Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"respiratory chain"”.
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Biochemical characterization of respiratory chain flavoproteins
… complexes constitute the electron transport or respiratory chain. This thesis will cover the study of three different flavin-containing proteins related to the electron transport chain: • The type 2 NADH dehydrogenase (NDH-2) from Streptococcus agalactiae • The sulfide:quinone oxidoreductase …
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Pathological features of mitochondrial respiratory chain dysfunction
… These processes include ATP generation by the respiratory chain, aspartate synthesis by matrix aminotransferases, and long-chain fatty acid catabolism by the beta oxidation pathway. Given the role of mitochondria in maintaining cellular physiology, mitochondrial dysfunction often leads to …
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Analysis of the role of Mdm38 in respiratory chain biogenesis
Die vorliegende Arbeit beleuchtet die Funktion des mitochondrialen Proteins Mdm38 bei der Biogenese der Atmungskette in der Hefe Saccharomyces cerevisiae. Es ist ein Homolog des humanen Proteins LETM1, das mit der Pathogenese des Wolf-Hirschhorn-Syndroms in Zusammenhang gebracht wird. Mdm38 wird …
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New diagnostic methods for respiratory chain defects in mitochondrial (encephalo)myopathies
Contains fulltext : mmubn000001_231574754.pdf (Publisher’s version ) (Open Access)
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Effect of experimental complex III deficiency on respiratory chain assembly and function
The assembly of respiratory chain complexes in the mitochondrial inner membrane requires specific factors. Once assembled to form a mature functional complex, complex III (CIII) is a dimer consisting of two monomers, each with eleven subunits. To date, seven assembly factors for CIII are known, of …
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Respiratory chain deficiency alters cellular proteostasis and triggers Alzheimer’s disease-like tau alterations
… we provide evidence that reduced mitochondrial respiratory flux leads to AD-like tau alterations, including changes in splicing, conformation and oligomerization. Alzheimer’s disease cybrids recapitulate disease relevant tau alterations. Further experiments suggest mitochondrial function affects …
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Inhibition of the Toxoplasma gondii replication by inhibition of the mitochondrial respiratory chain
Der obligat intrazelluläre Parasit Toxoplasma gondii gehört ebenso wie Plasmodium falciparum zu den Apicomplexa. Das in den letzten Jahren gehäufte Auftreten von Resistenzen gegenüber gängigen Therapeutika macht die Erforschung neuer medikamentöser Angriffspunkte für diese Parasiten notwendig. Die …
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The Cytochrome D Oxidase Complex and The Aerobic Respiratory Chain of Escherichia Coli (Bacteria, Bioenergetics)
Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs
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Characterization of alternative NADH dehydrogenases in the respiratory chain of Toxoplasma gondii as a novel drug targets
Das singuläre Mitochondrium der schnell replizierenden Tachyzoiten von Toxoplasma gondii generiert ein Membranpotential, über dessen Beitrag zum Energiestoffwechsel des Bradyzoiten- oder Ruhestadiums des Parasiten bisher wenig bekannt ist.Die steady state mRNA-Konzentration von 11 nukleär-kodierten …
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Molecular Studies of the NADH:ubiquinone Oxidoreductases and Thebo-Type Terminal Oxidase of the Aerobic Respiratory Chain of Escherichia Coli
The respiratory chains of aerobic organisms are composed of several membrane-bound proteins, which are responsible for the majority of energy production which occurs in living cells. Three such proteins, two NADH:ubiquinone oxidoreductases and a terminal ubiquinol oxidase, from the respiratory …
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Regulation of fatty acid and mitochondrial respiratory chain genes in a hypobaric hypoxia-induced right ventricular hypertrophy rat model
Includes bibliographical references.
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Functional and Pathophysiological-morphological Correlates of Neurodegenerative Diseases
… and database summary. Changes in the amount of respiratory chain complex I and respiratory chain complex IV in buccal ep- ithelial cells of Huntington's disease patients are described. The insufficient power of optical coherence tomography as a biomarker in Huntington's disease is demonstrated. …
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Metabolic and Kinetic impacts of the auxiliary energy source in model chemolithoheterotrophic Bacteria
… as many reducing equivalents to fuel the respiratory chain and can instead <br/>redirect that material into anabolic reactions to generate more biomass. Many aspects of this metabolism remain poorly understood due to the difficulty in observing genuine chemolithoheterotrophy, with …
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Purification and Characterization of the Cytochrome-O Containing Terminal Oxidase of Escherichia Coli
The function of the aerobic respiratory chain of E. coli is to convert the energy released by the transfer of electrons from substrate molecules to oxygen into a proton gradient that can be used by the cell for ATP synthesis, locomotion and active transport of ions and molecules into and out of the …
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Spectroscopic analysis and dynamics of ligand binding to bacterial oxidases
The aerobic respiratory chain of Escherichia coli contains two terminal oxidases, the cytochrome bd complex and the cytochrome bo complex. Each of these enzymes functions as a ubiquinol oxidase and reduces molecular oxygen to water. Although the two enzymes perform the same function they do not …
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Molecular genetic studies of the cytochrome o terminal oxidase complex in Escherichia coli
… oxidase complex is a component of aerobic respiratory chain of Escherichia coli. This enzyme catalyzes the oxidation of ubiquinol-8 to ubiquinone-8 within the cytoplasmic membrane and the concomitant reduction of O$\sb2$ to H$\sb2$O. Cytochrome $o$ oxidase has been purified and shown to …
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The Effects of Neuropathy-Inducing Organophasphate Esters om Chick Dorsal Root Gangli Cell Cultures
… of mitochondrial function, mitochondrial respiratory chain reactions were measured. In situ evaluation of ATP production measured by bioluminescence assay showed decreased ATP concentrations in neurons treated with PSP and mipafox, but not paraoxon. This low energy state was present in …
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Localization of the prosthetic group ligands of cytochrome o terminal oxidase complex of Escherichia coli
… of two terminal oxidases present in the aerobic respiratory chain of E. coli. The cytochrome o complex has been purified and found to contain two protoheme IXs and one copper atom. Subsequently the gene encoding the cyo operon has been cloned. The research presented in this thesis focuses on the …
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