B proteins following axon-cell contact. Since EphB:ephrin-B binding leads to bidirectional …
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Computational Modelling of Functionally-Identified Retinal Ganglion Cells using a Multi-Objective Optimisation Approach
Retinal neuroprostheses aim to restore functional visual percepts to patients suffering from retinal degenerative diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD). In such patients, it is desirable to reconstruct a useful sense of artificial vision by …
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Spatial properties of photophobia
… electromyography as a function of stimulus size, retinal locus (superior, inferior, temporal, nasal), and retinal eccentricity in three subjects. These results were compared to the same subjects' psychophysically-determined spatial distributions of macular pigment, to examine in detail the …
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Ion flow and membrane tension studies with optical tweezers and nanopipettes
… driven flows, the mechanical behaviour of cell membranes, and the electrical activity from various cells. Voltage driven, or electroosmotic, flow was quantified by measuring the piconewton forces of the flow field outside nanopipettes in diff erent salt conditions using optical tweezers. …
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Towards understanding the mechanisms behind mRNA localisation in growing axons
… regulated in growing axons, affording subcellular autonomy by allowing controlled protein expression in space and time. Different sets of mRNAs exhibit different localisation patterns across the axon. Little is known, however, about how mRNAs move in axons, or how these patterns are …
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Suprachiasmatic nuclei development: A characterization of transcription factors and the influence of retinal innervation and VIP signaling
… models that lacked either Atoh7, necessary for retinal ganglion cell development, or functional VIP peptide or VIP receptor 2: VPAC<sub>2</sub>, Vipr2). We found that maturation of TF expression patterns within the SCN occurred independent of retinal innervation and VIP signaling, suggesting …
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Characterization of the Fast Axonally Transported Proteins in the Rat Optic Pathway
… transport trafficking, the FT of radiolabeled retinal ganglion cell (RGC) proteins in the adult rat optic pathway was studied. The optic pathway model system afforded the opportunity to delineate FT trafficking in the axon from FT trafficking at pre-synaptic terminals. Radiolabel studies of FT …
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Longitudinal Evaluation of Retinal Capillaries in Experimental Glaucoma
… (RPCs) has been hypothesized to play a role in retinal ganglion cell axon degeneration in glaucoma. Previous histological work has shown that structural alterations and losses of RPCs are associated with glaucomatous pathology. However, the lack of longitudinal in vivo data characterizing RPC …
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Development of Polymeric Microparticle-Based Drug Delivery System for Sustained Delivery of H2S for Treatment of Glaucoma
… worldwide and is characterized by progressive retinal ganglion cell degeneration and optic nerve damage. Current therapies primarily target to reduce intraocular pressure (IOP), they remain unsuccessful in preventing neurodegeneration associated with glaucoma progression. Therefore, there is a …
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