Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"retinal development"”.
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The Role of FGF Signaling in Retinal Development
<p>The development of the retina is a precise balance between intrinsic competence and extrinsic factors. This interplay is known to regulate the generation of cell types in the developing retina and similar mechanisms have been found in other regions of the CNS. In the developing retina, FGFs are …
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Role of DeltaC and DeltaD in Zebrafish Retinal Development
… signaling is essential for the maintenance of retinal progenitor cells. However, the specific roles of different Delta ligands on retinal development are not well characterized. The focus of this study was to investigate the specific functions of the Delta ligands, deltaC (Dlc) and deltaD …
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Retinal development and age related degeneration following gestational lead exposure
… lead exposure (GLE) increased and prolonged retinal progenitor cell proliferation in mice, resulting in a dose-dependent increase in two late-born retinal neurons: rod photoreceptors and bipolar cells. The present goals were to examine: 1) the spatiotemporal differentiation and functional …
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Zebrafish Retinal Development and the Effects of Abnormal Light Rearing Conditions
… that the zebrafish may be a good model of retinal development as well. The zebrafish retina develops in a sequential manner and is immature at hatch. Bilotta et al. (1996) also found that the retina was functionally immature in larvae zebrafish. In addition, after exposure to abnormal light …
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The role of integrin mediated adhesion and signaling during Xenopus retinal development
… adhesion and signaling during early Xenopus retinal development. First, I characterized the expression patterns of focal adhesion associated proteins, beta1 integrin, talin, vinculin, paxillin and phosphotyrosine in retinal glial cell line XR1 and in the developing Xenopus retina. These …
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The Role of TGF-B Activated Kinase (TAK1) in Retinal Development and Inflammation
… multiple signaling pathways, is critical to the development of the central nervous system and has been found to play a role in cell death and apoptosis. TAK1 may have the potential to elucidate mechanisms of cell cycle and neurodegeneration. The Belecky-Adams laboratory has aimed to study TAK1 …
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The Albino Mouse Visual System: How Perturbed Retinal Development Leads to Altered Binocular Projections
… of albinism results in hypopigmentation in the retinal pigment epithelium (RPE), the monolayer of epithelial cells surrounding the neural retina. All albino mammals that have been studied display a variety of optic abnormalities, one of which is a reduction in the ipsilateral retinal ganglion …
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Alternative Splicing Factor CELF4 is Implicated in Regulation of Ganglion Cell Differentiation During Murine Retinal Development
… Here we characterize its expression in murine retinal tissue and comment on the role it plays in mammalian retinal development. It has been discovered that mice deficient for this gene have developmental defects in the retina. An enlarged ganglion cell layer in CELF4 mutants is observed at P0. …
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Identification of echinus and characterization of its role in Drosophila eye development
… differentiation and selective cell death in the retinal epithelium. Mutations in the gene echinus cause supernumerary pigment cells due to insufficient cell death. This study reports the identification of echinus and the characterization of its role in Drosophila retinal development. Using a …
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Decoding the Little Skate Retina: Structural Variants and Developmental Dynamics
<p>The retinal development of Elasmobranchs (the superclass comprising sharks, skates and rays) is a poorly understood phenomenon, but it represents a critical component of the broader picture of vertebrate visual development. Evolutionary divergence between these organisms and the mammals is vast, …
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Decoding the Little Skate Retina: Structural Variants and Developmental Dynamics
<p>The retinal development of Elasmobranchs (the superclass comprising sharks, skates and rays) is a poorly understood phenomenon, but it represents a critical component of the broader picture of vertebrate visual development. Evolutionary divergence between these organisms and the mammals is vast, …
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Effects of Restricted Spectral Rearing on the Development of Zebrafish Retinal Physiology
… environments affects both visual behavior and retinal physiology in zebrafish larvae. These studies, however, used only darkness and constant white light as the experimental rearing conditions. The purpose of the present study was to assess the effects on the development of zebrafish retinal …
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Using a seed-network to query multiple large-scale gene expression datasets from the developing retina in order to identify and prioritize experimental targets
… networks that orchestrate the differentiation of retinal progenitors into photoreceptors in the developing retina is important not only due to its therapeutic applications in treating retinal degeneration but also because the developing retina provides an excellent model for studying CNS …
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The Neurogenic Capacity of Müller Glia and Synaptic Remodeling in the Mammalian Retina: Implications for Regenerative Therapies
… based therapies offer hope for the treatment of retinal disease. In the mammalian retina, Müller glia possess some stem cell-like characteristics. However, their capacity for neurogenesis remains limited. To identify factors influencing the neurogenic potential of Müller glia in vitro, a …
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Understanding the genetics and function of complex human retinal phenotypes
… underlying these diseases as well as general eye development. The retina is imaged routinely in the clinic using optical coherence tomography (OCT), providing a non-invasive imaging technique that produces high-resolution, three-dimensional representations of the retina from which measures …
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Characterisation of neural progenitors from the adult retina and ciliary epithelium
… retained by lower vertebrates. However, retinal stem cells have been isolated from the ciliary epithelium of the mammalian retina. Chx10 is a paired-like homeobox transcription factor gene expressed in the presumptive neural retina of the invaginating optic vesicle. The Chx10 gene is …
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Physical Activity-Associated Differences in Placental Lipid Profiles and Docosahexaenoic Acid Uptake: Insights from Lipidomics and an In Vitro Exercise Model
… of particular importance for fetal brain and retinal development, and its proper delivery to the fetus is critical. The influence of gestational PA on these factors has not been explored. Methods: The first objective of this thesis was to characterize the lipid profile of placentas from …
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Neuronal Diversification Within the Retina: Generation of Crossed and Uncrossed Retinal Ganglion Cells
… and their corresponding axon projections. Retinal axon divergence at the optic chiasm midline is key to the establishment of binocular vision in higher vertebrates. In the visual system of binocular animals, the ipsilaterally and contralaterally projecting retinal ganglion cells are …
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Collective Behavior of Drosophila Melanogaster Neural Progenitor and Imaginal Disc Cells within Controlled Microenvironments
… introduced stem-derived cells to recapitulate developmental processes and initiate functional regeneration in different components of the eye. The developing visual system in Drosophila Melanogaster offers a model in which to analyze the associated processes in retinogenesis. The optic nerve is …
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Φυσιολογικός ρόλος του εναλλακτικού ματίσματος του υποδοχέα NMDA στο οπτικό σύστημα
Στόχος: Ο υποδοχέας του γλουταμινικού οξέος ΝMDA (N-methyl-D-aspartate), αποτελεί μόριο-κλειδί που διαμεσολαβεί πολλούς τύπους συναπτικής πλαστικότητας στο κεντρικό νευρικό σύστημα. Στο οπτικό σύστημα η πλαστικότητα ξεκινά στο επίπεδο του αμφιβληστοειδούς χιτώνα. Κατά την ανάπτυξη του …