Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"replication organelle"”.
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Characterization of the GBF1-Arf1 axis in enterovirus RNA replication
… of specialized domains harboring viral replication complexes, called replication organelles. The cellular protein Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1) is essential for the replication of enteroviruses, but its molecular role in the replication …
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Structural and Functional Studies of the SARS-CoV-2 NiRAN Domain
… shed light on the mechanisms underpinning viral replication and gene expression in the hope to elucidate biology conserved across viruses and better define therapeutic targets. The enzymatic activity of the SARS-CoV-2 Nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain is essential …
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Prenylation in cell-intrinsic innate immunity to positive-strand RNA viruses
… compartment can be utilized by viruses for replication, antiviral factors must also be positioned in these compartments to effectively interact with various viral threats. In this thesis, we explored the impact organelle membrane targeting through protein prenylation has on the antiviral …