Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"resistance arteries"”.
-
The Impact of Outward Remodeling on Vasodilation in Skeletal Muscle Resistance Arteries
… characterized by narrowing of the peripheral arteries due to the accumulation of atherosclerotic plaque in the inner lining of the vessels, which disrupts blood flow to downstream tissues. Blood can be redirected into collateral vessels, natural bypasses around arterial occlusions, causing …
-
Investigation of Hydrogen Peroxide/Reactive Oxygen Species-Related Signaling on Vasoactive Responses in Myogenic Resistance Arteries
… hyperpolarization in myogenically-active resistance arteries, and its contribution to the responses evoked by established vasoactive agents. In particular, I hypothesize that H2O2 and/or ROS serve as physiologic, vasoactive agents in myogenically-active resistance arteries in normal tissue …
-
Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In addition, patients with giant cell arteritis (GCA) were also investigated because of the massive inflammatory activity in affected vessels. For functional …
-
Studies of the renin angiotensin system in the human vasculature
… using wire myography were performed in human resistance arteries from normal subjects, obtained by subcutaneous gluteal at biopsy. In these vessels, AI stimulated a contractile repose that was dependent on activation of the AII type 1 receptor (ATIR). Thus, conversion of AI to AII can occur …
-
The role of spontaneous bursts of muscle sympathetic nerve activity in mediating peripheral vascular responses and cardiovascular hemodynamics in resting man
… on forearm and leg skeletal muscle blood resistance arteries that occur in close association with vasoconstriction of the systemic vasculature, to subsequently increase arterial blood pressure during rest. Vasoconstriction was greater in leg resistance arteries compared to that observed in …
-
Relaxin: a new cardiovascular hormone in humans? Comparative potency and mechanisms of action
… the effects of relaxin in small human resistance arteries ex vivo using wire myography obtained from gluteal biopsies taken from patients with coronary heart disease (CHD) and normal left ventricular systolic function. We also studied the same effects in larger calibre arteries …
-
Effects of an Endothelial Cell-specific PAR2 Knockout on Endothelium-dependent and -independent Relaxation of Mouse Arteries
… relaxation (EDR) of vascular smooth muscle in resistance-type arteries. Further, we found that treatment of mesenteric arteries with inhibitors of cyclooxygenase and nitric oxide synthase combined, restored normalized acetylcholine-induced EDR in EC PAR2-/- mice. Therefore, reduced EDR in EC …
-
CaV3.2 Channels and BKCa-Mediated Feedback in Vascular Smooth Muscle
… from individual smooth muscle cells to whole arteries, and which entail the use of patch clamp electrophysiology, Ca2+ imaging, pressure myography, immunohistochemistry, quantitative polymerase chain reaction (qPCR) and computational modeling. In initial work, perforated patch …
-
Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle
Resistance arteries are a major point of physiological regulation of blood flow. Increases in vessel wall stress or sympathetic activity stimulate vascular wall angiotensin signaling, resulting in smooth muscle contraction which directly increases peripheral resistance. Calcium influx through …
-
Integration of signalling in smooth muscle caveolae
… C-mediated arterial contraction was increased. Arteries lacking caveolae weighed more per unit length, suggesting growth of the arterial wall. I go on to demonstrate that small resistance arteries from KO mice are remodelled, and that these and other changes counterbalance an excessive NO …
-
Heterogeneity in the vascular endothelium enables parallel processing of multiple stimuli
… from hundreds of endothelial cells in intact resistance arteries. The results show that the endothelium is not a homogenous population of cells. Instead, spatially-distinct endothelial cells are primed to detect specific extracellular signals. These spatially distinct cells are arranged in …
-
Cerebral Microcirculatory Effects of Maturation
… of newborn and adult sheep middle cerebral arteries, 5-HT2 serotonergic receptors mediate contractile responses to serotonin and that alpha-1 adrenergic receptors mediate contractile responses to norepinephrine. In addition, tissue sensitivity to 5-HT and NE decreases significantly with …
-
Effects of a Pharmacological Activator of Ca2+-activated K+ Channels (KCa2/3) on Recovery from Acute Myocardial Infarction in Mice
… improved agonist-evoked vasodilation in resistance arteries from multiple vascular beds and species, and this effect remains robust in arteries from Type 2 Diabetic tissues. Prolonged administration of SKA-31 to aged male rats also improved both their cardiac and vascular functions. In my …
-
DHA-rich fish oil and regular moderate exercise: a combined intervention to improve cardiovascular, metabolic and inflammatory biomarkers in obesity.
… although it improved the compliance of small resistance arteries. Interestingly, however, both DHA-rich fish oil and regular exercise reduced body fat and these effects were additive when the interventions were combined. The change in fat mass was accompanied by an increase in fat oxidation …
-
Comparing glutathione peroxidase and glutathione reductase activity and their associations with cardiovascular measures in Africans and Caucasians : the SABPA study
… including changes in vascular tone of resistance arteries and vascular remodelling. The endogenous antioxidant enzymes glutathione peroxidase and glutathione reductase work synergistically to maintain intracellular redox balance. Both these enzymes have been indicated to have varying …
-
Characterisation of the pharmacological actions in humans of multiple vasoactive enzyme inhibitors with therapeutic potential in heart failure
… with chronic heart failure. Methods 1) Small resistance arteries from patients (n=89) with coronary artery disease but normal left ventricular function were studied using wire myography. The vasopressor response to various neurohormones in the presence of omapatrilat, KC12615 (the active …