Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"respiratory epithelium"”.
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Investigating factors governing cell fate decisions in respiratory epithelium
The maintenance of the airway/respiratory epithelium during adult homeostasis and repair and its construction during embryonic development require tightly regulated cell fate decisions. This regulation takes the form of complex transcription factor and signalling cascades, much of which are …
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The technique of tracheobronchial biopsy in the horse and its application in evaluation of the response of respiratory epithelium to stall confinement
The respiratory epithelial response of the adult horse was evaluated after being housed on pasture and in an enclosed stable for four week periods. six thoroughbred cross horses, ranging from 3 to 6 years old, were housed on a pasture for 2 months, and evaluated at the end of this period. After an …
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Valutazione dell'efficienza, efficacia e sicurezza di vettori lentivirali nel trasferimento del gene CFTR in sistemi modello di epitelio respiratorio in fibrosi cistica
… and they are able to infect quiescent cells like respiratory epithelium cells. Primary goal of the project is concerned with the realization of a lentivirus working live agent, transferring CFTR WT gene, or SHRNA molecules directed against ENAC subunits; ENAC is a sodium channel hyperactive in …
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AN IMPROVED GENOMIC SURVEILLANCE APPROACH TO DISSECT THE SARS-COV-2 PANDEMIC
Genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only approach to rapidly monitor and tackle emerging variants of concern (VOC) of the COVID-19 pandemic. Such scrutiny is crucial to limit the spread of VOC that might escape the immune protection conferred …
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Sequence-Specific Gene Correction of Cystic Fibrosis Airway Basal Cells
… are a multipotent stem cell population of the respiratory epithelium and therefore, their gene correction could provide a long-term, permanent remedy for CF. Delivery of engineered sequence-specific zinc finger nucleases (ZFNs) and single-stranded oligo DNA (ssODN) carrying the correcting …
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The role of E2f4 in cell cycle exit and bone development
… several cell types, including erythrocytes and respiratory epithelium cells. Here, I analyzed a novel role for E2f4 in bone development. I found that mutation of E2f4 causes defects in intramembranous and endochondral bone development. The calvarial bones of the skull exhibit the most severe …
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A Novel Mouse Model of Asthma Induced by Cockroach
… in BAL fluid, and goblet cell hyperplasia of respiratory epithelium, however, did not affect AHR. Endotoxin-depleted CR also attenuated eosinophilic inflammation and lymphocytosis in BAL fluid, but did not affect AHR and IL-13 levels in BAL fluid compared to CR group. AHR, eosinophilic …
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Expanding inducible epithelial resistance against pneumonia: novel virus, novel receptor
… of the innate immune response in the airway epithelium is necessary and sufficient to produce a pathogen-killing but self-protective environment to prevent severe disease. Inducible resistance is pathogen-agnostic and has been demonstrated against an array of respiratory infections. We …
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Ultrastructure and function of respiratory cilia in critical illness
… literature describing the ultrastructure of the respiratory epithelium in this patient group. The principal aims of this study included an investigation of the ultrastructure of the respiratory ciliated epithelium in ICU patients, together with an assessment of the impact of the known risk …
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The Genetic, Molecular, And Cellular Bases Of Unidentified Primary Immunodeficiencies
… individual presented with recurrent severe respiratory infections with RNA viruses including human rhinovirus, coronaviruses (HKU1, OC43, NL63), influenza virus, and respiratory syncytial virus. The mutant protein lost the ability to bind dsRNA and failed to initiate antiviral interferon-β …
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Pathogenic effects of Mycoplasma hyopneumoniae on porcine tracheal organ cultures and neutrophils in vitro, and porcine respiratory goblet cells in vivo
… utilized by this organism to damage ciliated respiratory epithelium were examined using newborn piglet tracheal organ cultures as an in vitro model to measure loss of cilia and/or ciliary activity. The effect of in vivo and in vitro propagation of M. hyopneumoniae strain 232 on cytotoxic …
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3D Nanoscale Architecture and Physiology of the Human Airway Epithelium
… cells into multiciliated cells within the human respiratory epithelium – a tissue barrier crucial for protection against bacteria, viruses, and particulate matter. In this thesis, I present the first isotropic three-dimensional map of the human airway epithelium at the nanometre scale, utilising …
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EFFECT OF NICOTINE ON LUNG S-ADENOSYLMETHIONINE AND PNEUMOCYSTIS PNEUMONIA DEVELOPMENT
… of lung alveolar regions (site of infection) and respiratory epithelium for controls. We found nicotine to cause increased ODC activity in alveolar regions but not airway epithelium; we conclude that tissue specificity likely contributes to the effect of nicotine on "Pneumocystis" pneumonia. Our …
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The pathogenesis of idiopathic pulmonary fibrosis
… epithelial derangement may extend into the respiratory epithelium with release of carcinoembryonic antigen (CEA) in peripheral circulation as evidenced by a significant correlation of raised CEA level and lung function impairment in IPF.These findings provide clinical and molecular evidence …
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Relationship between surfactant alterations and severity of disease in horses with recurrent airway obstruction (RAO)
… is synthesized in the alveoli and lines the respiratory epithelium of the airways. Phospholipids, the main component of surfactant, confer it its ability to lower surface tension and to prevent alveolar collapse. Airway surfactant helps maintain smaller airway patency, improves muco-ciliary …
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Compartmental responses of the respiratory tract to Staphylococcus aureus
… cells and their response to TLR ligands. The respiratory tract itself seems to pose a contradiction given by the clinical observation that its upper portion (nasal compartment) allows the growth of bacteria, acting like a reservoir, whereas the lower portion (lung compartment) reacts with an …
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Haemophilus influenzae adhesins and the innate immune response
… influenzae is a human specific Gram-negative respiratory tract pathogen. Encapsulated H. influenzae strains exist in six different serotypes a-f, of which type b (Hib) is the most virulent. Hib is protected by the polysaccharide capsule when invading the blood circulaton and may cause diseases …