Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 181 for “"resistance mechanisms"”.
-
INHIBITOR RESISTANCE MECHANISMS AND INHIBITOR DESIGN IN ¿¿-LACTAMASES
Antibiotic resistance is an ever-present problem and is a natural result of evolution; however, it is anticipated that we may exhaust our antibacterial options if new antibiotics are not developed at the speed required by bacterial evolution. ¿¿-Lactams are commonly prescribed antibiotics and …
-
Detection And Characterization of Insecticide Resistance Mechanisms in Culex Tarsalis
<p>Insecticide resistance in disease-transmitting arthropods has become a serious hindrance for successful vector control. Mosquitoes, in particular, are notorious vectors of potentially deadly diseases like malaria, dengue fever, and West Nile virus. Anopheles gambiae and Culex quinquefasciatus …
-
Investigating antimicrobial resistance mechanisms in Neisseria gonorrhoeae using peptide probes
The continuing evolution of antibiotic resistance strains of Neisseria gonorrhoeae coupled with the paucity of new antimicrobial agents makes the treatment of gonococcal infections challenging. A major cause of resistance is the expression of a multidrug efflux pump termed MtrCDE, which exports a …
-
[EMBARGOED] Analysis of cereal cyst nematode resistance mechanisms in barley
… approach for nematode management and four resistance loci, Rha1, Rha2, Rha3 and Rha4, have been mapped. The Rha4 locus was mapped in the Galleon/Haruna Nijo population to chromosome 5H and since Rha2 and Rha4 provide the most effective resistance against the Australian H. avenae pathotype …
-
Antimalarial Drug Resistance: Mechanisms of Emergence in Low-Transmission Settings
Antimalarial drug resistance is a major factor affecting global malaria control, causing treatment failure and significant morbidity and mortality. Resistance has historically emerged in low-transmission areas before spreading to high-transmission areas, and there is consequently widespread …
-
Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat
… eusocial, cold-blooded and with remarkable resistance to hypoxia, hypercapnia and acid-induced pain. Furthermore, NMRs are exceptionally long-lived and extremely cancer resistant. Few studies have attempted to explain the reason behind the NMR’s cancer resistance, but most prominently Tian …
-
Macrophage-mediated resistance mechanisms against MAPK inhibitory by cancer therapeutics
… great headway has been made on characterizing mechanisms of resistance, understanding the full influence of complex intercellular interactions on drug resistance remains a challenge. Here, we combine computation with experiment to investigate the cellular and molecular contributions of the …
-
Identification and Targeting of Therapeutic Resistance Mechanisms in Inflammatory Breast Cancer
… program. The development of therapeutic resistance is a significant barrier to successful treatment in IBC, and thus, strategies targeting the mechanisms that drive drug resistance could prevent or reverse therapeutic resistance, significantly improving patient prognosis. Based on …
-
Winning Well: Civil Resistance Mechanisms of Success, Democracy, and Civil Peace
… indicate that revolutions of non-violent civil resistance lead to more democratic and peaceful political transitions than either violent revolutions or elite-led political transitions. However, this general trend has not been disaggregated to explain the many prominent cases where nonviolent …
-
Targeting Stromal-Mediated Resistance Mechanisms in Oncogenic KRAS-Driven Pancreatic Ductal Adenocarcinoma
… KRAS-targeted therapies, the rapid emergence of resistance mechanisms limits their clinical efficacy. This dissertation investigates three interconnected aspects of PDAC biology and therapeutic targeting in the context of oncogenic KRAS. First, the thesis demonstrates that stromal-derived …
-
GENOMIC AND PHYSIOLOGICAL INSIGHTS INTO BACTERIAL HEAVY METAL RESISTANCE MECHANISMS FOR ENVIRONMENTAL DECONTAMINATION
… and plants have evolved a range of mechanisms to tolerate, transform and immobilize these pollutants, offering opportunities for sustainable bioremediation strategies. The aim of this PhD thesis was to investigate how bacteria can contribute to the removal and detoxification of heavy …
-
The Emergence of Diverse Drug-Resistance Mechanisms from Drug Tolerant Cancer Persister Cells
… towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity and clinical relevance of drug-resistance mechanisms that can expand from a persister bottleneck is unknown. Here, we compared persister-derived, erlotinib-resistant colonies that arose from a single, …
-
Investigation of Clinically Relevant Fluconazole Resistance Mechanisms in the Fungal Pathogen Candida parapsilosis
… infection. Until recently, rates of fluconazole resistance among C. parapsilosis isolates were relatively low, therefore the determination of clinically relevant resistance mechanisms in C. parapsilosis isolates were primarily presumed from the observations of Candida albicans. Gain-of-function …
-
Unveiling Immune Checkpoint Therapy Resistance Mechanisms In The Tumor Microenvironment Using High-Dimensional Analyses
… ductal adenocarcinoma (PDAC), which exhibit resistance to this therapy. To overcome this challenge, it is crucial to understand the underlying mechanisms that determine tumor response to ICT and develop rational therapeutic combinations. The tumor microenvironment (TME), including suppressive …
-
Molecular Analysis of Oomycete Pathogens to Identify and Translate Novel Resistance Mechanisms to Crops
… a system to identify potential new and durable resistance (R) genes against P. sojae in soybean germplasm. We developed a system to screen soybean germplasm for genes that recognize core Phytophthora sojae RXLR effectors that are conserved within the pathogen species and essential for virulence. …
-
Dichlorodiphenyltricholorethane (DDT) resistance mechanisms in Drosophila melanogaster and applications for the cowpea pest Clavigralla tomentosicollis
Control of insects by insecticides has led to resistance in both medical and agricultural pests as well as health and environmental concerns, and improved insect pest management (IPM) programs are necessary. The arrival of next-generation sequencing (NGS) and lowered sequencing costs provides the …
-
Drug resistance mechanisms and drug design strategies for human immunodeficiency virus and hepatitis c virus proteases
… to bind the substrate. Besides the study of drug resistance mechanisms, two drug discovery methods have been carried out in the study. One method is the modification of a current drug, lopinavir. The potency of the lopinavir analog against the MDR HIV-1 protease increases. The other method is the …
-
Turfgrass species composition, resistance mechanisms, and management strategy impacts on brown patch incidence and weed encroachment
Tall fescue (Festuca arundinacea Schreb.) has great utility as a low maintenance turfgrass in the northern and transition zone regions of the United States. However, it is difficult to successfully maintain tall fescue of high quality over consecutive summers because of its susceptibility to the …
-
A feasibility study of chemosensitivity testing in primary cultures from malignant gliomas, and analysis of drug resistance mechanisms
… response is limited by the development of drug resistance. A study was undertaken to investigate the feasibility of providing information about tumour chemosensitivity in vitro by culturing glioma tumour cells in a hospital setting and performing chemnosensitivity assays on them using five …
Page 1 of 10