Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 239 for “"repurposing"”.
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Drug Repurposing Using Gene Expression Data Mining
… been used to treat some medical conditions. Drug repurposing is considered a promising method due to its accelerated the process of drug discovery and lower overall cost and risk.</p> <p>Drug-perturbed gene expression profiles are powerful phenotype readouts of biological systems, and they have …
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Media streams--representing video for retrieval and repurposing
Thesis (Ph. D.)--Massachusetts Institute of Technology, Program in Media Arts & Sciences, 1995.
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Drug Repurposing for COVID-19 Using Molecular Docking Tools
… finding a treatment is time critical. Drug repurposing is probably the quickest and safest approach in our arsenal. However, testing every drug in a brute force manner would require a lot of resources, and a more sophisticated method is required to filter possible candidates. Since several …
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Underground agriculture: repurposing abandoned tunnels in coal-mining systems
The student, Qingyi Zhao, accepted the attached license on 2016-06-27 at 16:27.
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Repurposing chlorpromazine and its metabolites for antituberculosis drug discovery
New chemotherapeutics are urgently needed to combat Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). The development of compounds that could potentiate the activity of known antimycobacterial drugs is a relatively unexplored approach to new TB drug discovery. This study …
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Repurposing Colonialism: Postcoloniality and the Politics of World Heritage
Since the turn of the 21st century, countries in the Global South have increasingly sought to inscribe their heritage sites on UNESCO’s World Heritage List. World Heritage listing is considered prestigious because it brings global recognition, secures political legitimacy, boosts tourism, and …
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Content repurposing of electrical diagrams for presentation in handheld devices
This thesis proposes a design for content repurposing of electrical diagrams for presentation in small-screen wireless handheld devices. Content repurposing is the on-line adaptation of content to fit device capabilities and user's preferences. The focus of this thesis is on electrical diagrams of …
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Reconstructing Visual Appearance and Process by Repurposing Pretrained Diffusion Models
… tasks under partial observation? I explore repurposing strategies across different supervision regimes. In settings where paired training data is unavailable, I develop methods that exploit weakly aligned observations or synthetically constructed supervision to enable appearance …
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Repurposing a Roomba: Evaluating and training behavior in a simple agent
Recent attempts to reprogram a Roomba to be used as a simple agent have led to interesting behavior. Observation has shown that the behavior of the Roomba is not only dependent on the precepts of the Roomba, but also relies heavily on the uncontrollable environmental conditions that the Roomba is …
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OPTIMIZING RAIL NETWORK TOPOLOGY ATTRIBUTES FOR TRACK RECLASSING, ACQUISITION AND REPURPOSING
… enhancement is often done by reclassing or repurposing existing rails or acquiring new rails. This thesis focuses on optimizing the topology of a network and proposes a methodology to optimize its efficiency using track reclassing, acquisition, and repurposing as means for topological …
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Repurposing Antibacterial Compounds and Natural Products to Combat Vancomycin-Resistant Enterococci
… challenge: natural product discovery and drug repurposing. The first study investigated two drug candidates, CRS3123 and ridinilazole, originally designed to target Clostridioides difficile, for their activity against VRE. Both compounds showed exceptionally low minimum inhibitory …
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Broad-spectrum antivirals against coronavirus using natural products and drug repurposing strategies
… product-based discovery and host-targeted drug repurposing. Chapter three investigates natural product-based antiviral discovery, with a focus on Nigella sativa (black seed) oils. While direct contact assays revealed limited antiviral efficacy, vapour-phase diffusion of the oils significantly …
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Repurposing itraconazole as a novel and promising therapeutic strategy for pancreatic cancer
… affect clinical outcomes and quality of life. Repurposing drugs offers a rational, evidence-based approach which can provide sustainable access to cost-effective therapeutic options for cancer. Accordingly, this thesis has examined repurposing itraconazole, which is an inexpensive and …
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Rational Identification of Neuropilin-1 Inhibitors: From Deep-Learning to Drug Repurposing
… deep-learning-guided peptide identification and repurposing-oriented screening with validation and disease-context mapping. With this ‘proof-of-concept’ study, the work provides a basis for subsequent optimisation and for translation of NRP1-targeted inhibitors toward therapeutic development.
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Repurposing non-antimicrobial drugs to treat multi-drug resistant bacterial and fungal infections
<p>Bacterial and fungal resistance to conventional antimicrobials is a burgeoning global health epidemic that necessitates urgent action. Even more alarming, the development of new antimicrobials to treat these multidrug-resistant pathogens has not kept pace with the rapid emergence of resistance …
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Lessons Learned in Project Management of Repurposing an Obsolete Facility for Today's Use.
… They will be converted to their safest form. The repurposing of the facility was not a simple undertaking as all of the utilities with the exception of electricity were disconnected from the facility and the furnaces were more than 50 years old. A 2-part project consisting of a construction phase …
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Repurposing variance genome-wide association studies (vGWAS) for identifying gene-by-environment interactions
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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The Potential for Repurposing Disturbed Mining Properties in Nevada as Utility-Scale Solar Facilities
… mine that may be ideal for utility-scale solar repurposing while also projecting a positive Return on Investment for 28 potential sites in the Carlin Trend mining region. This thesis intends to provide a useful perspective for potential solar developers regarding the repurposing of disturbed …
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