Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"respiratory medicine"”.
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Data analysis in respiratory medicine : model selection and classification methods applied to clinical diagnostics
… for the advancement of clinical diagnostics in respiratory <br>medicine. <br> <br>Part I first exposes the clinical problem of incomplete forced expiration manoeuvres, an inconvenience that frequently arises when the lung function of patients with impaired respiration is investigated. We …
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Novel methods within a randomised controlled trial in respiratory disease
… a series of novel methods as solutions in respiratory medicine.<br/><br/>Methods:<br/>A number of studies were embedded within the CLEAR bronchiectasis trial. Studies investigated remote data collection in lung function using patient-led technology, the use of remote patient reported …
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EXPLORING EQUINE ASTHMA: PATHOGENESIS INSIGHTS AND DIAGNOSTIC CHALLENGES
Equine asthma (EA) is a common respiratory syndrome of horses, including a spectrum of chronic inflammatory disorders of the lower airway, which can be classified as mild-moderate (MEA) or severe (SEA), based on clinical severity. Although it is spread worldwide and has been studied for decades, …
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The effect of domestic mechanical heat recovery ventilation on asthma control of patients allergic to the house dust mite
… the University Departments of Architecture, Respiratory Medicine and Immunology, local General Practices, the district general hospital, the local councils and industry. 100 participants completed follow-up. At twelve months, there was a clinically significant improvement in evening peak …
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T-cells in COPD to help or harm? A study of T-cells in COPD patients and related aspects of T-cell function in vitro
Chronic obstructive pulmonary disease, COPD, is manifested by chronic airflow limitation due to inflammation and tissue destruction in the lungs. COPD is caused primarily by smoking and with increasing cigarette consumption in the world, the prevalence for COPD will most probably increase in the …
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The Voice of the Patient
… (PRO) for clinical evaluation in regard to respiratory allergic disease. Two PROs were validated. The first questionnaire was a disease-specific, health- related quality of life questionnaire that had been developed in England for children with multiple allergic diseases. We translated the …
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Midkine - a host defence protein
Every day we encounter many potentially harmful microbes in our environment. The epithelial linings constitute an anatomical barrier protecting us and they also produce antimicrobial polypeptides (AMPs) that act as a chemical barrier. These AMPs are small and positively charged, killing a broad …
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The impact of nocturnal CPAP-treatment on sexuality and closeness in patients with obstructive sleep apnea.
Sleep has a major impact on our wellbeing and how we perform.OSA has an estimated prevalence of 2 % in women and 4 % in male and is characterized by repetitive complete (apnoea) or partial (hypopnoea) cessation of breathing. I wondered how the patients managed sexuality and closeness when suffering …
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The role of a deglycating enzyme ‘fructosamine-3-kinase’ in diabetes and COPD
… (GOLD 2) who were recruited at The Section of Respiratory Medicine, University Hospital of Ferrara, Italy. Those samples were assessed for FN3K expression by means of immunohistochemistry to explore the difference in FN3K activity between those three categories. It was found that the …
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Alternative Lead Systems for Diagnostic Electrocardiography: Validation and Clinical Applicability
The standard 12-lead electrocardiogram (ECG) remains one of the most important and most frequently used tools for diagnosing cardiac diseases, although several different examination modalities in cardio¬logy have been developed over the years. The standard ECG uses 10 electrodes placed on …
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Tissue repair in lung disorders
The remodeling phase of tissue repair in lung disorders such as idiopathic pulmonary disease, asthma, obliterative bronchiolitis, and after lung transplantation is not well understood. One of the key players in fibrosis is the fibroblast and its progenitor, the fibrocyte. The fibroblast is the main …
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Immunopathological and Structural Alterations in Difficult to Control Asthma
Asthma is a chronic respiratory disorder affecting an estimated 300 million people worldwide. Most patients with asthma can be controlled with bronchodilators and low to moderate dose inhaled corticosteroids. However, an estimated 5-10% of the population presents a more troublesome disease, often …
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From sneeze to wheeze: Non-invasive studies on asthma and rhinitis
Asthma and allergic rhinitis are diseases that cause major disability and illness in all ethnic groups and ages. It is well established that allergic rhinitis and asthma are closely linked entities and more than 75 % of the patients with asthma reports concomitant rhinitis. Asthma is also closely …
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New aspects of tissue mast cells in inflammatory airway diseases
Mast cell are found throughout the body, but are especially prominent in tissues that have direct contact with the external milieu such as the skin, gastrointestinal tract and lungs. Mast cells are commonly recognized for their detrimental role in allergic reactions and can, upon activation through …
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Role of Toll-like receptors in airway inflammation
Toll-like receptors (TLRs) are germline-encoded pathogen-recognition receptors that detect different microbial structures and activate the immune system. The human TLR family presently comprises ten members (TLR1-TLR10), each with distinct properties. Although the TLRs protect the host from …
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Assessment of myocardial viability using magnetic resonance imaging
Myocardial infarction (MI) following an acute coronary occlusion is a leading cause of morbidity and mortality. During revascularization, microemboli may complicate treatment and affect cardiac function. The long-term effects of microembolization are not fully elucidated. Following an MI it is …
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New Mediators and Novel Mechanisms in Allergic Airway Inflammation
Hyperresponsiveness and inflammation are major pathophysiological features of both allergic rhinitis and asthma. The mechanisms behind these are not fully understood. The aims of this thesis were to investigate if cytokines involved in the allergic response can induce airway hyperreactivity by …
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Exercise physiology and cardiac function. Aspects on determinants of maximal oxygen uptake
… enlarged athlete's heart and the healthy respiratory response to exercise in both males and females, in order to facilitate the differentiation between the physiologically enlarged heart and the pathologically enlarged heart. Paper I showed that the total heart volume (THV) increases with …
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Antibacterial peptides - key players in host defense at epithelial surfaces
Innate host defense mechanisms at epithelial surfaces are important to prevent bacterial invasion. Streptococcus pyogenes, group A streptococcus (GAS), has an affinity for epithelial cells and cause pharyngitis. During streptococcal pharyngitis, high concentrations of the chemokines CXCL9/MIG, …
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Quantitative and Qualitative Assessment of the Myocardium at Risk
One of the major determinants of the final infarct size during an acute coronary occlusion is the size of the myocardium subjected to ischemia. Identification and quantification of this so-called myocardium at risk in the acute phase of ischemia has been difficult in patients with conventional …
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