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Showing 1 to 20 of 79 for “"renin-angiotensin system"”.
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RADIATION-INDUCED BRAIN INJURY AND THE RENIN-ANGIOTENSIN SYSTEM
… CNS has been pharmacologic suppression of the reninangiotensin system (RAS). The brain has its own intrinsic RAS which has effects beyond cardiovascular and fluid homeostasis including learning, cognition and memory. Although the pathogenesis of radiation injury remains unclear, we hypothesize …
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Studies of the renin angiotensin system in the human vasculature
The work presented in this thesis concentrates on the local generation of AII. Preliminary experiments using wire myography were performed in human resistance arteries from normal subjects, obtained by subcutaneous gluteal at biopsy. In these vessels, AI stimulated a contractile repose that was …
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The Renin-Angiotensin System in The Freshwater Turtle Pseudemys Scripta
… to verify the existence of an endogenous renin-angiotensin system in this species. It was shown that Pseudemys scripta possess renal renin, renin substrate in the plasma, angiotensin converting enzyme activity, and vascular receptors specific for angiotensin. Kinetic analyses were …
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Investigating the role of the Renin Angiotensin System in cancer
… diseases as possible anti-cancer agents. The renin-angiotensin system (RAS) regulates blood pressure and cardiovascular homeostasis through Angiotensin Converting Enzyme-1 (ACE-1) and its homolog ACE-2. RAS has also been implicated in the progression of various cancers due to the increased …
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Factors Regulating the Intrarenal Renin-Angiotensin System and Renal Damage During Aging
The renin-angiotensin system (RAS) plays an important role in regulating blood pressure, fluid homeostasis, and it even contributes to insulin resistance. Dysfunction of this system ultimately leads to cardiovascular related diseases, such as hypertension and diabetes. Studies show that RAS …
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The Brain Renin-Angiotensin System: Biochemical Characterization and Possible Role in Hypertension
A renin-angiotensin system (RAS) endogenous to the brain has been proposed on the basis of immunochemical, biochemical and pharmacological evidence. Angiotensin II exerts potent effects in CNS tissues and appears to be involved fluid balance homestasis and blood pressure regulation. The data in …
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Alterations in the Brain Renin-Angiotensin System in a Model of Fetal Programming
… and activating the sympathetic nervous system. However, fetal steroid exposure may lead to elevated mean arterial pressure and decreased autonomic function in young adults. Baroreflex sensitivity for control of heart rate is an important marker of autonomic function and is reduced in …
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Sex-Related Differences in Hypertension and Renal Injury: Role of the Renin-Angiotensin System
… rate in men than in premenopausal women. The renin-angiotensin system (RAS) contributes to the development and maintenance of hypertension. Angiotensin II (Ang II) and angiotensin-(1-7) are two peptides derived from the RAS that possess vasoconstrictive and vasodilatory actions, respectively. …
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AEROBIC FITNESS AND THE RENIN ANGIOTENSIN SYSTEM IN ADOLESCENTS BORN PRETERM WITH VERY LOW BIRTH WEIGHT
… during key developmental windows alter organ system structure and function that promotes survival in the short-term, but may be detrimental in the long-term, leading to higher risk for developing chronic diseases such as hypertension, cardiovascular disease, and diabetes later in life.6,7 The …
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STUDIES ON ANGIOTENSIN-(1-7) AND MITOCHONDRIA: THE ROLE OF AN INTRACELLULAR RENIN-ANGIOTENSIN SYSTEM WITHIN THE KIDNEY
… failure target a classic circulating hormonal system - the renin-angiotensin System (RAS), and specifically, the ACE-Ang II-AT1 receptor axis. We have focused strategically on investigating novel intracellular pathways by which Ang-(1-7) is generated and degraded since this alternative pathway …
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The cardiovascular effects of the pharmacological interruption of the brain renin-angiotensin system in Dahl salt-induced hypertension
Made available in DSpace on 2011-05-07T13:01:59Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9416390.pdf: 5287338 bytes, checksum: 7ad9cc893a5c5e88bc49745c02568e9f (MD5) Previous issue date: 1994
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Regulation of Substrate Metabolism and Renin-Angiotensin System with Dietary and Pharmacological Interventions: Implications for Obesity and Related Disorders
… diet (KD) on adipose tissue (AT) metabolism and renin-angiotensin system (RAS) function and potential implications for other tissues, including lung, heart and skeletal muscle. In the first study, it was demonstrated that despite increasing fat mass, a KD enhanced energy-dissipating mechanisms in …
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The Effect of 1,25-Dihydroxy Vitamin D3 on AT1 Cell Receptor Expression in Human Iliac Artery Endothelial Cells (HIAEC)
<p>The renin-angiotensin system (RAS) plays an important part in homeostasis through angiotensin IPs role as a vasoconstrictor. Defects in the renin angiotensin system can lead to hypertension, heart attack, and stroke (Weir, 1999). Studies have shown an inverse relationship between Vitamin D3 and …
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Η σημασία των αγγειακών αλλοιώσεων του νεφρού για την υπέρταση των αρρώστων με ετερόπλευρη χρόνια πυελονεφρίτιδα: Κλινικοπαθολογική μελέτη
… relationship between BP level, scar process and Renin-Angiotensin system. Vascular changes were greater in scarred than in the nonscarred areas, particularly in hypertensive patients. Severe vascular changes in scars were seen only in cases with hypertension. PRA was negatively correlated with …
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The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also …
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