Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"repolarization"”.
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The Pattern of Ventricular Repolarization during Therapeutic Hypothermia
… indicates myocardial transmural dispersion of repolarization (TDR) and increased TDR may create electrophysiological conditions for reentry. We investigate the effect of TH on the pattern of ventricular repolarization including the QTc and TpTe. We investigate 63 patients undergoing TH …
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Monitoring transient repolarization segment morphology deviations in mouse ECG
… partial automation for detection of anomalous repolarization segment morphologies in the ECG of mice. The technology consists of hardware for signal conditioning of the electrocardiogram (ECG); software for the collection, archiving and real-time & retrospective Internet visualization of data; …
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Investigating the coordination of cardiac conduction and repolarization in ventricular myocardium
Aberrations in conduction or repolarization are established prerequisites for arrhythmogenesis. The following dissertation investigates how reducing either ephaptic (EpC) or gap junctional (GJ) coupling between cardiomyocytes can modulate cardiac conduction, repolarization, or the relationship …
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The effects of atrial repolarization on exercise-induced ST-segment depression in apparently healthy females
The relationship between the PQ-segment slope on ST-segment depression during vigorous exercise was examined in 26 apparently healthy females between 18 and 26 years of age. Each subject performed 2 submaximal cycle ergometer exercise tolerance tests (trial A and trial B) on nonconsecutive days …
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Global sequence and dispersion of ventricular repolarization: In vivo validation of non-invasive parameters using monophasic action potential mapping technique
… estimation of global dispersion of ventricular repolarization (DVR), and to investigate the changes of repolarization sequence and DVR by altered ventricular pacing sites. The material consisted of 12 patients (Study I) and two series healthy pigs with 10 in each (Studies II and III; Studies IV …
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Transcriptomic profiling of macrophage polarization
… states which may then impact their future repolarization to new states. In this dissertation, I first describe the evolving understanding of macrophage polarization and phenotypic plasticity and introduce commonly used models for macrophage polarization in humans and mice. I also outline …
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ΣΥΜΒΟΛΗ ΕΙΣ ΤΗΝ ΠΡΟΓΝΩΣΤΙΚΗΝ ΣΗΜΑΣΙΑΝ ΤΩΝ ΠΑΡΑΜΕΤΡΩΝ ΤΗΣ ΔΟΚΙΜΑΣΙΑΣ ΚΟΠΩΣΕΩΣ
… WITH A WIDE RANGE OF CHEST COMPLAINS AND OR REST REPOLARIZATION CHANGES SUBJECTED TO ONE ECGPHIC STRESS TEST, ARE DRAWNTHE FOLLOWING CONCLUSIONS. 1. AS IT CONCERNS THE EVOLUTION OF SYMPTOMATOLOGY:A) ASYMPTOMATICS 20% (FROM A 6%) INITIALLY. B) SYMPTOMATIC IMPROVEMENT 23,9%,C) UNCHANGED …
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Establishing a Mouse Model of Glioblastoma (GBM) And Developing Strategies to Eliminate Cancer Cells.
… flow cytometry to help study curcumin-mediated repolarization of TAMs and recruitment of NK cells to eliminate GBM. Additionally, we attempted to develop CA-CC adducts to achieve repolarization of TAMs and eliminate chemoresistance in the GBM cells.</p>
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Rules of Contact Inhibition of Locomotion for Cell-pairs Migrating on Aligned and Suspended Nanofibers
… of both cells as a cohesive unit in the repolarization direction. Interestingly, for the case of spindle and parallel cell collision, we find the parallel cell to shift the morphology to that of spindle and continue persistent movement without repolarization. To account for effect of cell …
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Local or Systemic Antibody-Targeted Sting Activation Drives Pro- Inflammatory Stromal Metabolic Changes and Downregulates c-MYC Oncoprotein
… of cold tumors by inducing inflammatory repolarization, particularly of the myeloid stroma, thus enhancing T cell priming and infiltration. However, systemic delivery of these small molecule STING agonists has been limited by their rapid diffusion and clearance, as well as the associated …
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Arrhythmias in Pulmonary Hypertension
… linked to slower conduction velocity, prolonged repolarization, and increased AV nodal refractoriness, offering mechanistic insights into arrhythmia development. These findings underscore the need for future research into the benefit of prophylactic arrhythmia screening and intervention in IPAH …
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Neural mechanisms involved in memory formation and retrieval within the rodent hippocampus : an in vivo electrophysiological study
… (Chapter 4), 2) increases in the rate of spike repolarization (Chapter 5), 3) reductions in spike count variability within bursts (Chapter 5), and modulations in burst length both during behavior and sleep (Chapter5).
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Cardiac Fibrosis and Ventricular Arrhythmogenesis: Unravelling the influence of fibrosis on electrical dysfunction in the development of heart failure
… and rate dependent CV slowing /anisotropy and repolarization dispersion. In contrast, while there was an increase in the measures noted above from 12 to 18 months, the differences were less pronounced with a considerable overlap. Arrhythmic susceptibility also increased with age and showed a …
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Automatic detection of qt and related intervals
… which indicated normal duration of ventricular repolarization. The variability plots indicated similarity between HR variability and QT corrected variability.
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The effects of anticholinergic drugs on sea anemones
… is destroyed by acetylcholinesterase causing repolarization so that the muscle is able to respond to further nerve impulses.</p><p>Acetylcholine possesses two actions in vertebrates: muscarinic and nicotinic. The muscarinic action is exhibited at the neuromuscular functions of smooth muscle …
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Effects of Perfusate Composition (Na+ and Ca2+) on Cardiac Electrical and Mechanical Function in the Isolated Langendorff-Perfused Heart
… asystolic. In doing so, elevated sodium prevents repolarization prolongation in these hearts. Together, these studies would suggest that elevating extracellular sodium, and calcium, should be considered as therapeutic targets in the context of conduction defects. However, when considering the …
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Electrophysiological and morphological analyses in two species of insects, Protophormia terraenovae and Ceratitis capitata
… K+ currents involved in the action potential repolarization and repetitive firing of the neurons by way of the Kv channel inhibitors, 4-aminopyridine and 5-hydroxytryptamine. The receptor potential and the spike activity were simultaneously recorded from the ‘salt’, ‘sugar’ and ‘deterrent’ …
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Mapping Ligand Binding Sites in hERG1 Channel with Biomolecular Simulations
… or IKr, which is essential for the normal repolarization phase in the ventricular action potential. The drug-induced blockade of the channel is a frequent side effect of various classes of drugs which can cause QT interval prolongation. The consequent cardiac arrhythmia, known as acquired …
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Characterization of cardiac IKs channel gating using voltage clamp fluorometry
… activating current important in action potential repolarization in cardiac cells). In order to serve these varied functions, KCNQ1 displays uniquely flexible gating properties among Kv channels. Evidence of this flexibility is found in the observation that the presence or absence of various beta …
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