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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"repressors"”.
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Differential responsiveness of repressors and sensitizers to stress
Repressors and sensitizers were subjected to either electric shock or failure instructions in a verbal learning situation. Heart rate, skin conductance, and state anxiety data were obtained for a 10-min anticipatory period prior to learning as well as for the learning period itself. Results showed …
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In vivo studies of repressors of RNA polymerase III transcription
… work in this thesis focused on the role of these repressors in regulating Pol III transcription in human cells.
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The role of the leukemia-associated ETO homologue repressors in hematopoiesis
… ETO, all these proteins being transcriptional co-repressors present in complexes together with other co-repressors such as SIN3, N-CoR and SMRT, and histone deacetylases. The objective of this thesis was to investigate the role of the ETO-homologues in hematopoiesis and leukemia. First, the …
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Receiver-Operating Characteristics of Repressors and Sensitizers During Word Recognition Performance
Made available in DSpace on 2014-12-08T23:01:27Z (GMT). No. of bitstreams: 1 6604314.pdf: 1786468 bytes, checksum: a21540343b79055263670f4550d7f305 (MD5) Previous issue date: 1965
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Locus-specific proteomics identifies novel repressors of Epstein-Barr virus reactivation
… DNA. My PICh experiment identified two new EBV repressors: the polycomb complex PRC1 and the nucleosome remodeler CHD4. These proteins were found to independently bind the latent EBV genome and CRISPR-Cas9-mediated depletion of either of these components resulted in spontaneous lytic …
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Transcription Coupled DNA Repair in Saccharomyces Cerevisiae: the Interplay of Facilitators and Repressors
… This dissertation focused on how the TCR repressors and facilitators interplay with RNA polymerase II (RNAP II) to carry out TCR in yeast Saccharomyces cerevisiae. By site-specific incorporation of the unnatural amino acid p-benzoyl-L-phenylalanine, we mapped interactions between Spt5 and …
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C. Elegans OMA-1 and OMA-2 are Transcriptional and Translational Repressors of Germline Fate
… converts OMA proteins from oocyte translational repressors to embryonic transcriptional repressors. Phosphorylated OMA proteins can interact with TAF-4 in the newly fertilized C. elegans embryos and repress global transcription to prevent premature somatic differentiation during early stages of …
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Untersuchungen zur Assoziation des transkriptionellen Repressors Snail aus Drosophila melanogaster mit den Korepressoren CtBP und HDAC1
… Rahmen dieser Arbeit wurde die Interaktion des Repressors Snail mit HDAC-Aktivität funktional charakterisiert. Mit Hilfe von Kopräzipitationsexperimenten unter Verwendung von rekombinantem Snail und embryonalem Drosophila Kernextrakt konnte die Assoziation von Snail mit CtBP oder HDAC1 gezeigt …
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Characterization of NfxB and PA4596, Two Repressors of the mexCD-oprJ Operon Encoding an RND-Type Multidrug Efflux Pump in Pseudomonas aeruginosa
MexCD-OprJ is an RND-type multidrug efflux pump present in P. aeruginosa and is capable of exporting, and as such providing resistance to, several clinically important antimicrobials including fluoroquinolones, cephems, macrolides, and several biocides including chlorhexidine (CHX). Expression of …
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Repressors vs. Low- and High-Anxious Coping Styles: EEG, Heart Rate, and Blood Pressure Differences During Cognitive and Cold Pressor Pain Stressors
Repressors, defined as individuals possessing an increased cortical sensitivity to anxiety-provoking stimuli combined with the tendency to avoid such stimuli, may be differentiated from low- and high-anxious individuals. This study investigated behavioral performance, electrophysiological …
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The Rating of Sexual and Nonsexual Cartoons as a Function of Repression-Sensitization
… of Marlowe-Crowne Social Desirability scores, repressors were differentiated into defensive and nondefensive.</p> <p>The independent variable involved the presentation of two types of cartoons: sexual and nonsexual.</p> <p>The two dependent variables were: the proportion of sexual versus …
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Age and Responses to the Events of September 11, 2001
… time one and two. For young adults, high hardy repressors faired best, followed by high hardy sensitizers. Low hardy young adults demonstrated similar levels of dysfunction regardless of coping style (repressions/sensitization). For older adults, coping style impacted both high and low hardy …
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Pioneer Factors Compete for Epigenetic Factors in Switching Stem Cell Fates
… can either act as transcriptional activators or repressors of cell fates by recruiting co-activators or co-repressors. Nevertheless, whether and how a single factor can simultaneously silence the old fate while activating the new cell fate remains largely unknown. Here, I tackled this question …
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Regulation of the mobile genetic element ICEBs1 by a conserved repressor and anti-repressor
… ImmR is similar to many characterized phage repressors, we found that, unlike these repressors, inactivation of ImmR requires an ICEBslencoded anti-repressor ImmA (YdcM). Under ICEBsl-inducing conditions, ImmA cleaves ImmR at a specific site to induce the element. We found that changing the …
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Caracterización funcional de Snail2 como represor de cadherina- E y como regulador del proceso de carcinogenésis química
… has been identified different transcriptional repressors of E-cadherin gene, which in turn induce TEM, including factors the zinc finger family of Snail (Snail1 and Snail2) and ZEB (ZEB - 1 and ZEB-2) and factors of the bHLH family (E47 and Twist). Previous studies of our laboratory, comparing …
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Studies on the operator-repressor-effector interactions in the glp regulon of Escherichia Coli K-12
… for repressor binding. Cooperative binding of repressors to tandem operators was demonstrated. Cooperativity was maximal when two 20-base pair operators were directly repeated and decreased with the deletion of 2 base pairs or the addition of 4 base pairs between the operators. Cooperative …
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Precise Temporal Regulation of Ribonucleoprotein Complexes during the Drosophila Maternal-to-Zygotic Transition
… RBP forms ribonucleoprotein complexes with corepressors, Trailer hitch (TRAL), Maternal expression at 31B (ME31B) and Cup, as well as AGO1 and the CCR4-NOT deadenylase to regulate the translation and stability of hundreds of maternal mRNAs, and this regulation is required for proper …
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Regulation of proliferation, apoptosis, and metastasis in prostate cancer cells by DAX-1 (NR0B1)- an androgen-induced orphan nuclear receptor
… Nuclear Receptors (NRs) and transcriptional co-repressors and co-activators. While DAX-1 plays an important role in adrenal and gonadal development, recent studies have elucidated the role DAX-1 plays as a transcriptional repressor and its influence on the progression of different types of …
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Characterization of the repressor from the lambdoid phage HK022.
… to either mode is controlled by the cI and Cro repressors which bind to operators in the λ chromosome and regulate gene expression of adjacent promoters. HK022 is organized similar to λ, but has its own unique repressors and operators which are different from λ. The major goal of this research …
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Biomolecular and computational frameworks for genetic circuit design
… design. In this thesis, we explore TetR-family repressors and the CRISPRi system as candidates. First, we applied 'part mining' to build a library of TetR-family repressors gleaned from prokaryotic genomes. A subset were used to build synthetic 'NOT gates' for use in genetic circuits. Second, we …
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