Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"resistance to apoptosis"”.
-
Resistance to Apoptosis in Smooth Muscle Cells and Stent-Induced Stenosis in Coronary and Peripheral Arteries
… disease process and the cells that contribute to it would aid in the development of treatment options. The restenotic process involves the proliferation, apoptosis and migration of vascular smooth muscle cells (VSMCs). Apoptosis has been shown to be an integral part of lesion development in …
-
Regulation of apoptosis and desmosomes by RhoE
… keratinocyte proliferation, differentiation, and apoptosis be precisely regulated and a failure to regulate these processes is a feature of many skin diseases. Although the precise mechanism by which epidermal homeostasis is regulated is still far from clear, much progress has been made in the …
-
Investigation of the Biological Effects of Rosemary (Rosmarinus Officinalis L.) Extract in Human Lung Cancer Cells
Cancer cells display enhanced growth rates and a resistance to apoptosis. Lung cancer accounts for the most cancer related deaths and non-small cell lung cancer (NSCLC) represents an aggressive form of lung cancer, accounting for almost 80% of all lung cancer cases. The phytochemical rosemary …
-
Polymer-tethered epidermal growth factor as an inductive biomaterial surface for connective tissue progenitors
Connective tissue progenitors (CTP) can act as a pluripotent source of reparative cells during injury and therefore have great potential in regenerative medicine and tissue engineering. However, the response of CTP to most growth factors and cytokines is unknown. Many envisioned applications of …
-
The role of cad,flash and fam129b in cancer cell survial and apoptosis
<p>Apoptosis is a normal process in the human body. However, apoptosis is desregulated in cancer cells. Most cancer cells gain resistance to apoptosis, leading to uncontrolled proliferation. In this dissertation, we identified three proteins, associated with apoptosis pathway. 1) CAD, a large …
-
Celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
Various cancer cells are resistant to chemotherapeutic drugs-induced apoptosis. Thus, cancer cells that have acquired resistance to apoptosis need novel strategies for inducing non-apoptotic cell death. Paraptosis is a kind of non-apoptotic cell death and characterized by extensive vacuolization …
-
Existence of Inhibitor of Apoptosis in Tumor Exosomes
… (5FU) are used clinically. However, resistance to these antimetabolites remains a problem highlighting the need to discover and develop new antimetabolites that will improve a patient’s overall survival. Cancer is a disease that has acquired numerous molecular, biochemical and …
-
The Alpha7beta1 Integrin in Skeletal Muscle and Muscular Dystrophy
… promotes myoblast adhesion, proliferation and resistance to apoptosis without affecting differentiation. In addition, 8-fold more alpha7 integrin in skeletal muscle is not toxic and has no adverse effects in alpha7 integrin transgenic mice. Moreover, enhancing alpha7 integrin only minimally …
-
Targeting c-Met for therapy
c-Met is a tyrosine receptor kinase which is activated by its only ligand, the hepatocyte growth factor (HGF). Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met and HGF knock-out mice are …
-
The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
Fibroblasts are important regulators of inflammatory processes. The phenotype of fibroblasts differ according to anatomical site which may dtermine immune functions such as leukocyte accumulation and predilection for inflammatory disease in certain tissues. This thesis describes the expression …
-
The Role of p66Shc in Stem Cells: Signalling, Identity and Apoptosis
Adaptor proteins of the Shc family link receptor tyrosine kinases (RTKs) to downstream signalling, thereby shaping cell fate decisions. While the canonical isoforms p52Shc and p46Shc act as Ras–MAPK transducers, the longer p66Shc isoform harbours an additional CH2 domain that confers distinct …
-
Role of Hypoxia-inducible Factor in Kidney Cancer
Cellular adaptation to conditions of stress is critical to the survival of all organisms. In mammalian cells, reduced oxygen availability, or hypoxia, triggers a myriad of alterations within molecular pathways aimed at ensuring sustained viability and functionality of vital organs. The master …
-
A Novel Function For 12-Lipoxygenase In C-Met And Integrin β4 Axis Crosstalk
… Invasion can be regulated by the Met receptor tyrosine kinase (c-Met), integrin beta4, and the lipid enzyme, 12-Lipoxygenase (12-LOX). Therefore we sought to determine if beta4, c-MET and 12-LOX comprise a signaling axis. c-Met is implicated in cancer cell dissemination through regulation …
-
Two molecular mechanisms of apoptosis resistance
Many cancer cells develop resistance to apoptosis. It is important to understand how this phenotype develops, so that these cancers can be effectively treated. The results presented in this dissertation describe two molecular mechanisms of apoptosis resistance. A mouse keratinocyte model system …
-
The role of 4-hydroxynonenal in cellular signaling mechanisms
… membrane lipids. The downstream effects of the autocatalytic lipid peroxidation (LPO) cycle are widespread and involve several processes. Using lens epithelial cells (HLE B-3) and retinal pigment epithelial cells (RPE28 SV4) as models, in proposed studies we addressed the hypothesis that a …
-
Deubiquitinating Enzymes Promote Cancer Progression and Metastasis Via Regulating Protein Stability
… Deregulation of DUBs contributes substantially to tumor formation and progression, and therefore targeting DUBs may be a promising cancer therapy strategy. My dissertation focuses on identifying the DUBs of EZH2 and SNAI1, two proteins critical for cancer progression and metastasis, and …
-
Overcoming radioresistance by targeting p21 in cancer
Radiation therapy is one of the most effective cytotoxic therapies to treat localized solid cancers, with external beam radiation and brachytherapy being the most used approach in clinical practice. Proton and charged particle therapy represents a promising advancement in the field, allowing for …
-
Correlation of Cyclooxygenase-2 and Microvessel Density with Prognosis in Transitional Cell Carcinoma of the Upper Urinary Tract
… by affecting tumor cell proliferation, resistance to apoptosis, angiogenesis, and tumor invasion in several types of cancers. However, studies about COX-2 expression in transitional cell carcinoma of the upper urinary tract have been limited. In this study, the relationship of COX-2 …
-
DNA-damage-mediated remodeling of normal and tumor microenvironments modulates cell survival
… involve the systemic administration of genotoxic compounds that induce cancer cell death via well-established DNA damage response signaling networks. While modern chemotherapeutic regimens can be curative, chemotherapeutic drug resistance remains a major clinical problem. This drug …
Page 1 of 2