Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"renal cysts"”.
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The structural and functional characterisation of the PLAT domain of polycystin-1
… by the progressive development and expansion of renal cysts, which eventually replace the normal architecture of the kidney and lead to kidney failure. (Harris 1999) ADPKD is a common cause of end-stage renal failure. It accounts for 5-8% of patients in haemodialysis units worldwide. It also has …
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An investigation of the Ciliary Protein PKHD1 in Cyst development in liver disease: clues to the pathogenesis of Biliary Atresia
… in a subset of biliary atresia patients with renal cysts, promoting further investigation to determine the functional role of fibrocystin in epithelial cells from renal and biliary tubules. Immunohistochemical studies, using a monoclonal antibody raised against wildtype fibrocystin, showed …
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Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes
… cancer in neurological tissues, the kidneys, adrenal glands, pancreas, and liver, including neurological hemangioblastoma (HB), pheochromocytoma (PCC), pancreatic neuroendocrine tumors (PNET), pancreatic and renal cysts, and clear cell renal cell carcinoma (ccRCC). The disease process follows …
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The role of sphingolipids in autosomal dominant polycystic kidney disease (ADPKD)
… disorder characterized by the development of renal cysts and eventual renal failure. There is currently no cure for ADPKD, but various treatments are available to alleviate the symptoms. In ADPKD, cystic renal epithelia are prevalent by the upregulation of various growth regulating signalling …
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Identifizierung und Charakterisierung von Pkhd1, dem Maus-Ortholog des humanen ARPKD-Gens, sowie Erstellung und Analyse einer Pkhdl mutierten Maus
… disease (ARPKD) is an inherited disorder causing renal-related and liver-related morbidity and mortality in childhood, characterized by renal cysts, biliary dysgenesis and congenital hepatic fibrosis due to ductal plate malformation. With an estimated incidence of 1 in 20,000 up to 50% of the …
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Klonierung und molekulare Charakterisierung von Deletionsbruchpunkten bei juveniler Nephronophthise Typ 1
Die juvenile Nephronophthise (NPH), eine autosomal rezessive, cystische Nierenerkrankung, gilt als häufigste genetische Ursache des terminalen Nierenversagens im Kindesalter. In Vorarbeiten war das Gen NPHP1 für Nephronophthise Typ 1 auf Chromosom 2q13 identifiziert worden, welches sich zwischen …
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Die komplizierte Nierenzyste
… Bei der Beurteilung von zystisch konfigurierten renalen Raumforderungen stellt die Differenzierung zwischen einer benignen Läsionen und einem soliden Nierenzellkarzinomen (RCC) immer noch ein erhebliches klinisches Problem dar. Trotz des Gebrauchs hoch entwickelter Untersuchungsgeräte wie CT und …