Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"residual structure"”.
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Observing residual structure in disordered peptides with multidimensional infrared spectroscopy
… of NMR or ESR, little is known about their structure or function. By combining isotope-edited two-dimensional infrared spectroscopy (2D IR) with spectral modeling based on molecular dynamics simulations, this work will show that one can measure the residual structure and conformational …
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THERMODYNAMIC AND KINETIC PROPERTIES OF CYTOCHROMES C AND C’ IN THE DENATURED STATE: PROPENSITY FOR RESIDUAL STRUCTURE
… our understanding of helical propensity and residual structure in the denatured state, two approaches have been taken. In the first project, we have engineered serine in place of alanine near the center of the third helix (positions 83 and 87) in cytochrome c’ (Cytc’) and have measured …
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THERMODYNAMIC AND KINETIC PROPERTIES OF CYTOCHROMES C AND C’ IN THE DENATURED STATE: PROPENSITY FOR RESIDUAL STRUCTURE
… our understanding of helical propensity and residual structure in the denatured state, two approaches have been taken. In the first project, we have engineered serine in place of alanine near the center of the third helix (positions 83 and 87) in cytochrome c’ (Cytc’) and have measured …
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Computational studies of tau protein : implications for the pathogenesis and treatment of neurodegenerative diseases
… evidence exists that such proteins may exhibit residual structural preferences. In this work, models of tau are constructed to characterize these structural preferences. We begin by performing molecular dynamics simulations to study the inherent conformational preferences of the minimal tau …
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Investigation of the interaction of GdnHCl with poly-L-lysine, horseradish peroxidase and cytochrome c monitored via FTIR, CD and fluorescence spectroscopies
… the interaction between Gdn-d 5 -DCl and random structures. Spectroscopic evidence strongly suggested that Gdnd 5 -DCl associates with PLL, particularly with its lysyl side chains. The analysis of HRP indicated that it was not a suitable model due to complex time-dependent spectral changes. The …
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Investigation of the kinetics of protein folding and the ensemble of conformations in non-native states of proteins by liquid NMR spectroscopy
… description of protein folding dynamics and the structure of the folded state, of unfolded and of non-native states of proteins and the kinetics of protein folding from the unfolded state to the folded state have to be determined. The focus of this PhD thesis was the development of novel NMR …
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On the Kinetics of Protein Misfolding and Aggregation
… (mis)folding into highly ordered, fibrillar structures, amyloid fibrils, is a hallmark of several, mainly neurodegenerative, disorders. The mechanism of this supra-molecular self-assembly reaction, as well as its relationship to protein folding are not well understood. In particular, the …
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Thermodynamics and Kinetics of Iso-1-cytochrome c Denatured State
… must involve the formation of the most primitive structure possible – a simple loop. Our laboratory has developed a system of studying simple loops in the denatured state using c-type cytochromes. New insights into how the properties of these loops impact the denatured state are outlined in this …
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Thermodynamics and Kinetics of Iso-1-cytochrome c Denatured State
… must involve the formation of the most primitive structure possible – a simple loop. Our laboratory has developed a system of studying simple loops in the denatured state using c-type cytochromes. New insights into how the properties of these loops impact the denatured state are outlined in this …
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Functional Relevance of Protein Disorder: Why is Disorder Favourable?
… grounded on the idea that the three-dimensional structure of a protein underlies its function. However, increasing evidence of natively unstructured but functional proteins is accumulating. Termed as intrinsically disordered proteins (IDPs), they populate a number of different conformations in …
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Structural and biochemical studies of the yeast linker histone, Hho1p
… species: folded and “unfolded”. In Chapter 2 the structure of the second globular domain of Hho1p, GII, is further investigated. NMR studies indicate residual structure in the “unfolded” form of GII, especially at the start of helices I and III. Chapter 3 considers the structural roles of Hho1p …
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Quantifying the Impact of Pavement Surface Properties on Road Safety: A Data-Driven Approach
… ratios (IRR) with 95% confidence intervals, and residual structure was screened using cumulative residual (CURE) plots alongside a simple multicollinearity check. Across 14 functional classes, the extended model outperformed the base in 12 classes, indicated by the difference in AIC median = …