Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"retinal damage"”.
-
Neuroprotective effects of PACAP, VIP and NAP against hyperglycaemic retinal damage
… process characterizes DR. The reason for the retinal degeneration resides in the metabolic changes caused by hyperglycemia and in the decreased capability of the retina to adapt to this environment. This situation leads to altered expression patterns of neuropeptides, growth and transcription …
-
Laser-induced heating, phase-shift, and damage : measurements and simulations
… the thermal lensing effect. Power and irradiance damage thresholds were calculated for collimated and focused geometries to study the effect in a focusing eye on retinal damage thresholds.
-
The Impact of Iron on Lysosomal Function in the Retinal Pigment Epithelium
… is particularly vulnerable to iron-mediated damage due to its high metabolic rate, yet the mechanisms of iron transport in the retina and how iron can cause retinal damage are fully understood. In this work, we first refine the understanding of iron transport in the retina by examining …
-
Injury Biomechanics of the Human Eye During Blunt and Blast Loading
… injury risk for four eye injuries: hyphema, lens damage, retinal damage, and globe rupture. Injuries sustained were quantified upon direct inspection of the globe following testing. No serious eye injuries were observed for any of the tests and all tests resulted in low predicted injury risks …
-
Cannabinoids: A Novel Treatment Strategy for Retinal Neurodegenerative Disorders
… intraocular pressure (IOP). Glaucomatous damage to the retina and optic nerve progresses even after therapy to maintain normal intraocular pressure (IOP). Topical application of cannabinoids decreases IOP while not affecting blood pressure or heart rate. Based upon their effects on other …
-
Characterization Of Adult Zebrafish Retinal Regeneration Following Two Different Damage Models
… mammals, zebrafish can regenerate all of their retinal neurons through Müller glial cells, which respond to retinal damage by re-entering the cell cycle to create clusters of progenitor cells. The progenitors continue to proliferate as they migrate to the site of damage, where they ultimately …
-
Effect of Drugs on Rabbit Retina
… isolated cone function, but it does not affect retinal morphology. Ranibizumab, bevacizumab, and pegaptanib are inhibitors of the cytokine vascular endothelial growth factor. Pegaptanib and ranibizumab are approved for injection into the vitreous. Bevacizumab is a cancer drug injected off-label …
-
Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration
… neovascularization, inflammation, and retinal damage; however, the disease progression can be deterred through intraocular injections of anti-angiogenic agents. The complications and burden that arise from repetitive injections as well as the difficulty posed by targeting the posterior …
-
Effects of connexin modulators in animal models of retinal degeneration: delivery and treatment efficacy
… particularly its effect on inflammation and retinal function, had not been established. It is proposed that hemichannels confer damage by releasing excessive amounts of ATP that change the tissue environment in pathologies. Pannexin channels are also classically described as ATP releasing …
-
Investigating the integrity of the vasculature and structural relationships of pericytes, astrocytes and the endothelial glycocalyx in an ex vivo hyperglycaemic rat retinal model
… is characterised by the degeneration of the retinal microvascular and neural components that form the blood retinal barrier (BRB), and is due to diabetic metabolic derangements such as hyperglycaemia. The cellular components of the BRB include endothelial cells, pericytes and the glial cells …
-
In vitro evaluation of Ultraviolet Radiation (UVR) exposure of the Retinal Pigmented Epithelium (RPE) and its relevance to Age-Related Macular Degeneration (AMD)
… research into the response of living retinal tissue to UVR in regard to AMD-specific parameters of tissue function. To this end, we sought to explore the response of cultured retinal pigmented epithelium (RPE), the loss of which heralds advanced AMD, to specific wavelengths of UVR …