Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"resistance mechanism"”.
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Leucyl-tRNA synthetase: dynamic subcellular relocalization and drug resistance mechanism
… post-transfer editing. The benzoxaborole’s mechanism of action capitalizes upon one of these editing active site states. Evolution of this tunable editing mechanism in eukaryotic and archaeal LeuRSs is proposed to enable precise control of aminoacylation fidelity. The aaRSs have also been …
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Characterization of P-glycoprotein expression as a multixenobiotic resistance mechanism in fish
… (P-gps) are responsible for multidrug resistance (MDR) phenotypes in tumor cell lines. P-glycoproteins function as energy dependent efflux flippases that prevent the cellular accumulation of a wide variety of compounds. We characterized P-gp expression in populations of several fish …
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In vivo studies of suspected mechanisms of DDT-resistance in Blattella germanica (L.)
… is not thought to be related to the DDT resistance mechanism in this insect. Susceptible and resistant cockroaches are both capable of converting DDT to dicofol which was the only metabolite observed. The conversion rate is somewhat faster in the resistant strains than in the susceptible …
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Investigating naturally evolved Varroa destructorresistance in Apis mellifera honey bees : hostbehavioural traits and parasite reproductivebiology
… an increasing number are evolving mite-resistance and are thus surviving without intervention. Here we investigated reduced mite reproductive success (a well-established resistance mechanism) and two host behavioural traits, recapping and infested brood removal, to ascertain their roles …
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Targeting anti-androgen resistance in prostate cancer using preclinical models with physiological nutrient levels
… 60% of patients will develop Enzalutamide resistance which is currently incurable. Since AR signalling regulates metabolism, a hallmark of cancer, we set out to characterise metabolic Enzalutamide resistance mechanisms that could be therapeutically exploited. However, therapeutic …
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Detection of Plasmid-Mediated AmpC b-Lactamases
… as a research tool for the detection of this resistance mechanism but is not yet available for routine use. Because of the lack of PCR and the difficulty of current detection methods, organisms producing these types of b-lactamases often go undetected and have therefore been responsible for …
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Mechanism of Resistance in Common Ragweed to PPO-inhibiting Herbicides
… Only four weed species have been documented with resistance to this herbicide class. Waterhemp was the first weed species documented with PPO-resistance, which was due to a single codon deletion in a dual-targeting gene known as PPX2L. Common ragweed, from Delaware, was the third documented weed …
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Characterizing Oxadiazon Resistance and Improving Postemergence Control Programs for Goosegrass (Eleusine indica) in Bermudagrass (Cynodon spp.)
… accession in Richmond, VA and characterize the resistance mechanism if present. The SR accession showed a hypersensitive response to oxadiazon treatment and reached maximum electrolyte leakage quicker than the susceptible (S) accession, but had significantly lower electrolyte leakage indicating …
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Mechanisms and control of waterhemp populations resistant to group 15 herbicides
… seed dormancy, and an ability to evolve resistance to herbicides from multiple site-of-action groups. These and other characteristics allow waterhemp to effectively interfere with row crops and reduce seed yield potential. Waterhemp is resistant to herbicides from seven site-of-action …
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Cloning and characterization of AdeMNO RND efflux pump of Acinetobacter baumannii
… from service in Iraq and Afghanistan. Antibiotic resistance of A. baumannii has limited the number of active antibacterial, making very difficult to treat these types of infections. This work investigated the role of Resistance-Nodulation-cell Division (RND) efflux pumps in the antibiotic …
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Herbicide resistance in kochia and wheat: the loss and gain of weed control tools for wheat production
… and very efficient, they are prone to herbicide resistance evolution in weeds. Herbicide resistance evolution is the most pressing issue facing weed scientists, currently. As researchers scramble to develop new weed control technologies, herbicide resistance traits enable the use of herbicides in …
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Leveraging Single Cell Technologies For The Characterization and Treatment of Refractory Pancreatic Cancer
… to a panel of PDO samples to explore adaptive resistance mechanisms of PDAC lesions following administration of epigenetically-modifying therapeutic agents (HDAC inhibitors). I describe a novel HDACi resistance mechanism of AP1 activation, which can be intercepted by using an AP1 inhibitor in …
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Biochemical and molecular basis for metabolism-based atrazine resistance in Amaranthus tuberculatus
… that elevated rates of metabolism may be a major resistance mechanism. My objective was to utilize traditional protein purification techniques combined with proteomic methods to further investigate the hypothesis that enhanced metabolic detoxification of atrazine, catalyzed by distinct GST …
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Measuring Single Cell Responses to Lapatinib In A Heterogeneous Population
… challenge with targeted therapy is the acquired resistance in the cancer cells to these therapies, quite often very rapidly in the course of a few months. One of the major targets in cancer has been the EGFR/ErbB2 network in breast and other cancer types. Prior work from our lab and others have …
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Quantitative analyses to study tumor clones dynamics and tumor heterogeneity
… emerge under treatment pressure and as drug resistance mechanism. The work I present is relevant to the context of precision oncology that exploits detailed patient-specific molecular information to diagnose and follow cancer progression with the ultimate goal of promptly guiding treatment …
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Understanding the Genome-Wide Response of Streptomyces coelicolor to the Glycopeptide Antibiotic Teicoplanin
… and weakening the cell wall. A general resistance mechanism to these antibiotics requires a core set of genes, vanRSHAX, that detect a glycopeptide (VanS) and upregulate genes (VanR) which orchestrate the remodelling of D-Ala-D-Ala on lipid II to D-Ala-D-Lactate (VanHAX), reducing …
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Genome scale metabolic modelling to identify metabolic responses of resistant bacteria to antibiotic challenges
Antimicrobial Resistance (AMR) is one of the most alarming public health threats being faced by humanity in present times, in every aspect from economic losses to social instability. The pace of antimicrobial target research is being overtaken by the pace of resistance developing among disease …
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Non-target-site resistance to ALS inhibitors in waterhemp
… cropping region. The evolution of herbicide resistance and multiple resistance mechanisms within the species is one of the major properties making it difficult to control, and ALS-resistant waterhemp populations have been found and studied considerably. A waterhemp population (designated MCR) …
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Population genetics of herbicide resistance in waterhemp
… been identified throughout the Midwest and the mechanism of resistance in populations from Illinois was previously determined to result from a 3 base pair deletion in the protoporphyrinogen oxidase (PPO)-encoding gene, PPX2. The deletion results in the loss of glycine at position 210 (ΔG210). …
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Resistance to anthracnose leaf blight in sorghum
… the pathogen. Qualitative and quantitative host resistance has been reported for anthracnose leaf blight. However, the evolving nature of the pathogen increases the need to identify more resistance sources that are effective against isolates collected from different locations. In addition, little …
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