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Showing 1 to 15 of 15 for “"reserpine"”.
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Effects of Reserpine (Serpasil) on Bloat
… or sedation. Of all the tranquilizers studied, reserpine has been most extensively studied in the laboratory and in clinical use. Tranquilizers work on the primitive parts of the brain, especially the hypothalamus and the reticular formation. These areas govern the basic life functions normally …
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A study of the effects of oxypertine on monoaminergic pathways in rat brain using a new HPLC/ECD method.
… the action of oxypertine against the action of reserpine has shown a difference between the two compounds. Reserpine causes at least 90% reduction in neuronal amine content while oxypertine caused no reduction in neuronal amine content. These results combined with the results of behavoural …
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Targeted Drug Discovery: Targeting a Specific Conformation of MutS/MSH Proteins with Small Molecules
… bind the "death" conformation of MSH2/MSH6. Reserpine and its derivative rescinnamine were identified, both compounds previously used in the treatment of hypertension. Reserpine and rescinnamine decrease cell viability and activate caspase 3 cleavage in a MSH2- and MSH6-dependent manner. In …
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The Neurotoxicity of Insecticides to Striatal Dopaminergic Pathway
… studies on the mode of action of rotenone-/reserpine-/tetrabenzaine (TBZ)-induced depletion, in vitro, as these three compounds share some similarities in their chemical structures. I found that rotenone, reserpine and TBZ selectively released preloaded dopamine and serotonin (5-HT), with …
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Using prophylactics to improve resistance against Enterobacteriaceae in chickens
… live Salmonella vaccine, ileal spores, or reserpine) could mitigate Enterobacteriaceae activities in poultry.In the first study of this thesis, we explored whether the combinatorial use of a commercial probiotic mix (Gro-2-Max®) and live Salmonella vaccine (Typhimurium strain) in white …
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Altered Autonomic Nervous System Function in Chickens Divergently Selected for Body Weight
… of HWS and LWS chickens to ip injections of reserpine were compared. Reserpine caused a transitory decrease in food intake and body weight in both lines of birds. However HWS chickens recovered more slowly from the depression caused by reserpine than the LWS chickens. This could be due to …
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Analysis of the behavioural effects of barley and sertraline in two in-vivo models of stress.Anti-depressant and anti-nociceptive effects of barley in mice and sertraline effects on anxiety in the offspring of prenatally-stressed rats
… the depressive-behaviour in mice induced by the Reserpine Test (n=114, 58 reserpinised, 56 non-reserpinised) and Social ‘Defeat’ Test (n=24, 8 vehicle undefeated, 8 barley defeated, 8 vehicle defeated mice). To confirm that the anti-depressant effects of barley(6.4g/kg) were not simply due to …
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Genomic and Physiological Differences for Ghrelin and Leptin Receptor in Lines of Chickens Selected for High and Low Body Weight
… body weight (LWS). Intraperitoneal injections of reserpine were administrated to chickens from the HWS and LWS lines. Body weight and food intake were then compared to evaluate ANS regulation. While reserpine caused a transitory decrease in food intake and body weight in both lines, the magnitude …
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The Role of Connexin36 in Dopamine D1/D2 Synergism and its Breakdown in Transgenic Mice
… leads to resistance to the cataleptic effects of reserpine in a gene dosage-dependent manner.
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FUNCTIONAL AND BIOCHEMICAL CONSEQUENCES OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE HUMAN VESICULAR MONOAMINE TRANSPORTER 1 GENE (SLC18A1) By Sally Gamal Shukry, B.S.
… Response of the 4Pro/Ser98 to the VMAT inhibitor reserpine was lower than that of the 4Thr/98Thr. These findings suggest mechanisms for human VMAT1 links to schizophrenia.
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The Role of Escherichia Coli Endotoxins in The Pathogenesis of Lactation Failure in The Sow
… that the dopamine vesicle depleting agent, reserpine (0.025 mg/kg), and the DA receptor blocking agents, haloperidol (10 mg/sow) and chlorpromazine (0.5 mg/kg), were ineffective in elevating PRL concentrations when given on PP + 5 or PP + 6. TRH (500 (mu)g IM) elevated PRL for 20-30 minutes. …
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Essential Function of Ghrelin in Chronic Starvation
… antagonist. Treating WT mice with atenolol or reserpine, a drug that depletes adrenergic neurotransmitters from sympathetic neurons, blocked the fasting-induced increase in plasma ghrelin. Thus, ghrelin secretion during fasting is induced by adrenergic agents released by sympathetic neurons …
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A Modular Approach to Highly Functionalized Indole Derivatives and Syntheses of Tryptamine-based SHIP Inhibitors
… useful natural products like ergotamine, reserpine, vincristine. Indole alkaloids have been fascinating chemists and biologists alike because of its diverse biological activity and intrinsic structural complexity. N-alkylated tryptamines, along with their analogs, are recognized as potent …
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On the functional role of serotonin in the mammalian central nervous system
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).