Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"relaxin"”.
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BEHAVIOURAL ANALYSIS OF ZEBRAFISH RELAXIN-3A MUTANT
The insulin-related neuropeptide relaxin-3 (RLN3) has been implicated in stress responses, feeding and anxiety. Most studies have focused on the peptide encoded by the A- and B-chains, and have been conducted using rodents. This thesis explores the <i>rln3a</i> gene in zebrafish, to test whether …
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The use of monoclonal antibodies specific for rat relaxin to study the physiological roles of relaxin in pregnant rats
… determine the physiological roles of endogenous relaxin in pregnant rats by passive immunization with a monoclonal antibody specific for rat relaxin (MCA1). Recently, Lao Guico-Lamm and Sherwood demonstrated that rats treated with MCA1 throughout the second half of pregnancy exhibited prolonged …
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The Effects of Relaxin on The Composition of Bovine Milk
… into the mysteries of one such hormone, relaxin.</p>
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Some Observations Pertaining to the Effects of Relaxin Upon the Bovine
… is facilitated in some rodents by the action of relaxin upon the symphysis pubis and pelvic bones. Relaxin is a female hormone secreted by the placenta, uterus and ovaries and is present in the blood during gestation of many animals. Relaxin apparently has two purposes in the human uterine …
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Identification of Relaxin-Target Tissues and Target Cells in the Pig
We conclude that the specific relaxin-binding cells probably contain relaxin receptors and, may therefore mediate relaxin's effects in its target tissues of pigs.
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Effects of relaxin on the electrophysiological properties of isolated atrial myocytes
ETDs are only available to UIUC Users without author permission
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Monoclonal Antibodies Specific for Rat Relaxin: Production, Characterization and Use to Neutralize the Biological Actions of Endogenous Relaxin Throughout the Second Half of Pregnancy in the Rat
The role of relaxin during pregnancy and at parturition in the rat is not absolutely established. There are limitations to the experimental approach used in the few studies that examined the influence of relaxin in the pregnant rat. These studies were unphysiological since they involved exogenous …
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Evidence That Endogenous Relaxin Promotes Vaginal Growth and Softening in Pregnant Rats
Rat relaxin is produced and secreted by the ovary throughout the second half of pregnancy. Relaxin promotes growth and softening of the cervix to enable rapid and safe delivery. When this studies were initiated there was no evidence that endogenous relaxin has effects on the vagina, which is linked …
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The role of relaxin in the regulation of human liver and kidney fibrosis
… that disrupt liver architecture and function. Relaxin<br/>is a hormone involved in remodelling of extracellular matrix in the uterus and<br/>cervix and is known to increase renal blood flow in pregnancy. It has been<br/>implicated in the regulation of fibrosis in animal models and to modify the …
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Relaxin: a new cardiovascular hormone in humans? Comparative potency and mechanisms of action
… The focus of this MD thesis has been relaxin, a member of the insulin family, which is a protein composed of two disulphide linked chains of approximately 6000 Daltons. Relaxin has been traditionally recognised as a hormone of parturition, though more recently it has been postulated …
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The mammary nipples are vital endocrine target tissues for relaxin in the rat
Restriction data tranferred 2014-07-01T11:31:36-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission
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The physiological role of relaxin in the pregnant gilt: The effects of relaxin on the physical and biochemical properties of the cervix and on mammary development in ovariectomized hormone-treated pregnant gilts
… was to determine the physiological roles of relaxin in pregnant gilts by ovariectomizing gilts during the last third of gestation followed by hormone replacement therapy. Nara and coworkers demonstrated that in pigs ovariectomized in late pregnancy a prolonged delivery and a low incidence of …
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Relaxin: Target Tissues and Effects on Uterine Contraction in Vivo and in Vitro in the Rat
Possible target tissues for relaxin in estrogen-primed ovariectomized rats were identified by determing (1) the tissue distribution of injected ('125)I-labeled relaxin (('125)I-relaxin) in vivo and (2) the changes in cyclic AMP (cAMP) levels in several tissues following incubation with relaxin in …
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Evidence That Relaxin Promotes Cellular Proliferation in the Lower Reproductive Tract of the Pregnant Rat
… this is the first study to determined that relaxin promotes growth of the vagina during pregnancy in any species. Furthermore, this study also determined that the relaxin-induced growth of the cervix is brought about, in part, by promoting the cellular proliferation of cervical epithelial …
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Regulation of Serum and Ovarian Relaxin Levels and Corpus Luteum Function During the Second Half of Pregnancy in the Rat (Ovary, Birth, Gestation)
… were conducted to investigate the regulation of relaxin synthesis and secretion by the ovary from days 12 to 20 of pregnancy in the rat (Phase I). Initial immunocytochemical studies utilizing a specific rabbit anti-rat relaxin serum demonstrated that the cells of the corpus luteum (CL) are the …
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Expression of recombinant porcine preprorelaxin in Nicotiana tabacum
Relaxin is a small peptide hormone that has demonstrated potential therapeutic actions for cardiovascular disease and fibrosis. Additionally, relaxin has demonstrated the ability to protect the heart from injuries caused by ischemia and reperfusion, promote the healing of ischemic ulcers, and …
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The Roles of Relaxin, Estrogen and Progesterone on Growth and Remodeling of the Cervix and Mammary Glands in the Gilt
We recently described relaxin-induced changes in physical and biochemical properties of the cervix that occur during the last third of the 115-day gestation period in the gilt. Histological changes in the cervix that occur between days 80 and 110 of pregnancy and the effects of relaxin on those …
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Influence of Blocking the Actions of Relaxin, Estrogen and Progesterone on the Rates of Proliferation and Apoptosis of Cervical Cells During Rat Pregnancy
… described in this thesis provide evidence that relaxin, estrogen and progesterone contribute to the increase in the cervical cell content during the second half of pregnancy by promoting proliferation and inhibiting apoptosis of cervical cells. The extent to which relaxin affects these cellular …
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Regulation of Antepartum Relaxin Release in the Pregnant Rat: Role of the Maternal Pituitary Gland, Luteinizing Hormone and Prostaglandins
… of the antepartum elevation and decline of serum relaxin levels in the pregnant rat is poorly understood, but may be related to functional luteolysis (Endocrinology 107:671, 1980). Factors which served as a beginning for the investigation of the regulation of antepartum relaxin release were those …
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Improving the delivery and efficacy of molecular medicine via extracellular matrix modulation : insights from intravital microscopy
… bacterial collagenase, or indirectly with relaxin treatment, resulted in increased diffusion coefficients of macromolecules within tumors in vivo. In order to quantitate the changes in collagen content and structure induced by relaxin treatment, we adapted and further developed the imaging …
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