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Showing 1 to 6 of 6 for “"residual dipolar couplings"”.
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Dynafold: A Dynamic Programming Approach to Protein Structure Calculation From Residual Dipolar Couplings
… crystallography. A new type of NMR restraint, residual dipolar couplings (RDCs), has shown promise as a source of data for large classes of proteins including transmembrane proteins.</p> <p>To date, most methods of utilizing residual dipolar couplings as structural re- straints have centered …
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NMR application and development : study of the ribosomal RNA-L11 complex
… number of orientational restraints derived from residual dipolar couplings in addition to conventional NOE-based restraints. The solution structure of L11 demonstrates that in contrast to many other multi-domain RNA- binding proteins, the relative orientation of the two domains is well defined as …
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Determination of Biomolecular Interdomain Motions using Nuclear Magnetic Resonance
… of interdomain orientations, we measured residual dipolar couplings (RDCs) from the two domains with multiple alignments. The N-terminal domain was directly aligned by a lanthanide ion and not influenced by interdomain motions, so it acted as a reference frame to achieve motional …
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Structure determination of proteins and peptides in solution: simulation, chirality and NMR studies
… from a protein. In this context, the effect of Residual Dipolar Couplings (RDCs) in the structure refinement was shown, revealing a strong improvement of structure resolution. A wide extent of this thesis is devoted to the study of avian prion protein. Prion protein is the main responsible of a …
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Building Better Backbones: Visualizations, Analyses, and Tools for Higher Quality Macromolecular Structure Models
… for calculating core protein models from NMR residual dipolar coupling (RDC) data. Third, I describe how 3D visualization of RDCs in their structural context improves understanding of RDCs and validates NMR models in a novel way. Fourth, I describe how local quality analysis can diagnose …