Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"renal fibrosis"”.
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Targeting epithelial senescence to augment renal repair
Effective renal repair following injury is essential for maintaining normal kidney function and is vital to the health of millions of patients every year. Maladaptive repair occurs when kidneys fail to return to normal levels of function following an injury and have excessive fibrosis and resulting …
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Valutazione dell'attività delle metalloproteinasi 2 e 9 nelle urine e nel tessuto renale di cani normali e affetti da nefropatia
… data suggest a role for MMPs in a number of renal pathophysiologies, associated with an imbalance of ECM syntesis and degradation, which may result in an accumulation of ECM molecules and renal fibrosis. The aim of this study is to elucidate the role of pro and activated MMP-2 and 9 in urine …
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Signal Transduction Mechanisms Mediating the Regulation of Vascular G Protein-Coupled Receptors
… increases in the shGRK2 mice, the expression of renal renin angiotensin system (RAS) components increases correspondingly and this has a strong impact on the regulation of both peripheral vascular resistance and sodium balance. The chronic activation of RAS also potentiates renal injury by …
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Design and Synthesis of Orally Bioavailable Sphingosine Kinase 2 Selective Inhibitors
… sickle cell disease, multiple sclerosis, and renal fibrosis. Formation of S1P is facilitated from the ATP dependent phosphorylation of sphingosine (Sph) through its generative enzyme's sphingosine kinase 1 and 2 (SphK1 and SphK2). Inhibition of SphK1 and SphK2 results in the manipulation of …
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Investigating Feeding Omega-3 Polyunsaturated Fatty Acids and/or Soy Protein Isolate to Female pck Rats on Polycystic Kidney Disease and Related Complications
… cyst growth increases kidney volume, decreases renal function, and may eventually lead to end stage renal disease. In addition to renal manifestations, PKD patients are at risk of complications that include bone loss and polycystic liver disease (PLD). Currently, no genetic therapy or effective …
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The Dendritic Cell Response to Exogenous and Endogenous Danger Signals
… may contribute to IL-10 dysregulation in SLE. Renal disease remains a major cause of morbidity and mortality in SLE. A number of mouse models of chronic kidney disease have implicated the EGFR-family receptors in the progression of renal fibrosis and dysfunction. In chapter five we show that …
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Exploring the impact of maternal obesity on offspring renal morphology and later life health
… exposed to maternal obesity. Alterations in renal morphology in early life have been linked to hypertension and renal disease in adulthood in both epidemiological and animal studies. Therefore, a second aim of this thesis was to assess blood pressure, renal function and markers of renal …
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Ο ρόλος του SMAD σηματοδοτικού μονοπατιού στις σπειραματονεφρίτιδες του ανθρώπου
Οι σπειραματονεφρίτιδες (ΣΝ) αποτελούν μια ομάδα νοσημάτων του σπειράματος ανοσολογικής αιτιολογίας που σε πολλές περιπτώσεις οδηγούν στην πλήρη καταστροφή του νεφρικού παρεγχύματος με αποτέλεσμα τη νεφρική ίνωση και την ανάγκη υποκατάστασης της νεφρικής λειτουργίας με μεθόδους εξωνεφικής κάθαρσης. …
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Improving Potency and Oral Bioavailability of Spinster Homolog 2 (Spns2) Inhibitor: A Structure-Activity Relationship Study
In healthy individuals, the autoimmune system is the body's natural defense against foreign materials and organisms. The main tools utilized for this defense mechanism are immune cells. However, in patients suffering from autoimmune diseases, the autoimmune system is overactive resulting in its …
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Der Einfluss von Mycophenolat-Mofetil (MMF) auf die renale Fibrogenese: Bedeutung für neue therapeutische Ansätze
… wurden einerseits ein in-vitro-Modell für renale Fibroblasten (COS-7-Zellen) und andererseits COL4A3-defiziente Mäuse als Tiermodell für eine progrediente renale Fibrose verwendet. Die in-vitro-Experimente bestätigten die inhibitorische Wirkung von MPA sowohl auf die Proliferation von …
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HGF als anti-fibrotisches Agens: Effekte der Überexpression in renalen Fibroblasten und Tubulusepithelzellen
… es zur progressiven Fibrosierung und folglich zu renalem Funktionsverlust. Entscheidend für die Fibrogenese ist die Imbalance zwischen profibrogenen und antifibrogenen Zytokinen. Chronische Schädigungen führen zu einer gesteigerten Expression von TGF-β1, dem potentesten profibrogen wirkenden …
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Die Bedeutung des Kollagenrezeptors α2β1- Integrin bei der Pathogenese und Prävention der Nierenfibrose in hereditären Typ IV- Kollagen- Erkrankungen
… beteiligt. Aufgrund seiner weit reichenden renalen Expression führen Abweichungen seiner Molekularstruktur regelhaft zur Nierenbeteiligung. In hereditären Erkrankungen wie dem Alport- Syndrom, dem Goodpasture- Syndrom und der diabetischen Nephropathie mündet die durch Kollagen- IV- …