Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"repetitive elements"”.
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Comparative genomics of repetitive elements between maize inbred lines B73 and Mo17
The major component of complex genomes is repetitive elements, which remain recalcitrant to characterization. Using maize as a model system, we analyzed whole genome shotgun (WGS) sequences for the two maize inbred lines B73 and Mo17 using k-mer analysis to quantify the differences between the two …
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Variable DNA methylation in the mouse genome: repetitive elements, unique regions and functional implications
… murine-specific intracisternal A particle (IAP) elements. To prevent their mobilisation and suppress the function of the TE- encoded regulatory sequences, TEs are generally targeted by repressive histone modifications and DNA methylation. The Avy allele results from an IAP insertion into the …
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Identification of Factors Involved In Dna Methylation of Cpg-Island-Promoters
… promoters are surrounded by or contain clustered repetitive elements. It was previously observed that a sharp transition of methylation occurs between highly methylated repetitive elements (SINE or LINE) and unmethylated CGI-promoters (e.g. P16, VHL, CDH and RIL) in normal tissues. The functions …
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Mobile genetic element contribution to the genome architecture of the human parasitic flatworm Schistosoma mansoni
… Its genome is repeat-rich, with transposable elements (TEs) comprising approximately 35% and Schistosoma-specific W elements (WEs) an additional 10%. Repetitive elements have a profound impact on host genomes, directly contributing to protein-coding genes via transposition in a process known …
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The involvement of non-B DNA forming sequences in mediating missense mutations, micro-deletions and micro-insertions in human inherited disease
… involvement of the local DNA sequence features (repetitive elements capable of adopting non-B structures, hotspot motifs, mononucleotide runs and tandem repeats) and epigenetic marks in mediating germline missense and nonsense mutations, micro-deletions and micro-insertions causing human …
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Order and disorder: a hotel in Alexandria, Virginia
The main theme to investigate repetitive elements included an investigation into the limits of monotony and an addition of an exception to their rank, that is why the design for a hotel has been chosen. The secondary theme to crystallize my beliefs about urban design was possible by choosing a site …
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Non-Parametric Analyses of the Regulatory Roles of LINE-1 Retrotransposons during Motor Neuron Differentiation
Background: Repetitive elements make up a large portion of eukaryotic genomes, constituting two-thirds of human genome. Although their functional importance were recognized as early as 1950s, study of their functions is stagnated despite the advancements in next-generation sequencing due to …
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De novo assembly of transcriptome and genome data from the Asia I mtCOI genetic clade of Bemisia tabaci
… 41,981 PCGs and also contained 990 ncRNAs and repetitive elements (45.66%). A selection of 741 full-length genes were studied and found to contain larger intron sizes together with repetitive elements that contribute to the larger Asia I genome size and partly explain the difficulties …
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Dissecting the role of CHD4 in the NuRD and ChAHP complexes
… which contributes to silencing of transposable elements (TEs). CHD4 generally functions to increase nucleosome density, however the specific chromatin remodelling mechanisms employed by NuRD and ChAHP to regulate gene expression and repress repetitive elements have not been fully characterised. …
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Comparative genomics of chromosomal rearrangements in malaria mosquitoes
… of inversion fixations and highest density of repetitive elements. Among the autosomes, 2R evolved faster than other autosomes. The slowly evolved autosomes have more M/SARs than rapidly evolving arms. Breakpoint regions are enriched with repetitive elements. The study revealed that fixed …
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LIA4 and HP1-like Proteins Facilitate DNA Elimination During Tetrahymena Macronuclear Development
… genome-wide removal of transposon-like and other repetitive elements. This process, referred to DNA rearrangement, involves RNAi-directed formation of subnuclear heterochromatic foci. Many of the factors necessary to direct the DNA rearrangement machinery to proper loci have been discovered, but …
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GENOMIC AND EPIGENETIC APPROACHES IN THE CLINICAL AND PROGNOSTIC STRATIFICATION OF CHRONIC LYMPHOCYTIC LEUKEMIA
… sequences, such as long interspersed nuclear elements-1 (LINE-1), Alu and satellite α DNA (SAT-α DNA), reported to be associated with chromosomal instability. Our analysis was performed in a panel of 77 CLLs and 7 healthy donors using robust quantitative Pyrosequencing methodology to detect …
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Transposable elements: What have you done for me lately? A genomics based investigation into the potential functional roles of transposable elements using the model organism Caenorhabditis elegans
… discrete DNA sequences present as disperse repetitive elements called transposons. Transposons have the unique ability to move to new chromosomal locations. Problems of uncontrolled movement of transposons can result in mutations, rearrangement, and even broken chromosomes. Often termed …
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What's going on here
… Semi-logic of What’s going on here while adding repetitive elements to clarify the existence of the Semi-logic. The arrangement of the Components in the installation makes the Unrecognizable forms surrounded by the In-between Space into somewhat Recognizable versions of shirts and pants. The …
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Characterization of interplay among DNA repair, histone H3 lysine 9 dimethylation and small interfering RNA pathway in Caenorhabditis elegans
<p>Heterochromatin assembly on repetitive sequences has been proposed to maintain genome integrity in different species. Histone H3 lysine 9 dimethylation (H3K9me2) has been shown to play an important role in mediating the formation of heterochromatin. In our lab, we use Caenorhabditis elegans as a …
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The organization and evolution of heterochromatin in the Anopheles gambiae complex
… fully assembling a genome is the abundance of repetitive sequences. These sequences, typically part of gene poor regions known as heterochromatin, are generally left as unassembled scaffolds that are neglected in many genomic studies. Heterochromatin is a biologically important chromatin state …
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DNA DAMAGE AT TANDEM REPEATS GENERATES I-LOOPS THAT CAN BE EXCISED AS ECCDNA
… the i-loop formation and excision model at other repetitive elements. Using genome-wide damage or through targeted CRISPR-Cas9 nickase (nCas9)-induced nicks we show that, apart from telomeres, i-loops are formed as a consequence of DNA damage also at centromeric α-satellite repeats. As in the case …
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Dicer deletion and short RNA expression analysis in mouse embryonic stem cells
… in the silencing of protein-coding genes and repetitive elements in genomes. In mammals, it is unknown to what extent RNAi is involved in silencing processes other than the modulation of protein-coding gene expression, which is achieved through a class of short RNAs termed microRNAs (miRNAs). …
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Design and Optimization of Post Disaster Relief Structure
… tools for assembly, utilizes all prefabricated elements, and meets the region's building codes for a typical residential home. Ultimately, the structure is a shelter that can be reused year to year by being assembled and disassembled as needed. This will help to reduce material waste and the …
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Characterizing variation at short tandem repeats and their role in human genome regulation
… a unique mapping strategy to rapidly align repetitive reads, and uses statistical learning techniques to account for STR-specific noise patterns. We applied lobSTR to generate the largest and highest quality STR catalog to date. This provided the first characterization of more than a million …
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