Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 368 for “"resection"”.
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The circadian Control of DNA end Resection
… the circadian clock in the regulation of DNA end resection, the licensing step of HDR. Thus, we demonstrated that the circadian factor CRY1 drives circadian oscillations in DNA end resection, which results in circadian fluctuations in HDR. Mechanistically, we show how this protein is recruited to …
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The metabolic sequelae of oesophago-gastric resection
Bypass or resection of the stomach and oesophagus, has long been recognised to result in profound changes in the handling of ingested nutrients. This results in significant morbidity after radical surgery for oesophago-gastric cancer, in particular post-prandial hypoglycaemia, altered appetite, …
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Crosstalk between DNA end resection and RNA metabolism
DNA suffers thousands of lesions from exogenous and endogenous sources. Nevertheless, double-strand breaks (DSBs) are the most dangerous form of DNA damage because if they are not properly repaired they can lead to mutations and genomic instability. In order to repair them, cells have developed two …
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53BP1/Shieldin Counteract DSB Resection Through Fill-In Synthesis
… at DSBs by recruiting CST/Polα to counteract resection, challenging the long-standing model of a block to resection by this pathway. Like loss of 53BP1/RIF1/shieldin, disruption of CST/Polα/primase reverses the hallmarks of BRCA1- deficiency. CST/Polα localize to DSBs, and we directly detect …
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Novel imaging biomarkers and resection strategies in pancreatic cancer
Contains fulltext : 312719.pdf (Publisher’s version ) (Open Access)
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Bi-functional scaffold for bone regeneration after osteosarcoma resection
L'abstract è presente nell'allegato / the abstract is in the attachment
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Analysis of factors influencing early outcome following liver resection
… morbidity and mortality following liver resection. A secondary aim was to analyse the outcome of liver resection for colorectal liver metastases (CRLM) to identify factors associated with tumour recurrence and survival. Methods A retrospective review of a prospectively maintained database …
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Enhancing recovery in non-critical care emergency bowel resection
… (Level 0/1) patients following emergency bowel resection.<br/><br/>Method: A single centre comparative observational study was used to compare outcomes between two existing parallel groups of Level 0/1 emergency bowel resection patients. Strict inclusion criteria governed eligibility. Groups …
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INJECTABLE HYBRID HYDROGELS FOR LOCAL CHEMOTHERAPY OR TUMOR-SPECIFIC RESECTION
The aim of my thesis is to develop cutting-edge and innovative delivery system able to encapsulate active molecules against cancer. The purpose is to have a material that can target directly the tumoral environment, avoiding the toxicity to surrounded organs and enhancing the local pharmacological …
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Devising an Algorithm for Resection Amount in Conjunctiva Sparing Ptosis Surgery
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The role of biofeedback in improving anal continence after anterior resection
… with rectal cancer who are undergoing anterior resection offers potential for improved anal continence compared with standard management. A multicentre randomised controlled trial was performed to investigate this and 121 participants undergoing major rectal resection were randomly assigned to …
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Collagen scaffolds in full- and hemi- resection spinal cord injury models
… select therapeutic agents in both fulland hemi- resection injury models in adult rats. In the hemi-resection injury model, the treatment groups included: a dehydrothermally (DHT) crosslinked scaffold, a carbodiimide (EDAC) crosslinked scaffold, and an EDAC-treated scaffold delivering either …
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An Optical Resection Local Positioning System for an Autonomous Agriculture Vehicle
… tasks that involve multiple vehicles. Optical resection is proposed as a potentially more cost-effective and scalable positioning system for such cases. The proposed system involves the placement of optical beacons at known locations throughout the environment and the use of cameras on the …
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Endoscopic Resection and Post-Operative Brachytherapy in the Treatment of Sinonasal Melanoma
… but therapy remains controversial. Complete resection is a surgical challenge and it is often impossible to achieve adequate margins due to the fact that tumour often abuts vital anatomical structures. Incomplete resection has been shown to be a predictor of poor survival. Harris et al. …
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Pre-operative Functional Magnetic Resonance Imaging: Application to Tumour Resection by Awake Craniotomy
… with the surgeon attempting to maximize tumour resection while simultaneously sparing healthy cortex. Pre-operative and intra-operative brain mapping techniques are capable of localizing eloquent cortex, and are thus employed to facilitate the surgical decisions. Although direct cortical …
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Three Dimensional CT based Virtual Patellar Resection in Female Patients undergoing Total Knee Replacement
… influenced by the accuracy of the patellar resection, with the resultant thickness and symmetry of the patella-implant composite Methods: We performed virtual patellar resection with digital software using 3D-CT scans of knees from 49 patients who underwent primary TKR at our hospital, …
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Expression of Survivin : Possible Predictor of Local Recurrence after Curative Resection for Rectal Cancer
Local recurrence has always been a challenging problem following rectal cancer surgery, desite of the advances in surgical technique(TME) as well as adjuvant therapy(preoperative CCRT). There is a need for better prognostic markers due to the varieties of treatment response within same …
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Clinical and Pathologic Characteristics of Hepatocellular Carcinoma following Resection according to the Tumor Size
… known to be an important prognostic factor after resection and it is considered to be closely correlated with vascular invasion of HCC. We aimed this study to elucidate the outcomes according to some previously studied size criteria and the relationship between the size criteria and …
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Liver resection for hepatocellular and fibrolamellar carcinoma in a South African tertiary referral centre
… curative treatment for early-stage HCC includes resection, transplantation and ablation. Surgical resection is the treatment of choice in patients without cirrhosis and in those with cirrhosis and well-preserved hepatic function. Despite advances in surgical techniques and perioperative care, …
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