Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"response to inflammation"”.
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Microglial activation in the harlequin mouse retina as a mechanism for early retinal degeneration
… of retinal disease remain poorly understood. A model of premature aging, the harlequin mouse, was used to test the hypothesis that parainflammation, a response to inflammation correlates with functional deficits preceding observed structural losses. In vivo retinal imaging showed …
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The role of the Dnmt3aR882H mutation in the evolution of clonal haematopoiesis.
… are very frequent events in clonal haematopoiesis of indeter- minate potential (CHIP), and considered one of the earliest genetic events during the development of haematopoietic malignancies. Individuals with CHIP, in spite of having a normal full blood count are at increased risk of …
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Autoradiographic Localization of Carbachol-Induced Second Messenger Response in the Rat Spinal Cord Following Inflammation.
… central mechanisms of persistent pain using an autoradiographic technique to localize phosphoinositide hydrolysis (PI) in the rat spinal cord dorsal horn. The lateral half of laminae I-II showed the highest levels of baseline PI turnover and carbachol-stimulated PI turnover in normal animals as …
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Stress and inflammation regulate the kynurenine pathway dioxygenases in a glia‐ and tissue‐specific manner
The inflammation and stress responses are intimately related adaptive responses to pathogens or other stressors upsetting our body’s homeostasis. However, when infections or other stressors persist-or are sufficiently traumatic-our normally adaptive responses become maladaptive compromising our …
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RNA-binding proteins mediate anti-inflammatory regulation of vascular disease
… X-related protein (FXR1) as a reciprocal regulator of HuR target transcripts in vascular smooth muscle cells (VSMC). FXR1 was identified as an HuR interacting protein by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The-HuR-FXR1 interaction is abrogated in RNase-treated extracts, …
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Gene expression profiling reveals novel actions of glucocorticoids on immune cells during inflammation
The innate immune response is triggered by bacterial activators such as lipopolysaccharide (LPS). This leads to production of mediators which co-ordinate the body's response to inflammation. In addition to the beneficial effects of such a response to LPS, this activation also accounts for the …
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The expression of potential molecular candidates for chloride ion channels in primary human granulocytes and granulocytic cell lines
INTRODUCTION AND HYPOTHESIS: The project aims to identify potential candidates for chloride (Cl-) ion channels in granulocytes, and granulocytic cell lines. It is hypothesised that Cl- ion channels, in particular hBest1, are implicated in the role of granulocytes in response to inflammation. …
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The Role of LIFR Signaling in Innate Immunity
… localized signals that bone marrow (BM) hematopoietic stem cells (HSCs) and immune cells receive are critical in regulating their responses in the steady state and inflammation. Monocytes are an abundant and key population in the innate immune response that originates in the BM, and they …
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System identification of cortisol secretion : characterizing pulsatile dynamics
Cortisol controls the body's metabolism and response to inflammation and stress. Cortisol is released in pulses from the adrenal glands in response to pulses of adreno-corticotropic hormone (ACTH) released from the anterior pituitary; in return, cortisol has a negative feedback effect on ACTH …
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Forces on a wall-bound leukocyte due to flowing red blood cells
As part of the inflammation response, white blood cells (leukocytes) bind nearly statically to blood vessel walls before they transmigrate through the endothelium and exit the vessel. The inter-cellular interactions between the wall-adhered leukocyte and flowing red blood cells (erythrocytes) play …
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The role of Id2 (inhibitor of differentiation, DNA binding) in dendritic cell development in steady state and inflammation
… cells that capture antigens and migrate to lymphoid tissues where they elicit specific immune responses. Several DC subtypes have previously been characterised, depending on their function and location. Each subtype appears to have a specialised role in both immunity and tolerance. …
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Regulation of The Expression and Lysine Acetylation of Pro-Inflammatory Molecules By Lipid-Modifying Enzyme (LPCAT2) in RAW264.7 Cells
… is a subtype of LPCAT that regulates inflammatory responses to infection by lipopolysaccharides and lipopeptides. LPCAT2 co-localises with TLR4 and prevents its translocation to the signalling site (lipid rafts) of macrophage membranes. The first response to inflammation involves infiltration …
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SIGNALLING TISSUE RENEWAL AND CRYPT SURVIVAL IN THE HUMAN COLONIC EPITHELIUM AND BARRETT’S OESOPHAGUS
… process. The colonic epithelium is organised into millions of invaginations called crypts, each of which represents the self-renewing unit of the tissue. In the mouse, renewal of the intestinal epithelium is regulated by signalling cross-talk between the Wnt, Notch, EGF and TGFβ/BMP pathways. …
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Regulation of VEGFR-3 expression and lymphangiogenesis in normal and inflamed tissues
Elevation of VEGFR-3, the primary mediator of lymphangiogenesis (i.e., new lymphatic vessel formation), is frequently associated with inflammation related to chronic disease and cancer. In the latter case, VEGFR-3 dependent lymphangiogenesis induced by inflamed tumors increases the incidence of …
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Imaging microcalcium in thoracic aortic disease
… in the aortic wall occurs as a response to inflammation, cell stress and death, and its presence is thought to confer a vulnerable disease state in both thoracic aortic atheroma and aneurysm formation. 18F-Sodium fluoride positron emission tomography (PET) identifies …
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Development and validation of quantitative methods for the analysis of clinical biomarkers of iron metabolism applying stable isotopes
… in current clinical practice. The urgent need to determine the values of appropriate clinical parameters (biomarkers) in biological fluids is driving the development of new analytical methodologies capable of providing quantitative, precise, accurate and validated information on the …