Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 165 for “"resistant bacteria"”.
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Antimicrobial Polymers as Adjuvants/Synergists of Antibiotics to Combat Multidrug-Resistant Bacteria
The emergence of multidrug-resistant (MDR) bacteria due to the overuse and misuse of antibiotics in the medical and agricultural sectors has now become a critical global healthcare issue. Antimicrobial peptides (AMPs) and synthetic mimics thereof have shown promise in combating MDR bacteria …
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The relevance of bacteriophage therapy in the era of antibiotic resistant bacteria
… resistance and a dwindling pipeline of new antibacterial drugs, this thesis set out to examine the potential of bacteriophage (phage) therapy as an alternative or complementary means of treating bacterial infection. Phage therapy is used as a frontline antibacterial therapy in the former Soviet …
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An assessment of antibiotic resistant bacteria in biosolid used as garden fertilizer
… Cheney Wastewater Treatment Plant and antibiotic resistant gram negative bacteria were isolated from it. Bacteria isolated from these samples were resistant to tetracycline, ampicillin, streptomycin, kanamycin and chloramphenicol. Tetracycline resistant bacteria were isolated on MacConkey's agar …
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Investigation of the prevalence of antibiotic resistant bacteria and their genes in wastewater
… effects includes the development of antibiotic resistant microorganisms, which in turn makes the selection of appropriate antibiotics for particular infections difficult. Therefore, the presence and the prevalence of antibiotics in wastewater were investigated in this study and resistant …
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Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
… and other ESKAPE pathogens (including carbapenem-resistant Acinetobacter baumannii). Interestingly, these analogues were resistant to enzymatic degradation in the presence of recently reported D-stereoselective peptidases. <br/><br/>Secondly, brevicidine represents a promising candidate for …
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Molecular Profiling of Antibiotic Resistant Bacteria and Genes in Raw and Drinking Water
Antibiotic resistant bacteria and antibiotic resistant determinants are regarded as emerging public health threats in drinking water systems. Heterotrophic Plate Count bacteria in distribution pipes are used as direct parameters to assess the conditions of water in distribution systems. Moreover, …
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Small Molecules and Their Conjugates with Peptides: Chemical Strategies to Tackle Resistant Bacteria
… selective way, or discovery of new compounds and bacterial targets. This thesis will cover two projects that have tried to address the latter two strategies. The first part focuses on a bacterium with robust resistance mechanisms, *Pseudomonas aeruginosa*, and how it could be targeted with two …
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The development of deoxynybomycins as potent and selective antibiotics against fluoroquinolone resistant bacteria
Antibiotic-resistant bacterial infections pose a real and increasing threat to public health and welfare. As bacteria continue to develop and spread resistance to currently used antibiotics it is of the upmost importance to develop new classes of antibiotics to combat them. Deoxnybyomycin (DNM), …
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Genome scale metabolic modelling to identify metabolic responses of resistant bacteria to antibiotic challenges
… for identifying metabolic drug targets in resistant pathogenic bacteria. In this thesis, genome-scale metabolic modelling (GSMM) was applied to identify antimicrobial drug targets. Experimental data from transposon mutant libraries grown in presence of tilmicosin, a macrolide antibiotic was …
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Antimicrobial resistant bacteria and genes in selected surface water bodies of the North West Province
… antimicrobial (metals and antibiotics) resistant heterotrophic plate count (HPC) bacterial levels in the mining impacted WFS and receiving Mooi River (MR) system and to identify and characterize multiple antibiotic resistant (MAR) bacteria based on their resistance levels and detection …
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Antibacterial activity of the crude extract and fractions of spirostachys africana against multi-drug resistant bacteria
… specifically those caused by multi-drug resistant bacteria in the last decade has made it a necessity to investigate a variety of antimicrobial drug sources, such as plants. Medicinal plants have played a significant role in drug discovery for western pharmaceuticals recently and have …
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Effect of Composting on the Prevalence of Antibiotic Resistant Bacteria and Resistance Genes in Cattle Manure
… of associated diseases. The rise of multidrug resistant pathogens threatens a return to the pre-antibiotic era where even the most common infections may be impossible to treat. It is estimated that the majority of global antibiotic use, and use in the U.S., is dedicated towards livestock, where …
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Effect of Standard Post-harvest Interventions on the Survival and Regrowth of Antibiotic-Resistant Bacteria on Fresh Produce
… vegetables to serve as a vehicle for antibiotic -resistant bacteria is poorly understood. Antibiotics and antibiotic-resistant bacteria have been shown to persist in manure of animals administered antibiotics, and in compost generated from this manure, where there is the potential for their …
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The Synthesis and Biological Evaluation of Narrow-Spectrum Antibiotics and Antibiotic Adjuvants as Strategies to Combat Antibiotic Resistant Bacteria.
North Carolina State University Theses Textile Engineering, Chemistry and Science.
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Fate and transport of antibiotic resistant bacteria and resistance genes in artificially drained agricultural fields receiving swine manure application
… regarding levels of antibiotics and antibiotic resistant bacteria in their excrement. Application of swine manure to agricultural fields as fertilizer creates a pathway for antibiotic resistant bacteria and their associated resistance genes to enter the environment. This study monitored …
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Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
… (RCFs) act as reservoirs for multidrug-resistant organisms (MDRO). There are scarce data on colonisation with MDROs in Africa. We aimed to determine the prevalence of MDROs and C. difficile and risk factors for carriage amongst residents of RCFs in Cape Town, South Africa. Methods We …
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Surface Engineered Novel Patterned Polymers to Remove Pathogenic Biofilms from Human Skin. Effective Removal of Antimicrobial Resistant Bacteria from Chronic Wounds
… triclosan was not cytotoxic against either bacteria or primary cultures of human dermal fibroblasts using Water Soluble Tetrazolium Salts (WST-1) assay. High performance liquid chromatography analysis highlights low level of triclosan release from the PDMS. Bacterial infection in co-culture …
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