Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"repetitive DNA"”.
-
Repetitive DNA sequences in maize: Possible roles in plant adaptation and transient gene expression
Fluctuations as high as 40% in the nuclear DNA content in maize have been observed as a result of adaptive response. The knob DNA sequence has been reported to contribute 16% of this variation. Other DNA sequences involved in genome size variation due to adaptive response have yet to be identified. …
-
RNA-binding Proteins and RNA-DNA Hybrids Regulate Repetitive DNA Stability in Health and Disease
… is essential to proper cellular function. Repetitive DNA sequences, such as the ribosomal DNA repeats (rDNA) and transposons, represent a large portion of eukaryotic genomes. Due to their repetitive nature, these loci are prone to aberrant recombination. In fact, rDNA repeat instability and …
-
Non-Coding Genomics of Methanocaldococcus Jannaschii: A Survey of Promoters, Non-Coding RNA Genes, and Repetitive DNA Elements
… promoters, non-coding RNA genes, and novel repetitive DNA sequences. Genome-wide identification of transcription factor binding sites revealed archaeal core promoter elements, which include TATA box, BRE, and an initiator element. The structural similarity between archaeal basal promoters …
-
Variation and Divergence of Repetitive DNA Sequences With Partial Identity to the Knob Sequence in Tripsacum and Zea
Sequences with various levels of homology to knob have been isolated from T. dactyloides. These sequences have various degrees of cross-hybridization to knob and are apparently arranged differently in the genome as ascertained by southern blotting. Phylogenetic variation of these sequences …
-
Transcriptional Regulation of the Xenopus MyoD Gene
… to maintain the expression of XmyoD gene. A repetitive DNA sequence was discovered in the -2.8/-2.0kb region in the XmyoD genomic sequence. The repetitive DNA sequence in the XmyoD gene locus may produce sense and anti-sense transcripts. In addition, several potential regulators have been …
-
Telomere Position Effect in Human Cells
Telomeres are tracts of repetitive DNA that cap the ends of linear chromosomes. Each time the chromosome is duplicated, a small amount of telomeric DNA is lost from the end due to factors inherent in the mechanism of DNA replication. The result is a net shortening of telomeres with each cell …
-
Development of DNA markers and the genetic analysis of seven populations of the freshwater mussel Lampsilis radiata siliquoidea (Bivalvia: Unionidae) in north central Minnesota
… central Minnesota. Random amplified polymorphic DNA (RAPD), heteroduplex, and single-stranded conformational polymorphism (SSCP) analyses were performed using nuclear DNA markers. We assayed the populations for variation using a single repetitive 18 base pair RAPD primer and two loci that flanked …
-
Centromere Identity and the Nature of the Cenp-A-Containing Nucleosome
… and meiosis. While most centromeres form on repetitive DNA, the underlying DNA sequence is neither necessary nor sufficient to support centromere function, suggesting that this locus is epigenetically defined. The histone H3 variant centromere protein A (CENP-A) replaces H3 in nucleosomes at …
-
Linking genome organization to nuclear function in astrocytes and muscle cells
… changes in the interaction profiles of certain DNA regions are directly correlated with the transcriptional changes that accompany the muscle development. Interestingly, muscle specific genes show a tendency to interact with other muscle specific genes upon muscle cell differentiation. I also …
-
Cloning of actin genes from a genomic library of the newt, Notophthalmus viridescens
… actin homologous sequences within the newt DNA inserts which were subcloned into the plasmid pTZ19R. The recombinant plasmids were transformed into the Escherichia coli strain, DHsa. Detailed restriction maps were produced of the 5.7Kb and 3.1Kb newt DNA inserts in the plasmids, designated …
-
Transcriptional and Chromatin Disorientation Associated with BRCA2 Inactivation
… maintenance via homologous recombination repair, DNA replication fork protection, and R-loop resolution. However, the mechanism by which BRCA2 inactivation causes cancer remains unclear. In this study, using RNA-seq and ATAC-seq I investigated whether BRCA2 acts as a tumour suppressor via …
-
A regulatory role for repeated decoy transcription factor binding sites in target gene expression
Repetitive DNA sequences are prevalent in both prokaryote and eukaryote genomes and the majority of repeats are concentrated in intergenic regions. These tandem repeats (TRs) are highly variable as the number of repeated units changes frequently due to recombination events and/or polymerase …
-
Molecular-cytogenetic analysis of repetitive sequences in genomes of Beta species and hybrids
… beet Beta vulgaris has a genome size of 758 Mbp DNA with estimated 63 % repetitive sequences and the number of chromosomes n=9. The wild beet Beta procumbens is an important natural pool of resistance against pests and tolerance to unfavorable growth conditions. The subject of this research was …
-
Telomere Length Studies in Human Cancer Cells
Telomeres consist of repetitive DNA sequences and their associated binding proteins, and serve to protect linear chromosome ends from being recognized as double stranded breaks in need of repair. The telomeres of most normal diploid cells shorten with every cell division until they reach a …
-
Development of embryonic stem cells expressing endogenous levels of a fluorescent protein fused to the telomere binding protein TRF1
Telomeres are the repetitive DNA sequence and associated proteins found at the ends of linear chromosomes. They have a role in biological processes including meiosis and aging as well as implications in a number of genomic instability disorders and cancers. Telomeres maintain genomic stability by …
-
The Role of 53BP1 in DNA Double-Strand Break Repair
<p>DNA double-strand breaks (DSBs) are dangerous insults to DNA integrity and can lead to genome instability if left unrepaired. However, the immune cell diversification reactions V(D)J recombination and Class Switch Recombination (CSR) require the formation of DSB intermediates, a process that is …
-
Chromosomal Evolution of Malaria Vectors
… formation in Anopheles mosquitoes includes repetitive DNA such as transposable elements (TEs), tandem repeats (TRs) and inverted repeats (IRs). This dissertation provides physical maps for two important malaria vectors, An. stephensi and An. albimanus (Ch.2 and Ch. 3) and then applies those …
-
Telomere Dynamics and End Processing in Mammalian Cells
Telomeres are repetitive DNA sequences that end in single-stranded 3' overhangs. With each cell division, normal human cells lose a small amount of telomeric DNA due to the end-replication problem and the action of an unidentified nuclease. In order for tumor cells to divide indefinitely, they …
-
Development of intermonoploid somatic hybrids of potato and their molecular analysis based on polymorphism for retroelement Tst1
… genome, a tobacco anther-specific gene, repetitive DNA, and the phytochrome F gene.
Page 1 of 2