Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"reticuloendothelial system"”.
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The Effect of Reticulo-Endothelial Blockade on the Capillary Resistance Responses to Cortisone and Sth
A variety of functions has been attributed to the reticuloendothelial system. Among these are phagocytosis of foreign bodies, either micro-organisms or colloids, antibody production, destruction of red blood cells and bile pigment production, some role in lipid and Vitamin A metabolism and …
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Fighting cancer with nanomedicine−drug-polyester nanoconjugates for targeted cancer therapy
… as a novel translational polymeric drug delivery system that can successfully evade non-specific uptake by reticuloendothelial system (RES) and facilitate targeted cancer diagnosis and therapy. By uniquely integrating well-established chemical reaction-controlled ring opening polymerization (ROP) …
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Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer
… suggesting that they were cleared rapidly by the reticuloendothelial system. The antitumor efficacy of paclitaxel-loaded tumor vasculature targeted LCL was compared with paclitaxel-loaded tumor cell targeted LCL. The antitumor efficacy was comparable for tumor vasculature targeted LCL, …
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Polyacrylamide nanoparticle delivery systems in photodynamic therapy
… and retention effect, if sequestration by the reticuloendothelial system (RES) is avoided. This project aimed to develop an efficient drug delivery system based on nano-sized particles. Polyacrylamide nanoparticles were chosen to deliver photosensitisers due to the chemical and biological …
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Polysaccharide-Based Nanocarriers for Improved Drug Delivery
… hydrophilicity that may reduce uptake by the reticuloendothelial system and prolong drug circulation. In this study, we developed PSA-based nanocarriers, specifically micelles and nanoparticles, for improved drug delivery with improved efficacy and minimized toxicity. PSA-based micelle systems …
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An In Vivo Characterization of the Functional Role of Two Novel Genes: StARD5 and ADAM11
… of a floxed mouse allele of the UPR-upregulated, reticuloendothelial gene StARD5, as well as two different transgenic mouse lines, one which expresses the human StARD5 gene in the liver and one which expresses the human StARD5 in the reticuloendothelial system. We show that StARD5 plays an …
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Critical considerations in development of mesoporous silica nanoparticles for biological applications.
… (aggregation) result in rapid uptake by the reticuloendothelial system, a portion of immune system which removes the nanoparticles from circulation before they reach their tumor target. Another hurdle is the possible unintentional toxicity of such nanoparticles. If the designed mesoporous …
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Synthesis, Characterization, and Evaluation of Amphiphilic Cell-Penetrating Peptides as siRNA Delivery Tools for Cancer Therapy
… elimination by the kidney, entrapment by the reticuloendothelial system, sequestration by plasma proteins, endosomal trap, and off-target effects.</p> <p>Several delivery systems and transfection agents have been investigated to address these challenges. Still, most of the systems suffer from …
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Stealth Polymer Conjugates of Biologics
… opsonization that reduces clearance by the reticuloendothelial system (RES) organs, and improved solubility. Unfortunately, PEGylation has several significant limitations, some of which have come to the forefront recently. First, PEG was initially believed to be non-immunogenic. However, it …
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Dextran Magnetite as an NMR Contrast Agent
Made available in DSpace on 2017-07-06T18:42:13Z (GMT). No. of bitstreams: 3 Alameda_Jay_C_Jr_MS.pdf: 36399097 bytes, checksum: a08d9d029c3e486ed573a217b4bbf5e2 (MD5) Alameda_Jay_C_Jr_MS_ABS.pdf: 1261364 bytes, checksum: e54d7b39be48ea31cc1b6086ec21f499 (MD5) license.txt: 4813 bytes, checksum: …
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Investigation of a fusogenic pH-sensitive liposomal system for tumour-targeted intracellular delivery of dinitrobenzamide mustard prodrugs
… nanotechnology using a novel pPSL delivery system to improve tumour selective targeting and cellular uptake of DNBM prodrugs. The features of solid tumour were exploited. A weakly acidic (SN25860) and basic (SN23816) DNBM prodrug were used as model drugs. Methods: A PEGylated (3 mol%), …