Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"replicative senescence"”.
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Replicative Senescence is ATM-Driven, Reversible, and Delayed by Reduced ATM Activity at Low Oxygen
… DNA Damage Response (DDR), thereby inducing this replicative senescence. However, the nature of the activated DDR is unclear. ATM kinase activation at critically short telomeres has been implicated in the induction of senescence, suggesting that the shortest telomeres lack su]icient TRF2 to …
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The Effects of Cell Culture Oxygen Levels on the Replicative Senescence Processes of Primary Human Fibroblasts
… non-dividing senescent cells by a process termed replicative senescence. This tissue culture-based methodology is currently used as a model system to determine the underlying mechanisms of in vivo cellular aging and tumor suppression. Senescence is regarded as an alternative pathway to apoptosis, …
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Functional Identification of MicroRNAs Counteracting Cellular Senescence
Cellular senescence is a process closely linked to organismal ageing, and clearance of senescent cells has been shown to revert aspects of the ageing phenotype. We sought to identify miRNAs able to counteract replicative senescence at the cellular level, and investigate their effect in vivo. A …
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Telomere Position Effect in Human Cells
… trigger a state of growth arrest termed replicative senescence.
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Regulatio of actin cytoskeleton by TIS21 vi downregulating reactive oxygen species (ROS) in the doxorubicin-induced premature senescenc
… differentiation and apoptosis. Cellular senescence is an irreversible arrest of proliferation, which is induced by replicative cell division (replicative senescence) or stress (stress induced premature senescence; SIPS). Cellular senescence is induced by DNA damage, telomere shortening or …
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Nuclear accumulation of G-actin in cellular senescence: Reduced expressions of exportin 6 and Ran small G protein
… that actin was accumulated in nucleus during replicative senescence of human diploid fibroblast (HDF). In the present study, we found that the increase of doubling time of HDF cells decreased exp6 and Ran expression as well as phosphorylated cofilin. Concurrently, Ran was transported into the …
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Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
Cellular senescence is a state of irreversible growth arrest induced by either telomere shortening (replicative senescence) or telomere-independent signals (stress-induced premature senescence or SIPS). Recent studies have shown that cigarette smoke extract induces senescence in lung fibroblasts …
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Premature vascular senescence during diabetic retinopathy
Cellular senescence is the permanent state of growth arrest with significant phenotypic changes including the senescence-associated secretory phenotype (SASP) and triggered by mechanisms such as telomere shortening and DNA damage. Diabetes is associated with endothelial dysfunction, which is …
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Nucleolar dynamics in cellular senescence
… dynamic of nucleolar area triggered by different senescence inducers remains elusive. Besides, gene expression associated with enlarged nucleoli is not well understood. Here, I show nucleolar dynamics in different types of cellular senescence including oncogene-induced senescence (OIS), secondary …
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The Effect of Stress Induced Premature Senescence on the Expression of Heterogeneous RibonucleoIeoprotein
… nuclear ribonucleoproteins (hnRNP) in cellular senescence is yet to be defined. Cellular senescence is a terminal growth arrest in somatic cells. It is thought to be the consequence of telomeric shortening that acts as a DNA damage signal. Conversely, cells induced into premature senescence …
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Induction of Cellular Induction Senescence by BTG2_(TIS21/PC3) Gene in Huh7 Hepatocellular carcinoma Cells
… regulator and an important factor for cellular senescence. However, there has been no experimental evidence to confirm TIS21 as a regulator of cellular senescence. In this study, we observed the changes of TIS21 expression in the replicative senescence of human diploid fibroblast (HDF) cells. …
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Telomere Length Studies in Human Cancer Cells
… short length, at which time the cells undergo senescence or apoptosis. Cancer cells which have the ability to divide indefinitely must prevent their telomeres from becoming critically short, and the majority of cancer cells achieve this by upregulating telomerase. Maintaining telomere length …
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Hyporesponsive synovial fluid T cells in rheumatoid Arthritis
… suppressions (TR1 cells and CD25+ TS cells) and replicative senescent T cells suggested that this kind of T cell hyporesponsiveness is different. T cell hyporesponsiveness is obviously induced by a soluble factor, which is present in the synovial fluid of RA patients that contained anergic SF T …
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Repressor of Estrogen Receptor Activity (REA) is a gene dose-dependent coregulator protein affecting estrogen signaling and cell survival
… transcription, mitochondrial biogenesis and replicative senescence. Previous reports suggest that REA is a multifunctional protein with important biological activity. However, despite increasing information, the physiological functions and regulatory mechanisms of REA are still incompletely …
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Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in cellular senescence: molecular and clinical implications.
… capacity in vivo and in vitro, termed senescence and later, thought to contribute to molecular and cellular organismal aging. There are several studies that demonstrate the importance of the GH/IGF axis in longevity, aging and cellular senescence. One primary component of the IGF …
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Regulatory Factors of Cellular Senescence in Human Diploid Fibroblast : SA-p-Erk1/2, PP1/2A, PKCα
… after a certain number of divisions, called replicative senescence, which is paragon of the general process of cellular senescence. Once senescent, cells continue to function metabolically, but will not respond to mitogens. Decreased growth rate, limited cell division, flat and large cell …
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Modeling Sporadic Tumor Formation Driven By Telomere Dysfunction In The Gastrointestinal Tract
… of DNA damage and cells respond by entering into replicative senescence or apoptosis, a process that is p53-dependent and the mechanism for telomere-induced tumor suppression. Loss of this checkpoint and improper repair of dysfunctional telomeres can initiate a cycle of fusion, bridge and breakage …
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Early Blood Cell Formation "in sickness and health, ´till death do us part"
… of old versus young HSC, though without proof of replicative senescence. In agreement with this, we found no evidence for increased p16INK4A signaling in aged HSC, nor for a permissive epigenetic state at the p16INK4A control region. Differentiation from a multipotent HSC to mature blood cells …
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Toward a Quantitative Analysis of PARP-1 and Poly(ADP-ribosyl)ation in Cellular Senescence
… Model systems involving the induction of replicative senescence in cultured cells have been indispensable in elucidating some of the mechanisms underlying this complex process. An understanding of how and why cellular senescence occurs is thus critical to the field of aging research. While …
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Involvement of mitochondrial dysfunction during transforming growth factor β1-induced senescence-like growth arrest of MvlLu cells
… number of population doubling, which is termed replicative senescence. Although the free radical theory has long been implicated in the senescence, recent studies have emphasized mitochondrial DNA hypothesis because mitochondria is the major ROS generator in addition to its high vulnerability to …
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