Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"reporter virus"”.
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Infection and Dissemination of TaV-GFP Tagged Sindbis in Aedine Mosquitoes and Cell Lines
Arthropod-borne-viruses (arboviruses) pose a global threat due to their ability to be transmitted by hematophagous insects to vertebrate hosts resulting in a range of serious infectious diseases. Sindbis virus (SINV) is the prototype arbovirus of the genus Alphavirus in the family Togaviridae. The …
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Site-Specific Labelling of the Flavivirus Envelope Protein using Genetic Code Expansion
Flaviviruses are arthropod-borne viruses that constitute a significant global public health burden. The envelope protein (E) orchestrates the processes of virus assembly, budding, and entry into cells and is the primary target of neutralising antibodies. The E proteins arranged on the surface of …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
The Human Immunodeficiency Virus (HIV) integrates its genome into the host DNA and persists for the lifetime of the infected cell. Even in the presence of an efficacious Highly Active Anti-Retroviral Therapy (HAART) treatment, a pool of latently infected cells persists and reactivates to produce …
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ESTABLISHING AN IN VITRO MODEL FOR CRISPR-CAS9 SCREENING OF INTERFERON EFFECTORS IN HBV INFECTION
Hepatitis B virus (HBV) is a hepatotropic virus that can cause both acute and chronic liver infection. According to the World Health Organization, 254 million people were living with chronic hepatitis B virus (CHB) infection in 2022, with approximately 1.2 million new cases each year. While …
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Methods for the Genetic Stabilization of Reporter Flaviviruses and their Applications
Infectious reporter flaviviruses have been reported since 2003, and they have the potential to be utilized in diverse scientific areas such as investigating viral pathology, conducting high-throughput drug screens, running rapid serum neutralization tests, and diagnosing disease. Despite the value …
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Methods for the Genetic Stabilization of Reporter Flaviviruses and their Applications
Infectious reporter flaviviruses have been reported since 2003, and they have the potential to be utilized in diverse scientific areas such as investigating viral pathology, conducting high-throughput drug screens, running rapid serum neutralization tests, and diagnosing disease. Despite the value …
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Human Antibody Response to Flaviviruses and SARS-Coronavirus-2
… outbreaks. These include tick-borne encephalitis virus (TBEV), Powassan virus (POWV), Zika virus (ZIKV) and severe acute respiratory syndrome coronavirus (SARS-CoV-2). The first part of this thesis focuses on encephalitis-causing tick-borne flaviviruses, specifically TBEV and POWV. Both TBEV and …
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HIV-1 INFECTION OF NEURAL STEM CELLS RESULTS IN COGNITIVE DEFICITS THROUGH ADULT NEUROGENIC MODULATION
… apoptotic pathways. At the same time, the virus may establish a state of latency in these microglia, perivascular macrophages, and astrocytes, which would allow for the long-term persistence of HIV-1 in the CNS. Recently, several studies have demonstrated that neural stem cells (NSCs) are …