Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"respiratory epithelial cells"”.
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Do respiratory epithelial cells ‘remember’ early life microbial exposure through epigenetic changes?
… following discoveries that many innate immune cells display lasting changes in their responses to challenges as a consequence of previous infections. It was determined that these long-term changes in immune responses were possible due to epigenetic or metabolomic imprinting. This phenomenon was …
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Cationic lipid formaulation of short interference RNA (siRNA) for delivery to respiratory epithelial cells
Cationic lipids are commonly used and relatively safe vectors for plasmid<br/>(pDNA) delivery. In search for an optimal lipid-based formulation for siRNA<br/>delivery to the lungs, cationic lipid-based carriers were investigated for the delivery of siRNA in comparison with pDNA delivery. The aim …
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<i>Haemophilus influenzae</i> modulins in chronic obstructive pulmonary disease airway inflammation
… <em>H. influenzae</em> (NTHi) causes repeated respiratory infections characterized by a brisk inflammatory response that results in the expression and secretion of proinflammatory cytokines. We hypothesized that secreted and cell asssociated NTHi proteins mediate cellular interactions with …
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Isolation of human amniotic stem cells from term placenta and their in vitro differentation in airway epithelium to correct CF phenotype
… chloride channel expressed on the apical side of epithelial cells. Although CF involves many organs with secretory/absorptive properties, including the liver, the main cause of morbidity and mortality is a chronic inflammatory lung disease. Because of its monogenic nature, and since the lung is …
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Immune Transcriptome and B cell receptor repertoire in COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulting in Coronavirus disease 2019 (COVID-19) was declared by the World Health Organization a global pandemic on March 11, 2020. SARS-CoV-2 primarily infects respiratory epithelial cells, and results in a range of clinical …
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Attenuation of Interferon Responses in the Obese Host and Ramifications for Influenza Virus Evolution
… infection, obese animal models and human respiratory epithelial cells were inoculated with influenza viruses to quantify the innate responses. In obese hosts, antiviral effector production, including type I and type III interferons, was consistently blunted across all model systems and …
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Haemophilus influenzae adhesins and the innate immune response
… influenzae is a human specific Gram-negative respiratory tract pathogen. Encapsulated H. influenzae strains exist in six different serotypes a-f, of which type b (Hib) is the most virulent. Hib is protected by the polysaccharide capsule when invading the blood circulaton and may cause diseases …
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Bacterial Outer Membrane Vesicles. Mediators of virulence and antibiotic resistance.
… are Gram-negative bacterial species that cause respiratory tract infections such as acute otitis media and exacerbations in chronic obstructive pulmonary disease (COPD). The aim of this thesis was to investigate what role OMV derived from respiratory pathogens such as M. catarrhalis and H. …
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Tissue engineering of a tracheal substitute
… and characterise the differentiation of human respiratory epithelial cells (REC) cultured on two biomaterial scaffolds. The first scaffold, based on a hyaluronic acid derivative, was observed to be non-adhesive for REC. This lack of adhesion was found to be unrelated to the presence of the …
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Zytotoxizitätsprüfung verschiedener Silbertitanlegierungen auf Titanbasis mittels humaner Osteoblasten
In der vorliegenden Arbeit wurde die Zytotoxizität verschiedener Schichten bestehend aus Silber-Titanlegierungen auf Titanbasis mittels der humanen Osteoblastenzelllinie hFOB 1.19 geprüft. Es sollte der Einfluß des Silberanteils in der Beschichtung auf die Zellen getestet werden. Es wurde die …