Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"replication stress response"”.
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DDI1/2 and RTF2-Dependent Regulation of RNASE H2 at the Replisome Ensures Genome Stability
… DNA Damage Inducible 2 (DDI2), are active in the replication stress response (Kottemann et al., 2018). Under conditions of replication stress, DDI1/2 function to remove Replication Termination Factor 2 (RTF2) from the replisome. Persistence of RTF2 at the replisome compromises the replication …
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A Neural Network and Genome Language Model Based Approach to Understanding DNA Replication in Cancer
… daughter cells. This process is called DNA replication. DNA replication differs between healthy cells and cancer cells and can be exploited as a therapeutic target. At the same time, altered replication dynamics are critical for understanding cancer onset, evolution and treatment resistance. …
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THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS
… marks are faithfully inherited during DNA replication through tightly coordinated processes. Our recent work demonstrated that disruption of DNA replication, known as replication stress, can expand the cell fate of mouse embryonic stem cells (mESCs) by activating totipotency and …
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Metabolic regulation of mammalian cell growth and proliferation
… not sensed until cells enter S phase, when the replication stress response becomes critical for cell survival. Moreover, we found that replication stress sensing promotes nucleotide availability during normal S phases, suggesting that proliferating cells enter S phase without sensing whether …
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The Crosstalk Between DNA Mismatch Repair and Replication
DNA replication fidelity relies on DNA mismatch repair (MMR) and the proofreading nuclease activity of DNA polymerases. Normally, biosynthetic errors can be removed by the polymerase's proofreading nuclease activity upon their incorporation, and those errors that have escaped the proofreading …
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Brit1/Mcph1 Mediates The Dna Damage Response By Inducing P53 Stability and Promoting Atr Signaling
… to repair DNA double strand breaks (DSBs). In response to DSBs, BRIT1 foci form at damaged sites, and recruits downstream repair proteins including 53BP1, MDC1, NBS1, and the SWI/SNF complex to the DSB region to promote DNA repair. <em>BRIT1</em> copy number deficiency correlates with increased …
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
… as a newly identified cancer driver gene. Replication stress (RS) threatens DNA replication fidelity and stability of the genome. Recently, a small number of AU-RBPs have emerged as key figures in the maintenance of genome integrity through mechanisms that govern the replication stress …
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The DNA damage response to ATR inhibition
… ATR is an apical regulator of the DNA damage response and coordinates DNA repair, cell cycle checkpoint engagement, and DNA replication to ensure genome stability. To achieve this, ATR signalling often cooperates with, or antagonises, other DNA repair pathways, including many known and …
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Low Molecular Weight Cyclin E Deregulates Dna Replication and Damage Repair to Promote Genomic Instability In Breast Cancer
… promotes genomic instability by deregulating DNA replication and damage repair. We generated immortalized pre-cancerous human mammary epithelial cells (hMECs) engineered to express doxycycline inducible LMW-E or FL-cycE in <em>CCNE1</em> knock-out background. We found that, unlike LMW-E, FL-cycE …
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Functions of RTF2 in DNA Replication and Checkpoint Control
… has uncovered one such dynamic process at replication forks experiencing replication stress, by which proteasome shuttle proteins DNA damage inducible 1 and DNA damage inducible 2 (DDI1/2) regulate the level of replication termination factor 2 (RTF2) at the replisome. When RTF2 is retained …