Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"replication factor C (RFC)"”.
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Molecular and Biochemical Analyses of a Three-Subunit Euryarchaeal Clamp Loader Complex
DNA polymerase requires two processing factors, sliding clamp and clamp loader, to direct rapid and accurate DNA replication. In eukaryotes, the ring-shaped sliding clamp, proliferating cell nuclear antigen (PCNA), encircles double-stranded DNA within its central hole and tethers the DNA …
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Comparative Studies of Processivity Clamp Loader ATP Site Function
… site B or C causes inactivation of γ complex. Replication factor C (RFC) loads the processivity clamp, proliferating cell nuclear antigen (PCNA), onto DNA. ATP binding to RFC activates a γ-phosphate sensor in ATP site C that promotes DNA association by RFC-PCNA. DNA binding to the RFC-PCNA …
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Replication-associated base excision repair Of oxidized bases in the mammalian genome
… that mimic intermediates generated during DNA replication. This suggests a direct linkage of NEIL1’s repair activity to genome replication. In addition, inactivating mutations in the NEIL1 gene have been epidemiologically linked with gastric cancer, NEIL1-downregulation induces a mutator …
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Single-molecule and ensemble studies of DNA replication system
DNA replication is one the most important and complex systems in biology. In this dissertation, we first started from ensemble experiments, studying the clamp (PCNA) and the clamp loader (RFC) from the mesophilic archaeon Methanosarcina acetivorans, and then moved to the single-molecule level …
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Making Molecular Movies: Using Single-Molecule Techniques to Unveil Hidden Features of Protein-Chromatin Interactions
… described. Chapter 4 discusses a study on DNA replication, specifically the dynamics of the eukaryotic sliding clamp, proliferating nuclear cell antigen (PCNA). PCNA is an essential ring-shaped protein required for replication in addition to diverse cellular processes including DNA repair, …