Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 137 for “"regulatory protein"”.
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On mass spectrometry analysis of gene regulatory protein-DNA interactions
Contains fulltext : 194868.pdf (Publisher’s version ) (Open Access)
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Functional dissection of ParB homologue and global regulatory protein KorB of RK2
… a global regulator and as an active partitioning protein. This study focuses on its role as a global regulatory protein and its interaction with DNA, RNAP and other repressor proteins (e.g KorA and TrbA) of RK2. It is shown for the first time that DNA binding by negatively charged protein KorB …
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Relating metal binding to DNA binding in the nickel regulatory protein NikR
… of low affinity nickel binding sites on the protein. Recently, it has been shown that NikR also requires K+ to bind DNA, suggesting yet another type of metal binding site on the protein. To understand NikR's ability to bind multiple transition metal ions and how Ni2+ specifically induces …
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Klonierung und Charakterisierung von Signal Regulatory Protein beta in primären Makrophagen der Maus
�Signal Regulatory Proteins� (SIRP) sind glykosylierte Transmembran-Proteine, gehören zur Immunglobulin-Superfamilie und werden von zahlreichen Zellen des hämatopoetischen Sys-tems, Nervenzellen und Fibroblasten exprimiert. Sie werden in 2 Gruppen, SIRPa und SIRPb unterteilt. Vertreter der SIRPa …
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Uncovering the Redox Potential of the Global Gene Regulatory Protein DksA in Borrelia burgdorferi
… One critical component is the global gene regulatory protein DksA, which is responsible for reducing the expression of housekeeping genes during the stringent response, while promoting the expression of virulence genes during infection. The mechanistic details of how DksA is able to sense …
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Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)
… and preliminary data suggested that Signal Regulatory Protein-α (SIRPα) also plays a vital part in this protective effect. However, the protective mechanisms by which SIRPα sustains β-cell viability are poorly understood. Recently, it has been proposed that histone deacetylase 6 (HDAC6) …
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The role of signal regulatory protein alpha in regulating macrophage subset activity in homeostasis and inflammation
… of two subsets, pro-inflammatory M1s and regulatory M2s. Both subsets express signal regulatory protein alpha (SIRPα), receptor to CD47. Characterised as a “don’t eat me” signal, SIRPα-CD47 ligation negatively regulates Mφ phagocytic activity. This study developed a co-culture system …
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Phenotypic Analysis of the Regulatory Role of the Leucine-Responsive Regulatory Protein (LrpPA) in Pseudomonas aeruginosa
… new targets for therapy. The leucine- responsive regulatory protein (Lrp) could be a promising target for treatment. The ortholog in <em>Escherichia coli</em> is a global regulator of metabolism and regulates many genes related to amino acid degradation, transport and synthesis. There are …
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Investigation of the Molecular Interaction Between Pyr mRNA and the Bacillus Subtilis Attenuation Regulatory Protein, PyrR
Gel mobility shift experiments using progressively shorter variants of BL2 mRNA determined that the minimal RNA necessary for tight PyrR binding was 28 nt long. The stoichiometry of the PyrR-pyr mRNA interaction was determined to be equimolar using a gel mobility shift titration assay. The effects …
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Changes in Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and Regulatory Protein Content in Congestive Heart Failure
… attributed to altered calcium handling. The main proteins involved in calcium release are the ryanodine receptor (RyR) and the dihydropyridine receptor (DHPR). The main proteins involved in calcium uptake are the fast and slow isoforms of sarco(endo)plasmic reticulum calcium ATPase (SERCA 1 and …
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Molecular Regulation of Mitochondrial Biogenesis in Exercised and Fasted Human Skeletal Muscle: an Examination of Emerging Regulatory Protein
… examining the impact of exercise and fasting on regulatory protein with emerging roles in mitochondrial biogenesis. We first review the literature to critically evaluate the ability of PGC-1alpha to coordinate mitochondrial biogenesis in human muscle and highlight a number of regulatory protein …
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Investigating the role of Leucine-Responsive Regulatory Protein (Lrp) in the production and regulation of specific virulence factors in Pseudomonas aeruginosa
… sensing virulence factors. Leucine-responsive regulatory protein (Lrp) is a known global regulator in <em>E. coli</em> and if proven to be a global regulator in <em>P. aeruginosa</em>, it could be a potential new target in <em>P. aeruginosa</em> infections. The virulence factors pyocyanin, …
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Role of the Leucine-responsive Regulatory Protein during growth of the bacterial corn pathogen Pantoea stewartii subspecies stewartii in the xylem environment
… transcriptional regulator, Leucine-responsive Regulatory Protein (Lrp). To better understand the role of Lrp when Pss inhabits the xylem, RNA-Seq experiments comparing Pss wild-type and ∆lrp strains grown in planta were conducted to ascertain differential gene expression. The RNA-Seq data was …
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Cloning and expression of a functionally active truncated N-glycosylated KSHV complement regulatory protein and immunohistochemical studies with the anti-KCP peptide antibody
… open reading frame (ORF) 4 encodes a complement regulatory protein (Kaposi complement-binding protein, KCP) that binds complement proteins and inhibits the complement-mediated lysis of cells infected by the virus, thus providing a strategy for evasion of the host complement system. Kaposi's …
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A Molecular Genetic Investigation of the Regulation of Outer Surface Protein C in Borrelia Burgdorferi: Identification and Characterization of the Novel Regulatory Protein BBD18
… and subsequently alter their gene expression and protein profiles. As part of this adaptation, spirochetes within the tick midgut downregulate outer surface protein (Osp) A and upregulate OspC. Although OspC is an essential B. burgdorferi virulence factor needed for early mammalian infection, it …
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A Molecular Genetic Investigation of the Regulation of Outer Surface Protein C in Borrelia Burgdorferi: Identification and Characterization of the Novel Regulatory Protein BBD18
… and subsequently alter their gene expression and protein profiles. As part of this adaptation, spirochetes within the tick midgut downregulate outer surface protein (Osp) A and upregulate OspC. Although OspC is an essential B. burgdorferi virulence factor needed for early mammalian infection, it …
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In vivo study of the expression of the genes serA and gltD regulated by Lrp (Leucine-responsive regulatory protein) in Escherichia coli K-12
The plasmid pBAD22 lrp $\rm Cm\sp{R}$ carrying the lrp coding region immediately downstream from the $\rm p\sb{BAD}$ promoter was used to vary intracellular concentrations of Lrp. The expression of the genes serA and gltD was determined in the presence of different concentrations of Lrp. The …
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Transcriptional Regulation of the Bacillus Subtilis pyrG Gene Encoding Cytidine Triphosphate Synthetase
I propose that a trans-acting regulatory protein binds to the pyrG GGGC and GCUCCC sequences when intracellular CTP levels are low, which prevents the formation of the terminator and permits transcription readthrough. When intracellular CTP levels are high, I propose the regulatory protein …
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