Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"repeat protein"”.
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Structure/Function Studies on Vps9 domain-containing Ankyrin Repeat protein (VARP)
Vps-9 domain ankyrin repeat protein (Varp) is a widely expressed multi- domain protein of 1050 amino acids that resides in the cytosol. Varp has been shown to be a Rab21 GEF, a Rab32/38 effector and also helps to regulate VAMP7 fusion activity. Varp has more recently been proposed to bind to the …
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Identification and characterization of GRP50 : a novel Golgi-associated ankyrin repeat protein
… of a novel gene, GRP50 (Golgi-associated ankyrin repeat protein of 50 kilodaltons), which encodes a highly conserved mammalian protein exhibiting a unique structural architecture. Homology searching tools reveal that no known orthologues of this protein have been identified in other species, …
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Validating the WD Repeat Protein CDC40 as a Potential Therapeutic Target for Lung Cancer
… the mRNA transcript of the cell cycle regulatory protein CDCA5, a potential prognostic marker for cancer, and showed that CDC40 knockdown induced retention of its first intron leading to an increase in the unspliced CDCA5 transcript, and subsequent decrease in CDCA5 protein expression. Finally, I …
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Investigation of the role of a large serine rich repeat protein in Streptococcus pneumoniae
… in the pneumococcus encodes a large serine rich repeat protein, glycoysltransferases and secretion proteins, some of which are homologous to the Sec secretion pathway. Similar loci have been characterised and found to be important in the virulence of other gram positive bacteria, including …
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Engineering mono- and multi-valent inhibitors on a modular repeat-protein scaffold to target oncogenic Tankyrase
Tandem-repeat proteins are a class of proteins ubiquitous in nature and exploited in recent years in biotechnological and pharmaceutical applications due to their favourable biophysical properties. One such repeat motif, the tetratricopeptide repeat (TPR), has already been exploited for …
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Characterization of the vaccinia virus ankyrin repeat protein K1 on NF-κB inhibition and its contributions to viral pathogenesis
… was to examine how the vaccinia virus (VACV) K1 protein, which is encoded by the K1L gene, modulates the immune response in vitro and in vivo. In vitro, the K1 protein has multiple immunomodulatory effects in tissue culture models of infection. We have previously published that the K1 protein …
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Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2
… gene, which encodes a poly-glutamine (polyQ) repeat protein. Despite widespread expression of the HTT gene, HD presents with massive neuronal cell loss and transcriptional dysregulation primarily in the striatum and deep layers of the cortex. Synaptic dysfunction and motor deficits are also …
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Ehrlichia chaffeensis mediates Hedgehog and Hippo signaling to activate an anti-apoptotic cellular program
… defenses through mechanisms executed by tandem repeat protein (TRP) effectors secreted by the type 1 secretion system. In the past decade, tandem repeat protein TRP120 has emerged as a model moonlighting effector. Remarkably, TRP120 has been defined as a nucleomodulin, ligand mimic and ubiquitin …
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Investigating the Non-globular Proteins of the Canonical Wnt Signalling Pathway
… of adult tissues. The twelve Armadillo (ARM) repeat-containing protein beta-catenin acts as the signal transducer in this pathway and is continuously degraded in the cytosol by the beta-catenin destruction complex (BDC). Upon receiving the Wnt signal the BDC is inactivated, allowing …
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Identification and Classification of Novel Gene Products Involved in Development and Regeneration in Xenopus Laevis
… is a novel member of the neuronal leucine-rich repeat protein family. Protein knock down assays have shown that this protein acts autonomously during differentiation of lens fiber cells and cells of the neural retina. Through elucidating our understanding of molecular mechanisms behind initial …
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A study of Notch signalling in developmental angiogenesis
… stalk cell. The Notch-regulated ankyrin repeat protein, Nrarp, is a Notch target gene that is highly expressed in stalk cells and endothelial cells located at vessel branchpoints. Deletion of Nrarp in mouse and morpholino knockdown of nrarp-a and nrarp-b in zebrafish resulted in decreased …
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WDR5 Network Analysis Using Ensemble Approaches
<p>Understanding the properties of protein-protein interactions (PPIs) is necessary to deconvolute the processes inside living organisms. As such, research in this regard has significant implications for gaining insight into cancers and other diseases. Once understood, drugs can be designed to …
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An interdisciplinary study of the mechanical and dynamic properties of α-solenoid repeat proteins
Tandem-repeat proteins differ from globular proteins, both in their biophysical characteristics and in how they interact with their respective partners, yet they comprise nearly one third of the human proteome and are central to many cellular processes and disease phenotypes. Repeat proteins have …
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Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
The inhibition of protein-protein interactions (PPIs) presents a major challenge to drug discovery. The properties of consensus-designed tetratricopeptide repeat proteins (CTPRs) make them very amenable to be rationally-designed into potential new PPI inhibitors. This study sets out to investigate …
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Identification of Phosphorylase Kinase Alpha Subunit Binding Partners in Skeletal Muscle
… to associate extrinsically with skeletal muscle proteins due to its peripheral location in the holoenzyme. To identify potential muscle protein interactors, the C-terminus of α , amino acid residues 1060-1237, was screened against a rabbit skeletal muscle cDNA library via a yeast two-hybrid …
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Complement in Disease - Extracellular Proteins as Complement Regulators
… cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. The aim of this thesis is to find new interactions between cartilage components and complement, which could provide useful information …
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Stability, folding and evolution of the tumour suppressor protein p16.
The tumour suppressor protein, p16, is a member of the INK4 family of inhibitors of the cyclin D-dependent kinases 4 and 6 in the pRb pathway of eukaryotic cell cycle. The 156-amino acid protein consists of four ankyrin (ANK) repeats. The ANK repeat is a ubiquitous 33-residue sequence motif that …
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Identification and characterization of the inlGHE gene cluster of Listeria monocytogenes
… These genes, termed inlG, inlH and inlE, encode proteins of 490, 548 and 499 amino acids, respectively, which belong to the class of large, surface-bound internalins. Each of these proteins contains a signal peptide, two regions of repeats (Leucine-rich repeats and B repeats), an inter-repeat …
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Dissecting the puncturing device of the Type VI Secretion System: role of Hcp, VgrG and PAAR proteins in assembly and secretion of effectors
… bacteria, which is used to deliver toxic proteins (“effectors”) directly into target eukaryotic or prokaryotic cells. As a result, this system plays a crucial role both in direct pathogenicity and in interbacterial interactions, including polymicrobial infections. T6SSs are encoded within …
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Inducing Chirality in CdS Nanocrystals with Biomolecules
… chiral biomolecules, like peptides and proteins, to generate chiroptical responses in these materials. Chapter 1 reviews the synthetic tunability of CdE NCs and current approaches of synthesizing chiral nanostructures. It then introduces the structural complexity of biomolecules and …
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