Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"renal clearance"”.
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Pharmacokinetics and renal clearance of morphine and its two major metabolites, morphine-3-glucuronide and morphine-6-glucuronide in the rabbit
The pharmacokinetics of morphine and renal clearance of morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G) and morphine (M) were studied following intravenous (IV) administration of single doses of morphine (1.5 mg/kg) alone, in the presence of cimetidine as a loading dose (10 mg/kg) and …
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Die Einmaldosierung von Aminoglykosiden bei unterschiedlicher Nierenfunktion in der Intensivmedizin
… empirically result in changes to the renal clearance on the one hand. On the other hand the aim of the test is to ascertain whether the recommended therapeutic levels are reached or even exceeded. This study is a retrospective analysis of the data of 47 patients taken from a collective …
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Monitoring of occupational exposure to antineoplastic drugs
… To fully validate the biomarker CP in urine, renal clearance of CP was investigated at low plasma and urine concentrations relevant for occupational exposure to CP. This was performed by studying patients treated with CP up to 12 days after the dose. There was no dependence between the plasma …
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Μελέτη της σωληναριακής μεταφοράς του ουρικού οξέος στην πολυκυστική νόσο των ενηλίκων με τη χρήση των δοκιμασιών πυραζιναμίδης και προβενεκίδης
… norepinephrine, PTH, drugs, e.t.c.). In chronic renal failure (CRF) irrelevant of primary kidney disease, recent studies have shown that the quantity of the urate excreted per nephron is increased, mainly by a supression of postsecretory reabsorption, and also by supression of presecretory …
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Uric acid metabolism in the Dalmatian coach hound
… hyperuricaemia, hyperuricosuria and increased renal uric acid clearance. These properties are associated with hypoallantoinaemia and hypoallantoinuria. A result of these abnormalities is a high incidence of urate urolithiasis in this breed. Other diseases such as recurrent dermatitis, chronic …
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Surface Modifications of Iron Oxide Nanoparticles for Magnetic Imaging and Diagnosis
… agents, with unprecedentedly fast and clean renal clearance in inorganic colloidal nanoparticles. An approach for size determination based on small-angle X-ray scattering (SAXS) was developed, and understanding of particle size distribution led to successful development of …
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Quantitative evaluation of image quality in CT imaging using iodine and nanoparticle-based contrast agents
… used, they are limited by toxicity, rapid renal clearance, and risk of allergic reactions. Subsequently research has increasingly focused on high atomic number nanoparticles, such as bismuth and tantalum, which offer strong X- ray attenuation with reduced toxicity, making them promising …
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Studies on the Pharmacokinetics of Pinacidil in Healthy Volunteers
… of pinacidil in healthy volunteers were; Clearance = 32.3 ± 10.3L/h; Apparent Volume of Distribution = 102.9 ± 16.6 L. The serum elimination half-life of pinacidil was 2.4 ± 0.7h. Pinacidil was found to be cleared from the body primarily by hepatic clearance and to have a low to medium …
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Gut Microbiome Dysbiosis Exacerbates Malaria Severity in Ugandan Children
… levels during SM from hemolysis and impaired renal clearance likely increases levels of intestinal uric acid, which supports the growth of uricase producing bacteria such as Enterobacteriaceae. Furthermore, Enterobacteriaceae associated with multiple complications of SM such as coma, severe …
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Syntheses of biocompatible luminescent nanocrystals for visible and short-wave infrared imaging applications
… that is small enough that they exhibit a rapid renal clearance, and images taken in the SWIR region show better resolution of the blood vessels than in the NIR region.
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Mining Genomic Variants And Causal Pathways Linking Hdl And Triglycerides To Coronary Disease
… and animal models suggest that A43T accelerates renal clearance of circulating ApoC-III, thus hindering its function in delaying TG-rich lipoprotein turnover. These data establish ApoC-III clearance mechanisms as potential therapeutic targets for TG lowering. Finally, we adapted a targeted …
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The effect of Retinol Binding Protein on the Proteome of muscle cells.
… small molecules have been designed to promote renal clearance of RBP, thus lowering serum levels. In order to consolidate the theories surrounding RBP induced insulin resistance, a proteomic study was devised to determine the direct effect of RBP on muscle cells, since the muscle is the main …
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Design and synthesis of biocompatible fluorescent semi-conductor nanocrystals for in-vivo and in-vitro imaging/sensing applications
… first time collection of quantitative in-vivo renal clearance data of inorganic nanoparticles in a mouse as a model for design of future clearable nanoparticle in-vivo probes and drug delivery vehicles. On the in-vitro front, a suite of multifunctional ligands were synthesized to produce QDs …
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The Pharmacokinetics of Firocoxib after Multiple Oral Doses to Neonatal Foals
… drugs, (NSAIDs), particularly due to immature renal clearance mechanisms and ulcerogenic effects on gastric mucosa. Firocoxib, a novel second generation NSAID, is reported to have reduced side effects due to its COX-2 selectivity. The pharmacokinetic profile of firocoxib in neonates has not …
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Plutonium pharmacokinetics and blood biochemistry
… plutonium is bound avidly in liver and bone; clearance half-lives from these organs differ (by a factor of 2.5) but are very long - a minimum of 50 years for bone; this is why plutonium urinary excretion levels are very low. Despite all the research work that has been carried out there are …
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Effects of feeding lasalocid and monensin upon mineral status of steers, and partial absorption and renal handling of minerals in sheep
… status of ruminants, changes in digestive and renal physiology which bring about altered mineral status, and the effects of dietary K upon the actions of ionophores. Two 84-d grazing trials were conducted with steers fed no ionophore, 200 mg lasalocid, or 150 mg monensin. Monensin tended to …
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THE EFFECTS OF VITAMIN-C ON THE PHARMACOKINETICS OF CAFFEINE IN ELDERLY MALES
… apparent volume of distribution (V), total body clearance (TBC), renal clearance (RC), and metabolic clearance (MC) of caffeine were determined. Simultaneous plasma (PVC), whole blood (WBVC), and leukocyte (WBCVC) vitamin C concentrations were obtained. All of the mean vitamin C values determined …
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DESIGN AND DEVELOPMENT OF RNA-BASED DRUGS USING MOLECULAR DYNAMICS SIMULATIONS AND ARTIFICIAL INTELLIGENCE METHODS
… degradation, high net negative charge, and rapid renal clearance. To address these challenges, advanced chemical modifications, such as Xeno Nucleic Acids (XNAs) and 2-OH modifications, along with specialized delivery systems, including viral vectors and lipid nanoparticles (LNPs), have been …
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Targeted Imaging Agents for Detecting Tumour Cell Death following Therapy
… biodistribution profile, with predominantly renal clearance and minimal retention in spleen (0.79±0.05 %ID/g), liver (1.18±0.13 %ID/g), small intestine (0.97±0.25 %ID/g) and kidney (6.90±0.56 %ID/g) at 2 h after probe administration. In a xenograft model of colorectal cancer treated with a …
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Bevacizumab Effect on Topotecan Pharmacokinetics in a Murine Orthotopic Rhabdomyosarcoma Xenograft Model
… with the increased systemic elimination rate and clearance of TPT. Furthermore, a single dose BEV had a time-dependent effect on the tumor elimination rate of TPT. The elimination rate of TPT from tumor compartment increased when it was given 1 day after a single dose of BEV and gradually …
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