Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 364 for “"reprogramming"”.
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Cellular reprogramming
DNA-methylatie is een epigenetische modificatie. Dit type van modificaties verandert de genetische informatie zelf niet, maar wijzigt de laag erboven. Er worden chemische modificaties toegevoegd of gewijzigd op het DNA of de histonen (waarrond het DNA gewonden is). DNA-methylatie is die modificatie …
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Reprogramming the Suburbs
Housing shortages have plagued many large North American cities and urban areas over the last several decades. In many such regions, less affluent areas are rapidly redeveloped and densified to keep up with housing demand. This frenetic development displaces lower income residents and tears apart …
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Cellular reprogramming in eukaryotes
… In the first half, we will look into reprogramming via the introduction of external network components such as an artificial transcription factor (gene switch) or a pathway. In one example, we report the development of a gene switch that is able to regulate the endogenous VEGF-A …
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Modularity in Somatic Cell Reprogramming
Reprogramming relies on the concept that cellular fate is plastic, and therefore a considerable effort has been made to develop molecular strategies that reset the epigenome to achieve distinct cell fates, including stem cells. Deriving induced pluripotent stem (iPS) cells has thus emerged as a …
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Programming and reprogramming cellular identity
… and autoimmunity, and suggest a strategy for reprogramming based on chemical manipulation of the cellular programs that control cell identity.
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REPROGRAMMING LUNG FIBROBLASTS INTO LUNG PROGENITORS
… that can reverse fibrosis once it has occurred. Reprogramming technology provides exciting avenues for treatment of disease. Direct reprogramming involves the conversion of one cell type directly into another; fibroblasts have been reprogrammed into neural, cardiac and hepatic lineages using …
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Novel Regulators of Somatic Cell Reprogramming
… focused on exploring the mechanisms underlying reprogramming using a secondary mouse embryonic fibroblast model that forms iPS cells with high efficiency upon inducible expression of Oct4, Klf4, c-Myc and Sox2. My analyses of the temporal changes in gene expression reveal that reprogramming is a …
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Molecular Regulation of Direct Cardiac Reprogramming
… and form scar tissue following heart injury. Reprogramming CFs to induced-cardiomyocytes (iCMs) by forced expression of cardiac specific transcription factors holds promise for enhancing cardiac repair by reducing scar tissue while simultaneously generating new cardiomyocytes. However, low …
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Recording and Reprogramming Neuroimmunity in Cancer
Adult and pediatric glioblastomas are incurable and universally lethal, with a median survival under 15 months. Despite this overwhelming unmet medical need, therapies developed over the last three decades have been unable to extend patient lifetime beyond a few months. These therapies, which …
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Reprogramming cellular fate using defined factors
… pluripotent stem cells from patients. Nuclear reprogramming offers the possibility of creating patient-specific cell lines, thus abrogating the need for immunosuppressants following cell transplantation therapy. It was recently reported that the forced expression of four transcription factors, …
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Reprogramming to Pluripotency Using Small Molecule Compounds
… compounds has evolved as a potential cellular reprogramming strategy. Individually, specific small molecule compounds have previously been shown to replace reprogramming transcription factors or enhance the efficiency of cellular reprogramming. More recently, a combination of small molecule …
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DIRECT REPROGRAMMING OF HUMAN FIBROBLASTS INTO CARDIOMYOCYTES
Direct reprogramming of human fibroblasts into induced cardiomyocytes (iCMs) offers a potential therapeutic approach for cardiovascular disease yet hampered by low efficiency of human iCM generation. Here, we established an optimal culture condition by defining a chemically defined media (CDM). In …
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Modeling Alzheimer's Disease Using Cellular Reprogramming Technologies
Two cellular reprogramming technologies have emerged that demonstrate that cell-fate can be converted by ectopic expression of defined transcription factors: induced pluripotent stem (iPS) cell technology and induced neuronal (iN) cell technology. These recent advances in cell reprogramming …
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Frameworks for reprogramming early diverging land plants
… the development of engineering frameworks for reprogramming of the early diverging land plant Marchantia polymorpha (Marchantia). I describe the generation of genomic and transcriptomic datasets for Marchantia, which has provided the basis for the compilation of a gene-centric registry of DNA …
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Modelling Huntington’s Disease Using Direct Cell Reprogramming
… of generating a representative model of HD. Cell reprogramming is a revolutionary technology that can generate live, human neurons in vitro from the somatic cells of individuals with HD. Our research group was the first to demonstrate the direct reprogramming of adult human dermal fibroblasts …
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Oncogene-induced reprogramming of heterotypic cellular interactions
KRAS is a critical signalling hub that orchestrates fundamental cellular decisions such as cell survival, proliferation and differentiation. Activating mutations in KRAS are among the most frequently occurring oncogenic mutations driving cancers that are particularly refractory to therapy (e.g., …
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Rejuvenation of CNS Progenitors via Partial Reprogramming
Adult stem cells become less efficient at maintaining tissue integrity and repairing tissue damage with age. Oligodendrocyte progenitor cells (OPCs) are the largest population of stem cells in the adult CNS and give rise to oligodendrocytes. OPCs play a critical role in myelin regeneration …
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Induced pluripotency and reprogramming by defined factors
… However the molecular mechanisms of somatic cell reprogramming have remained largely a mystery. Recent advancements in epigenetic reprogramming by defined factors provide new opportunities to explore factors that regulate induction of pluripotency in somatic cells. Nuclear reprogramming by SCNT …
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REGULATION OF TELOMERASE EXPRESSION IN STEM CELL REPROGRAMMING
A great need exists for an abundant, easily accessible source of patient-specific cells that will function for use in regenerative medicine. One promising source is the adult stem cell derived from adipose tissue (ASCs). Isolated from waste lipoaspiration, these cells could serve as a readily …
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Molecular Mechanisms of Metabolic Reprogramming in Pancreatic Cancer
… This suggested role of PKD1 in metabolic reprogramming in pancreatic cancer. Also, we observed that PKD1 stimulates the glucose uptake through mTORC1, a component of mTOR signaling pathway. Additionally, the knockdown of PKD1 promoted the chemosensitivity of cells towards gemcitabine and …
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