Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"renal cell carcinoma"”.
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. Neuroblastoma is an embryonal tumor …
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Molecular genetic investigations of renal cell carcinoma predisposition
Renal Cell Carcinomas (RCC) are a diverse group of histologically and genetically distinct renal neoplasms accounting for 2.4% of all cancers worldwide. While a majority of RCC cases are sporadic in nature, a proportion are due to genetic predisposition caused by syndromic and non-syndromic …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer, is characterised by biallelic inactivation of the von Hippel-Lindau (*VHL*) tumour suppressor gene, and inherited loss-of-heterozygosity of *VHL* underlies the eponymous hereditary cancer syndrome. The *VHL* protein …
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SMARCB1 Maintains Lineage Fidelity in Clear Cell Renal Cell Carcinoma
… types remain poorly understood. Using clear cell renal cell carcinoma (ccRCC) as a model, I characterise mechanisms that underlie lineage factor dependence in cancer. Using CRISPR/Cas9 loss-of-function screening coupled with in vitro and in vivo validation I show that the loss of SMARCB1, a …
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Investigations into the mechanism of genomic instability in renal cell carcinoma
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Trend and Impact of Nephrectomy Centralisation on Renal Cell Carcinoma Survival
Introduction The incidence of renal cell carcinoma is increasing worldwide. The widespread use of radiological imaging has contributed to disease stage migration with greater proportion of small, asymptomatic renal tumours often detected incidentally. Despite this, mortality from RCC has not …
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Investigating the Role of Hippo/Warts Signaling in Sarcomatoid Renal Cell Carcinoma
Renal cell carcinomas (RCCs) are the most common kidney malignancy and one of the most common cancers overall. Sarcomatoid RCC (sRCC) is a particularly aggressive subtype of RCC which displays a high rate of metastasis and poor prognosis, contributing to a disproportionately high clinical burden. …
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A Study Of The Molecular Genetics Of Renal Cell Carcinoma In Man
… isoforms 165 and 189 mRNA in patients with renal cell carcinoma (RCC). Patients with RCC underwent radical nephrectomy at Derriford Hospital, Plymouth. Tumour as well as matched normal tissue from the kidney was harvested, snap frozen and stored in liquid nitrogen, and used to quantitate …
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Prognostic Significance of Chromosome 9p Deletion in Clear Cell Renal Cell Carcinoma
… role of chromosomal copy number aberration in renal cell carcinoma (RCC) has been explored in several studies. Chromosome 9p deletion was reported as an independent prognostic factor in clear cell subtype (ccRCC). The findings from these studies initially appeared promising however they were of …
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Apoptosis and Necroptosis in Renal Cell Carcinoma // Апоптоза и некроптоза при бъбречноклетъчен карцином
… years. Currently, known standard approaches for renal cell carcinoma treatment are insufficient in some cases due to resistance to chemo- and radiotherapy. Pathway activation of one or another form of cell death can be used in the search for new approaches in renal cell carcinoma treatment. There …
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The role of stem cells and WNT signalling pathway in renal cell carcinoma
Introduction: Renal cell carcinoma (RCC) accounts for 87% of all kidney cancers. Despite advances in diagnostic techniques and management, renal cell carcinoma remains a lethal tumour accounting for substantial mortality and morbidity. The poor prognosis arises from metastasis, chemoradiation …
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Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma
… implicated in the regulation of intracellular signaling pathways. Altered caveolin-1 expression is thought to be involved in several important human diseases including cancer. However, the role of caveolin-1 in renal cell carcinoma (RCC) is still uncertain. Some reports have suggested …
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Endogenous Reporter Systems for High-Throughput Functional Screening in Clear Cell Renal Cell Carcinoma
… development of therapeutic approaches. In clear cell renal cell carcinoma (ccRCC), loss of von Hippel-Lindau tumour suppressor (VHL), seen in 90% of ccRCCs, leads to the stabilization of hypoxia inducible factor HIF2A and aberrant expression of its downstream targets such as the chemokine …
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Prognostic and Predictive Factors in Renal Cell Carcinoma /// Прогностични и предиктивни фактори при бъбречноклетъчен карцином
В изследването са включени 148 пациента с бъбречноклетъчен карцином разделени в две групи: 98 без метастази и 50 с метастази. Направен е сравнителен анализ на двете групи по отношение на големина на тумора, степен на диференциация, туморна некроза, саркоматоидна компонента и ангажиране на бъбречна …
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A multifaceted study of the receptor tyrosine kinase Axl with focus on Renal Cell Carcinoma
… in several human malignancies, with focus on renal cell carcinoma (RCC). At first, our main interest concerned the intracellular Axl interactor named Tensin2 (Tns2) and its family member Tensin3 (Tns3). Tns2 and Tns3 are structural focal adhesion proteins, linking the extracellular matrix and …
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Investigating the role of SWI/SNF chromatin remodelling complex in Clear Cell Renal Cell Carcinoma
… PBRM1 is mutated in approximately 40% of clear cell type renal cell carcinoma (ccRCC). In this study, we characterised the composition of SWI/SNF complexes in ccRCC cells finding that the PBRM1 and SMARCC1 subunits are frequently depleted in ccRCC cell lines. Furthermore, using a ccRCC specific …
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Small Molecule Inhibitors of MAPK and PI3K Pathways Enhance MDA-7 Lethality in Renal Cell Carcinoma
Renal cell carcinoma accounted for an estimated 57,760 new cases and estimated 12,980 deaths in the United States in 2009. Current treatment options for systemic renal cell carcinoma yield markedly low response percentages; however, recent cytokine therapy experiments have produced promising …
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Modulating Immunometabolism to Improve The Activity of Car-Nk Cells Targeting Cd70 In Renal Cell Carcinoma
… of several therapies for metastatic clear cell renal cell carcinoma (ccRCC), disease resistance and relapse are common, and therapies with novel mechanisms of action are urgently needed. Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable responses in hematologic …
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Autologous Proliferative and Immunobiological Modelling of Patient-Derived Clear Cell Renal Cell Carcinoma and Kidney Organoids
… as the new standard of care for advanced clear cell Renal Cell Carcinoma (ccRCC), the deadliest urological malignancy. However, both efficacy and toxicity of immunotherapies is highly patient-specific and difficult to predict. This underscores the need for robust preclinical models of …
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Novel multi-parametric, multi-modality imaging for the assessment of tumour biology in renal cell carcinoma
Renal cancer (RCC) is the 7th commonest cancer in the UK and clinically, morphologically, genetically and metabolically heterogeneous. Inaccurate patient stratification limits the treatment of RCC. This thesis investigates imaging techniques and image-analysis methods ranging from easily …
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