Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"repair system"”.
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Development Of A High Strength Laminate Repair System
<p>Composite manufacturing often requires repairs at some point during the life of the part. Working with LM Wind Power, the Chemical and Mechanical Engineering Departments at the University of North Dakota worked to develop a new laminate repair system to be used in composite repairs. Both …
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The role of deficient mismatch repair system in Lynch syndrome and the increased risk of colorectal cancer
… the result of germline mutations in DNA mismatch repair genes (Yurgelun & Hampel, 2018). Analysis of individuals and families with Lynch syndrome found that patients had defects specifically in chromosomes 2, 3 and 7 (Zhang et al., 2015). The significance of these chromosomes was later discovered …
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Determination of Mutation Rates in Bacteriophage T4 by Unneighborly Base Pairs and a Genetic Analysis of the Error-Prone Repair System of Bacteriophage T4
Earlier studies showed that the 2-aminopurine-induced mutation frequency of a particular base pair can be influenced by the base pair adjacent or penultimate to the measure site. This study extends to 0.3 map units (about 20-80 base pairs) the distance at which a single base-pair substitution can …
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Evaluation of Steel H-Piles with Localized Corrosion and Rehabilitation Using Friction-Type Bolted Steel Plates
… bolted steel plate-based rehabilitation system to be used for the repair of corroded piles. To accomplish the first research objective, an investigation of the remaining compressive capacity of H-piles with simulated corrosion was carried out. This included an experimental program and …
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Sanitizing private data for repair systems
The SOLAR system helps restore interconnected system integrity after security attacks with a focus of minimizing the exposure of sensitive data in the repair logs. It builds upon Warp, a repair system for Django web applications which logs all major actions taken by the server from incoming request …
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Discovery and characterization of novel RNA repair systems
… way to respond RNA damage. However, RNA repair is an alternative way for cells to deal with RNA damage, which may play an important role in maintenance of cellular RNAs and even for cell survival. RNA repair is the mechanism that rectifies the purposeful RNA damage during RNA processing …
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Data structure repair using goal-directed reasoning
… This dissertation presents a new data structure repair system that accepts a specification of key data structure consistency constraints, then generates repair algorithms that dynamically detect and repair violations of these constraints, enabling the application to continue to execute …
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Residual restoration of DNA lesions in Deinococcus radiodurans mutants indicate presence of a bypass UV-repair process
The differing UV-susceptibility and UV-damage repair capability of the Deinococcus radiodurans strains and the hypothesis of a bypass repair system have been investigated. The results obtained provide evidence that UV radiation engenders synergistic effects in combination with other stressors like …
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Biochemical and Structural Studies of RNA Modification and Repair
"""RNA Repair"" is a mechanism that rectifies purposeful breaks in tRNAs and mRNAs occurred during RNA processing and under cellular stress. To date, only two repair-like and repair pathways have been identified: yeast-type and phage-type, respectively. In our studies, we identified a bacterial RNA …
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Modulation of DNA repair pathway after CRISPR/Cas9 mediated Double Stranded Break
The CRISPR/Cas9 system has become the predominant tool for genome editing. Targeted modifications can be introduced while repairing double strand breaks (DSBs), induced by the CRISPR/Cas9 system. The DSB is repaired by either non-homologous end joining (NHEJ) or homologous recombination (HR), and …
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Who Cares? Assemblies of Care-and-Repair
… reuses these construction materials through a system of assemblage that maximizes the amount used, and catalogues these materials in a prototypical storage warehouse that not only stores discarded standard timber but is itself built from it. The more material used, the less sequestered carbon …
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ANALYSIS OF HUMAN DNA MISMATCH REPAIR IN THE CHROMATIN ENVIRONMENT
Mismatch repair corrects errors made during DNA replication and inactive mismatch repair is associated with Lynch Syndrome and sporadic cancer. Genome replication in eukaryotes is accompanied by chromatin formation. The first step in chromatin establishment is nucleosome assembly, that starts with …
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Probing substrate specificity of RNA repair protein Pnkp/Hen1 from Anabaena variabilis
… study of the substrate specificity of a RNA-repair protein Pnkp/Hen1 from bacteria Anabaena Variabilis. Following the previous discovery of a RNA repair protein—Pnkp/Hen1, which can repair ribotoxin cleaved tRNA in vitro and can add a methyl group at the cleaved site to prevent further …
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A Study of genetic instability and DNA repair in selected mutants of streptomyces cattleya
… cattleya NRRL 8057 with lesions in the DNA repair pathway were obtained by NTG mutagenesis. The mutants were selected on the basis of their resistance or sensitivity to Mitomycin c. Of the three mutants, two, R6 and Rl2, were selected as MMC resistant and one, S26, as MMC sensitive. They …
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Visualising the Mycobacterial Mutasome
An SOS-inducible DNA repair system has been linked to transient hyper-mutation and the development of drug resistance in Mycobacterium tuberculosis. Previous work has established that this “mycobacterial mutasome” comprises the specialist DNA polymerase, DnaE2, and accessory factors of unknown …
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Design and fabrication of micro- and nano- dielectric structures for imaging and focusing at optical frequencies
… In the diffraction regime, two types of optical systems and optical elements were investigated for application in LCD manufacturing. With the increasing demand for larger LCD screens at lower cost, technology for low-cost high-throughput manufacturing systems, as well as efficient repair systems …
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Modeling Autism Spectrum Disorder: Fragile X syndrome and Rett syndrome
… there must be equally rigorous attention to the systems employed to model these genetics in order to ensure accurate insights into their pathophysiology and treatment options. We sought to extend the current state of animal models for two of the most prevalent monogenic causes of ASD and …
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Role of The Immune System In The Modulation of The Mmr-Deficient Intestinal Stem Cell Niche
<p>Mismatch Repair (MMR) is a crucial DNA repair system to maintain genomic integrity in cells that is integrated by specific genes including <em>MLH1</em>, <em>MSH2</em>, <em>MSH6</em>, and <em>PMS2. </em>These genes play a critical role in repairing errors that occur in base pairing by …
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REGULATORY PROCESSES IN ULTRA SLOW GROWING MICROORGANISMS (ESCHERICHIA COLI, BACILLUS POLYMYXA)
… throughout the phases.</p><p>The inducible DNA repair system, "SOS", can be activated in phase 3 cultures of E. coli. The degradation or turnover of proteins involved with this system, is apparently very slow, if compared with the rates of degradation of the inducible enzymes, B-galactosidase …
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Optimization and Translation of MSC-Based Hyaluronic Acid Hydrogels for Cartilage Repair
… cartilage as a biologic approach to cartilage repair. Research utilizing autologous chondrocytes has been promising, but clinical limitations in their yield have motivated research into the potential of mesenchymal stem cells (MSCs) as an alternative cell source. MSCs are multipotent cells that …
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