Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 132 for “"repressing"”.
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P107 negatively regulates the neural precursor pool by repressing Hes1 transcription
Stem cells are defined by their multipotentiality and their long-term ability to self-renew. P107, a member of the pocket protein family of cell cycle regulators has previously been shown in our laboratory to negatively regulate neural precursor cell number and self-renewal (Vanderluit et al., …
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Repressing the future: Relationships between reconstructions of the past and construction of the future.
Repressing the future: Relationships between reconstructions of the past and construction of the future.
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An investigation of the role of CreB deubiquitinating enzyme in the regulation of carbon metabolism in Aspergillus nidulans
… repressor protein CreA which, in the presence of repressing carbon sources, represses those genes that are required to utilize less preferable carbon sources. Mutational analyses suggested that ubiquitination, mediated by CreD together with ubiquitin ligase HulA, and deubiquitination, mediated by …
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Distribution of proteins involved in carbon catabolite repression in Aspergillus nidulans.
… CreA, CreB, CreC and CreD in A. nidulans in repressing and derepressing conditions. The major regulatory protein involved in CCR in A. nidulans is CreA. It is a DNA-binding repressor, but very little is known about the molecular events that allow CreA function to result in appropriate …
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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
… can modulate apoptosis in leukemic cells by repressing MCL-1 and increasing their responsiveness to BH3-mimetics. This signaling pathway could represent a generalizable mechanism for repressing MCL-1 expression in malignant cells and sensitizing them to available therapeutics.</p>
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… the follicular helper (Tfh) lineage while repressing Th1, Th2 and Th17 differentiation. Bcl6-deficient mice develop a spontaneous and severe Th2-type inflammatory disease including myocarditis and pulmonary vasculitis, suggesting a potential role for Bcl6 in Treg cell function. …
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The Estrogen Response Element and the KRAB Repression Domain as Modulators of Estrogen Receptor Action
Repressing expression of estrogen regulated genes would greatly facilitate studies of their function. Therefore we transformed ER into a transcription repressor by fusing the KRAB transcription repressor domain of the Kox1 protein to ER and various ER mutants. Incorporation of DBD mutations …
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Citizens Electoral Behavior in Autocratic Regimes, Venezuela, Turkey, Russia
… liberties to turning to violence as a method of repressing dissidence yet voters continue to vote them back into power. Why? Through an examination of the current situations in Venezuela, Turkey and Russia, the thesis reveals that economic performance provides the key explanation. If the country …
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Mechanism of Human Papillomavirus E6-Mediated Repression of P53-Target Gene *Transcription
… protein complex is critical for repressing p53-target gene activation. It is likely that this mechanism for repressing p53 target gene transcription is common among DNA tumor viruses based on the finding that SV40 large T-antigen, polyomavirus large T-antigen, adenovirus E1B 19K, …
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Testing the T-loop Model of Telomeric End Protection
… each subunit is dedicated to a specific role in repressing a form of DNA damage signaling, repair, or recruiting telomerase to extend the telomere end. One of the critical anchor points of shelterin is a protein known as TRF2. TRF2 is necessary to protect telomeres from becoming fused by …
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Repression and international conflict
… possible international conflict, but the act of repressing alters their international bargaining power through a signaling mechanism. The argument implies that governments continue to use repression because it can increase their power vis-a-vis both domestic and international opponents. With a …
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Roles for C-ABL and P53 in bone homeostasis and DNA damage response
… and osteoblast-dependent osteoclastogenesis, via repressing the transcription of osterix, an essential osteoblast differentiation factor. Inactivating p53 rescues osteoblast differentiation defects of mice lacking c-Abl, a p53 interacting protein. We provide evidence that c-Abl, a non-receptor …
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MOLECULAR DISSECTION OF THE CROSSTALK BETWEEN ONCOGENIC AND TUMOR SUPPRESSIVE PATHWAYS: THE CASE OF TAZ-BRCA1 AND MYC-SETX GENETIC INTERACTIONS
… the role of the tumor suppressor BRCA1 in repressing the activity of the TAZ oncogene. We characterized a post-translational regulatory mechanism based on the control of TAZ stability/degradation through BRCA1-mediated ubiquitination. This interplay may potentially explain the aggressive …
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Human non-canonical translation initiation factors EIF4E2 and EIF4E3
… a role in cognitive function and development by repressing specific mRNAs. It also can promote tumorigenesis by initiating translation in hypoxia. EIF4E3 seems to have many different functions but its specific role is not known. Its absence in the body can impact development and feeding in …
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CONTROL OF CELL DIVISION AND DIFFERENTIATION IN THE ARABIDOPSIS ROOT - STUDIES ON THE AUXIN RESISTAN 3 (AXR3) GENE
… and accumulation in the stem cell niche by repressing the activities of several PIN auxin efflux facilitators in the AXR3-expressing cells. Together, our results reveal, for the first time, that auxin signaling in the differentiating or differentiated cells could direct cell specification …
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The TAZ Protein Interactome in Striated Muscle
… demonstrate a role for a TAZ/TLE3 complex in repressing the myogenic differentiation machinery having implications for muscle development and regeneration.
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Age and Responses to the Events of September 11, 2001
… age, psychological hardiness and the use of a repressing coping style were found to each individually relate to greater resilience/less dysfunction at both time one and two. For young adults, high hardy repressors faired best, followed by high hardy sensitizers. Low hardy young adults …
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Role of Sonic Hedgehog in Development of the Central Nervous System
… ways: by inducing the neuroectodermal cells, by repressing non-neural cell fates, and by promoting differentiation of neurally committed progenitor cells into motor and dopaminergic neurons.
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Epidermal growth factor-mediated activation of the unliganded glucocorticoid receptor in A549 cells
… whether previously published examples of EGF repressing the expression of interleukin 6 (IL-6) mRNA occur in other cell types and whether the effects of EGF are mediated via the GR. This study provides the first evidence of a single ligand (EGF) causing ligand-independent GR activation, …
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Glucocorticoid receptor signalling and the effect of interleukin 1 beta on glucocorticoid mediated gene expression in intestinal epithelial cell lines Caco-2 and IEC-6
… both cell lines. The regulatory (activating and repressing) effects of dexamethasone on gene transcription in presence or absence of IL-1b were analyzed by reporter gene assay using either glucocorticoid receptor- (pGRE-SEAP) or nuclear factor kappa B responsive element (pNF-kB-SEAP) carrying …
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