Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"respiratory pathogens"”.
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The contribution of respiratory pathogens to Sudden Unexpected Death in Infancy
… mortality in infants less than one year of age. Respiratory infections have been identified as the most frequent cause of death in these infants. Yet, the broad range of respiratory pathogen that might be involved in SUDI is poorly studied. This study aimed to investigate the incidence of the …
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Deciphering the mechanism of foxa2 inactivation by respiratory pathogens in chronically diseased lungs
… especially vulnerable to infection by microbial pathogens. Pseudomonas aeruginosa is an important bacterial pathogen in chronically diseased airways, especially dominant in CF and advanced stages of COPD. Pyocyanin is a redox-active virulence factors secreted copiously in CF and COPD airways by …
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The effect of e-liquids and electronic cigarette vapour extract (ECVE) on key respiratory pathogens
… to evaluate the effect of e-cigarettes on key respiratory pathogens which included S. aureus (SA), P. aeruginosa (PA), H. influenzae (HI), S. pneumoniae (SP) and M. catarrhalis (MCAT).<br/><br/>Results from this study have shown that neat e-liquids can reduce bacterial viability with particular …
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Enhancement of Porcine Alveolar Macrophage Response to Respiratory Pathogens by Dietary Supplementation of Long-chain PUFA.
North Carolina State University Theses Animal Science.
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Loop mediated isothermal amplification based detection of equine respiratory pathogens using a portable, smartphone-based setup
… and reporting of infectious viral and microbial pathogens in a wide variety of point-of-care applications that impact human and animal health. We report the design, construction, and characterization of a multiplexed platform for multiplexed analysis of disease-specific DNA sequences that …
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Deciphering the molecular basis of the global emergence of non-tuberculous Mycobacteria as important human respiratory pathogens
… individuals with pre-existing conditions such as respiratory and immune disorders. There has been a steady increase in the number of NTM infection reports in the past four decades and many of them show resistance to common anti-mycobacterial drugs. It is known that the bacteria manipulate the host …
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Developing Quantitative Methods to Better Characterize Transmission for Enteric and Respiratory Pathogens and Design More-Effective Nonpharmaceutical Interventions.
North Carolina State University Theses Veterinary Medical Sciences.
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Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study
… the interaction of S. pneumoniae with other respiratory pathogens and how such interactions may contribute development of severe disease.
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Multiplexed detection of infectious pathogens using on-chip loop-mediated isothermal amplification and a smartphone
… identification, and reporting of infectious pathogens in a wide variety of point-of-care applications that impact human and animal health. In this work, we report the design, construction, and characterization of a platform for multiplexed analysis of disease-specific DNA sequences that …
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Understanding the molecular mechanism through which aspirated bile triggers chronic Pseudomonas aeruginosa infections in respiratory disease
… a major co-morbidity in CF and a range of other respiratory conditions and is associated with the presence of bile acids in the lungs of CF patients, a consequence of micro-aspiration of refluxed gastric contents. This thesis aimed to investigate the impact that bile exerts on the global lung …
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On Immunological Imprinting
… speed and magnitude. For rapidly mutating respiratory pathogens such as influenza viruses and SARS-CoV-2, subsequent encounters are not to the same antigen, but rather one that has mutated and formed new epitopes. Immunological imprinting (formerly known as original antigenic sin) describes …
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An investigation in the seasonal patterns of bacterial colonisation in childhood pneumonia
… pneumonia. Common to such recognised bacterial pathogens is the occurrence of asymptomatic bacterial colonisation or carriage of the nasopharynx, which in turn precedes disease development and progression. This study investigates the trends and patterns of bacterial carriage in the development …
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Exploring In Vitro and In Vivo Pharmacology of Echinacea Purpurea (L.) Moench
… been used for the treatment and prevention of respiratory tract infections. The medicinal plant has originally been discovered by the Native American population, who squeezed the sap from fresh plant or chewed dried roots. Today, commercially available preparations vary greatly in terms of …
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Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… Moreover, in addition to causing acute disease, respiratory virus infections are often complicated by chronic lung pathologies, such as asthma induction, progression, and exacerbation. We have reported that mice treated with a combination of inhaled Toll-like receptor (TLR) 2/6 and TLR 9 agonists …
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Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… Moreover, in addition to causing acute disease, respiratory virus infections are often complicated by chronic lung pathologies, such as asthma induction, progression, and exacerbation. We have reported that mice treated with a combination of inhaled Toll-like receptor (TLR) 2/6 and TLR 9 agonists …
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Modelling longitudinal data on respiratory infections to inform health policy
… disentangling the contribution of different pathogens and evaluating the effectiveness of an intervention are research questions common to several infectious diseases. The answers to these questions provide the epidemiological understanding to prevent future outbreaks, by informing public …
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Aetiology and presentation of childhood pleural infections in the post-pneumococcal conjugate vaccine era in South Africa
Complications of respiratory infections include pleural effusion (PE), associated with a high morbidity. Differentiating between PE caused by bacterial infections and Mycobacterium tuberculosis (TB) in endemic areas is difficult in children, impacting treatment. We investigated the aetiology of PE …
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The regulation and function of viperin during rhinovirus infection
… role in orchestrating innate immune responses to respiratory viruses, including rhinovirus. Interfacing with inhaled material in the airway lumen, the airway epithelium experiences continuous onslaught from respiratory pathogens. To combat viral infection, cells of the airway epithelium express a …
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Bacterial Outer Membrane Vesicles. Mediators of virulence and antibiotic resistance.
… are Gram-negative bacterial species that cause respiratory tract infections such as acute otitis media and exacerbations in chronic obstructive pulmonary disease (COPD). The aim of this thesis was to investigate what role OMV derived from respiratory pathogens such as M. catarrhalis and H. …
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