Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"replicative stress"”.
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An investigation into the regulation of replication factories and dormant origins in human cells
… origins are required to help the cells overcome replicative stress caused by barriers to the replication fork. Cells also regulate replication factories in a Chk1-dependent manner in response to replicative stress. The combination of dormant origin activation and inhibition of replication factory …
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Mismatch Repair Protein-Dependent Cytotoxic Signaling In Cells Treated With The Cancer Chemotherapeutic Cisplatin
… p73 proteins, as well as double-strand break and replicative stress respondents ATM, γH2AX and Chk1 occurs independently of MMR protein status upon treatment of cells with CDDP, suggesting that these proteins are not involved in CDDP-induced, MMR protein-dependent cytotoxic signaling. This study …
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The Origin of Genome Instability in Cancer: Role of the Fragile Site Gene Product FHIT
… sites are exquisitely sensitive to agents that stress DNA replication forks, and thus, it is thought that replicative stress is a major source of genome instability in cancer. A frequent and very early genetic alteration in precancerous cells is deletion within fragile site FRA3B, which overlaps …
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The role of Cdc7 and cyclin-dependent kinases in DNA replication and S phase
… essential replication substrates in the event of replicative stress. <br/><br/>In the second part of the thesis, the design strategy for generating a Cdc7-conditional knockout mouse (cko) is outlined and results from the screen for a transgenic founder are presented. A Cdc7-cko mouse will be a …
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Investigating the DNA damage response induced by Typhoid Toxin
… results suggest that toxin-induced damage causes replicative stress by exhausting the cellular pool of RPA. The γH2AX ring pathway was found to drive cells into a senescence-like state, a phenomenon associated with ageing. Induction of senescence via the toxin increased the burden of infection by …
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Relevanz der humanen Xylosyltransferase-I in der Seneszenz-assoziierten Gewebe-Remodellierung und der adulten Knochenhomöostase
… development of cardiac fibrosis. In contrast, replicative stress induced chronic senescence in hCSCs resulted in suppressed XT-I activity, reduced ECM expression and the formation of an immunosupressive SASP. The characterization of XYLT1-deficient hCSCs confirmed that XT-I suppression in …