Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"relapse risk"”.
-
Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia
… fluid are related to systemic levels and risk of a central nervous system (CNS) relapse, to build a population pharmacokinetic model from methotrexate concentration time data and assess how pharmacokinetic parameter predict relapse risk. An increase in serum creatinine of more than 50% …
-
Imitation Learning with Superhuman Policy Gradient Optimization for Sequential Cancer Treatment Decisions
… across multiple clinical outcomes, including relapse at year three and patient-reported toxicities at multiple follow- up times. We systematically compare six subdominance configurations (absolute vs. relative, sum vs. max aggregation, per-feature vs. max-only α updates) to assess how loss …
-
Aromatherapy in Substance Withdrawal Treatment Programs in Adults: A Systematic Review [paper]
… with withdrawal symptoms, anxiety, and relapse risk, all resulting in difficulty in ensuring abstinence. Current therapy has proven to be successful, but providers seek to incorporate integrative therapies as adjunctive therapy. This systematic review examines and evaluates the …
-
Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia
… 1) A low ARID5B expression will increase the relapse risk of ALL, 2) Genetic variants of ARID5B will affect its expression and thus influence susceptibility to childhood ALL, 3) IGF2BP1 is transcriptionally suppressed by ETV6, 4) ZNF384-mediated fusion genes transcriptionally upregulate FLT3 …
-
Quantitative assessment of the pharmacotherapy of biopolar disorder and schizophrenia
… The mean follow-up period was 5-34 months. The relapse risk ratio for lithium versus placebo was 0.47 (95% CI 0.26 to 0.86) and the NNT was 3 (95% CI 2 to 7). The relapse risk ratio for lithium versus imipramine was 0.62 (95% CI 0.46 to 0.84) and the NNT was 4 (951% Cl 3 to 7), The combination …
-
SOCIAL PROBLEM-SOLVING, NEGATIVE AFFECT, AND SMOKING URGE REACTIVITY DURING BASELINE CUE EXPOSURE
… the majority of smokers who seek treatment will relapse. To better understand nicotine dependence, and relapse risk factors this study tested for potential relationships between social problem-solving, negative affect, and smoking urges during a baseline smoking cue exposure trial. Methods: aA …
-
Immunotherapy and immunosuppression in myeloid leukemia
… interleukin-2 (IL-2) for the prevention of relapse of AML after the completion of chemotherapy. Paper I reports that the functions and viability of cytotoxic lymphocytes, including NK cells, were compromised by ROS produced by leukemic myeloid cells recovered from patients with CMML. The …
-
Culturally Informed Motivational Interviewing to Improve Oral Chemotherapy Adherence for Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers: A Feasibility, Acceptability, and Preliminary Efficacy Trial
… has been associated with an increase in relapse risk. Accordingly, interventions that enhance 6-MP adherence during ALL maintenance chemotherapy may result in decreased morbidity and mortality for pediatric ALL patients. This study investigated the feasibility and acceptability of brief, …
-
Functional identification of molecular oncotargets associated with the resistance to ALK inhibition in neuroblastoma via genome-wide CRISPR-Cas9 screens
… sequencing studies of hundreds of high-risk neuroblastoma (hNB) patients have identified Anaplastic Lymphoma Kinase (ALK) as the only directly ‘druggable’ target with a significant mutation rate (9%). ALK is a receptor tyrosine kinase whose dysregulation has been implicated as the driver …
-
Factors Predicting Relapse from Substance-related Care and Support Services
Relapse is a common part of the recovery process for individuals with substance use disorders and is often defined as any return to substance use after a period of abstinence. Relapse occurrence interrupts the recovery process and places increased pressure on substance-related care and support …
-
IKAROS and LEUKEMIA
… use of polychemotherapy and implementation of risk stratification based on the presence of certain acquired genetic changes in pediatric B-cell precursor (BCP) ALL have increased the overall survival rates substantially; they are now approaching 90%. This notwithstanding, 20% of patients still …