Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"remyelination"”.
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
Remyelination is the generation of new myelin sheaths after injury, and is accomplished by oligodendrocyte precursor cells (OPCs) that proliferate, migrate, and differentiate into myelin-forming oligodendrocytes. A number of lesion-associated factors have been identified that interfere with the …
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CNS Remyelination and the Gut Microbiota
Remyelination describes the regeneration of myelin sheaths, and is considered one of the most promising strategies for improving the prognosis of demyelinating diseases such as multiple sclerosis. Data from animal models and human studies have shown that remyelination can occur extensively in the …
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Visual Outcome Measures of Remyelination and Neuroprotection in Multiple Sclerosis
… therapies capable of enhancing endogenous remyelination. Recent trials of remyelination-promoting drugs have marked the beginning of a new phase in the development of treatments capable of repairing MS damage (Green et al., 2017, Cadavid et al., 2019, Cadavid et al., 2017, Brown et al., …
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Stab Wounds to Rat Brains : Demyelination, Remyelination and the Cellular Response, Particularly of Oligodendrocytes
… stages of demyelination, and the evidence for remyelination are of interest. Following stab wounds to rat brain cortex, corpus callosum and hippocampus, the animals were examined at 4,7,11,18,23,29,45,60 and 70 days postoperation (dpo). To help in the identification of cells immunocytochemical …
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Promoting and measuring remyelination and neuroprotection in clinical trials of people with multiple sclerosis
… progressive phase of MS is to promote endogenous remyelination; doing so restores nerve conduction and prevents demyelinated axons from degenerating. The rate-limiting stage in this process is differentiation of oligodendrocyte progenitor cells (OPCs) into mature, myelinating, oligodendrocytes. In …
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
Remyelination is a regenerative process that occurs through the formation of myelin sheaths by oligodendrocytes, which are recruited as oligodendrocyte progenitor cells (OPCs) after demyelination in diseases such as Multiple Sclerosis (MS).A key environmental factor regulating OPC differentiation …
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LIPID COMPOSITION OF MICROGLIAL CELLS AND EFFECTS OF A REMYELINATION-PROMOTING ANTIBODY ON THE SPHINGOLIPID PATTERNS
Multiple sclerosis (MS) is one of the most prevalent demyelinating diseases among young adults (Lemus et al., 2018). Myelin damage and oligodendrocyte death are caused by the autoimmune attack of T cells that cross the blood-brain barrier resulting in the formation of sclerotic plaques (Pearce, …
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Towards a blood-based biomarker for remyelination: Glial cell death and associated byproducts in demyelinating disease
… and non-invasively assessing changes in remyelination status remain limited. Recent studies have found that cell-free DNA (cfDNA) released from dying neurons and glia can be detected in the bloodstream using cell-specific methylation patterns. A better understanding of …
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Investigating the role of cellular communication network factor 3 (CCN3) in central nervous system myelination and remyelination
… uncovering the mechanisms that regulate remyelination is an essential task to elucidate druggable targets and improve the quality of life of people living with MS or other demyelinating conditions.<br/><br/>Previously, we reported that regulatory T cells (Treg) are required for efficient …
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Imaging Myelin Basic Protein expression in a model of remyelination by Magnetic Resonance Imaging using an Organic Anion Transporter Protein gene reporter system.
… a clinical need for therapies that enhance remyelination. This can be achieved by 1) pharmacologically targeting endogenous oligodendrocyte progenitor cells (OPCs) responsible for remyelination or 2) transplantation of myelinogenic cells (including OPCs). The first approach is appropriate …
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DISEASE-MODIFYING APPROACHES TO MULTIPLE SCLEROSIS: DESIGN AND SYNTHESIS OF NOVEL POTENTIAL THERAPEUTIC AGENTS
… but in the context of the lesion the remyelination process fails, eventually causing axonal degeneration. In my PhD project, these challenges were addressed by facing them separately and by applying different strategies. 1. Inhibition of Neuroinflammation through astrocyte manipulation …
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Morphological and Physiological Examination of a Demyelinating and Remyelinating Lesion
… of the disease. The repair of the fibers by remyelination has been advanced as a potential symptomatic therapy, but at present the conduction properties of remyelinated central fibers are not well understood. In this study the conduction properties of Schwannian or oligodendrocyte …
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Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System
… CNS. The onset and timing of CNS myelination and remyelination requires precise coordination between epigenetic programming and transcriptional regulation. In this thesis, I present my findings on two epigenetic regulatory complexes Chd7/Sox10 and lncOL1/Suz12 in CNS myelination and remyelination. …
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Exploring the methylome and transcriptome of young adult and aged OPCs
Remyelination is the restoration of myelin sheaths to denuded axons following demyelinating events, which occurs spontaneously in adult mammals, including humans. The principal cells which participate in remyelination are the Oligodendrocyte Progenitor Cells (OPCs). Similar to other regenerative …
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Regulation of oligodendrocyte lineage cell function by the RXR$\gamma$ nuclear receptor
Remyelination is a spontaneous regenerative process whereby myelin sheaths are restored to demyelinated axons. Key players in this process are oligodendrocyte progenitor cells (OPCs), a widespread population of CNS progenitor cells which persist into adulthood. Remyelination is impaired in patients …
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Investigating the role of microglial senescence in central nervous system injury and regeneration
… signal transmission. Although microglia promote remyelination following demyelination, they can become dysfunctional with ageing and neurodegenerative disease in association with impaired remyelination. The mechanisms underpinning this dysfunction are unclear. One of the hallmarks of ageing is …
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The effect of aging on myelinating gene expression and oligodendrocyte cell densities
… repair by oligodendrocytes (OLs). To study CNS remyelination during aging, I used the cuprizone (a copper chelator) mouse model. Inclusion of cuprizone in the diet kills mature OLs and demyelinates axons in the rostral corpus callosum (RCC) of mice, which enabled me to characterize age-related …
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Evaluation of the PI3K/Akt/mTOR pathway in Multiple Sclerosis
… pathway may be useful to promote the remyelination process, so to reverse disability in MS patients. Then, the data generated in silico were subjected to an ex-vivo evaluation. To this aims the involvement of mTOR was validated on a well-known animal model of MS and in vitro on Th17 …
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Investigating interplay between human regulatory T cells and oligodendrocyte lineage cells
… generate new myelin sheaths, a process termed remyelination. The signals that influence this process in the central nervous system (CNS) of MS patients are still not fully understood, however, recent studies have uncovered an important role for the immune system in promoting remyelination in …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
… nervous system (PNS), can contribute to CNS remyelination. Although CNS-resident SCs were previously thought to have migrated into the CNS from peripheral sources, lineage tracing studies demonstrated that adult CNS progenitors, oligodendrocyte progenitor cells (OPCs), can produce SCs in …
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